Clinical Trials for Toxoplasmosis
Clinical trials are research studies conducted in an effort to improve overall patient health and care.
Each trial involves running supervised tests to determine the effectiveness and safety of new drugs, procedures and/or devices with the aim of answering scientific questions about a disease or condition.
Risks and side-effects are also evaluated during these trials with results ranging from being unpleasant, with side effects such as headaches, to more serious or even life-threatening risks.
A clinical trial may be separated into phases, or steps, with each step designed to answer a separate research question. This maybe reflected in the trial name.
A brief description of each phase:
- Phase I: Usually designed to evaluate safety, determine a safe dosage range, and identify side effects on a small group of patients.
- Phase II: If Phase I is successful, the trial is then repeated with a larger group to further evaluate its effect and safety.
- Phase III: Trials are conducted on an ever larger group and are compared with the best current treatment while gathering more information on effect and safety.
- Phase IV: These studies monitor long-term side effects after the treatment has been marketed.
Clinical Trials data for Toxoplasmosis is grouped into the following categories:-
The format for each of the following is:
- The name of the trial,
- followed by whether the trial is recruiting patients,
- The trial may not have started and not yet recruiting, or the trial may have started and do not need any more recruitements, or the trial may be completed.
- Note**: Please follow the link to determine the current trial status.
- followed by a list of drug/s, if any, used in the trial
ClinicalTrials.gov has listed the following trials for Toxoplasmosis:
- Primary Prophylaxis of Cerebral Toxoplasmosis in HIV-Infected Patients - This study has been completed (Current: 23 Nov 2006) - Pyrimethamine,Leucovorin calcium
- A Randomized Prospective Study of Pyrimethamine Therapy for Prevention of Toxoplasmic Encephalitis in HIV-Infected Individuals With Serologic Evidence of Latent Toxoplasma Gondii Infection - This study has been completed (Current: 23 Nov 2006) - Pyrimethamine
- A Pilot Study of Oral Clindamycin and Pyrimethamine for the Treatment of Toxoplasmic Encephalitis in Patients With AIDS - This study has been completed (Current: 23 Nov 2006) - Pyrimethamine,Leucovorin calcium,Clindamycin
- A Study of Azithromycin Plus Pyrimethamine in the Treatment of a Brain Infection in Patients With AIDS - This study has been completed (Current: 23 Nov 2006) - Azithromycin,Pyrimethamine,Leucovorin calcium
- A Study of Pyrimethamine in the Treatment of Infection by a Certain Parasite in HIV-Positive Patients - This study has been completed (Current: 23 Nov 2006) - Pyrimethamine,Leucovorin calcium,Zidovudine
- A Pilot Study of 566C80 for the Salvage Treatment of Toxoplasmic Encephalitis in Patients Infected With the Human Immunodeficiency Virus (HIV) Who Have Failed or Are Intolerant of Pyrimethamine-Sulfadiazine - This study has been completed (Current: 23 Nov 2006) - Atovaquone
- Toxoplasmic Encephalitis in Patients With AIDS. Treatment and Prevention of Relapse - This study has been completed (Current: 23 Nov 2006) - Pyrimethamine,Clindamycin
- Phase II Randomized Open-Label Trial of Atovaquone Plus Pyrimethamine and Atovaquone Plus Sulfadiazine for the Treatment of Acute Toxoplasmic Encephalitis - This study has been completed (Current: 23 Nov 2006) - Sulfadiazine,Clarithromycin,Atovaquone,Pyrimethamine,Leucovorin calcium
- Pyrimethamine, Sulfadiazine, and Leucovorin in Treating Patients With Congenital Toxoplasmosis - This study is currently recruiting patients (Current: 23 Nov 2006) - leucovorin calcium,pyrimethamine,spiramycin,sulfadiazine
- Treatment and Outcome of Congenital Toxoplasmosis - This study is currently recruiting patients (Current: 23 Nov 2006) - Folinic acid,Pyrimethamine,Sulfadiazine
- A Study of Three Drugs Plus Zidovudine in the Prevention of Infections in HIV-Infected Patients - This study has been completed (Current: 23 Nov 2006) - Pentamidine isethionate,Sulfamethoxazole-Trimethoprim,Dapsone,Zidovudine
- To Compare Intravitreal Clindamycin & Dexamethasone With Classic Treatment of Toxoplasmic Retinochoroiditis - This study is currently recruiting patients (Current: 23 Nov 2006) - Clindamycin+Dexamethasone,pyrimethamine-sulfadiazine + prednisolone
The format for each of the following is:
- The drug,
- followed by the name of the trial,
- followed by whether the trial is recruiting patients,
- The trial may not have started and not yet recruiting, or the trial may have started and do not need any more recruitements, or the trial may be completed.
- Note**: Please follow the link to determine the current trial status.
ClinicalTrials.gov has listed the following drugs in trials for Toxoplasmosis:
The trial data on this page has been sourced from
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