Clinical Trials for Thyroid disorders
Clinical trials are research studies conducted in an effort to improve overall patient health and care.
Each trial involves running supervised tests to determine the effectiveness and safety of new drugs, procedures and/or devices with the aim of answering scientific questions about a disease or condition.
Risks and side-effects are also evaluated during these trials with results ranging from being unpleasant, with side effects such as headaches, to more serious or even life-threatening risks.
A clinical trial may be separated into phases, or steps, with each step designed to answer a separate research question. This maybe reflected in the trial name.
A brief description of each phase:
- Phase I: Usually designed to evaluate safety, determine a safe dosage range, and identify side effects on a small group of patients.
- Phase II: If Phase I is successful, the trial is then repeated with a larger group to further evaluate its effect and safety.
- Phase III: Trials are conducted on an ever larger group and are compared with the best current treatment while gathering more information on effect and safety.
- Phase IV: These studies monitor long-term side effects after the treatment has been marketed.
Clinical Trials data for Thyroid disorders is grouped into the following categories:-
The format for each of the following is:
- The name of the trial,
- followed by whether the trial is recruiting patients,
- The trial may not have started and not yet recruiting, or the trial may have started and do not need any more recruitements, or the trial may be completed.
- Note**: Please follow the link to determine the current trial status.
- followed by a list of drug/s, if any, used in the trial
ClinicalTrials.gov has listed the following trials for Thyroid disorders:
- Health-Related Quality of Life of Thyroid Patients - This study is currently recruiting patients (Current: 23 Nov 2006)
- Study of Thyrotropin-Releasing Hormone in Normal Volunteers and in Patients With Thyroid or Pituitary Abnormalities - This study is currently recruiting patients (Current: 23 Nov 2006) - TRH (Thyrotropin Releasing Hormone)
- Mohawk Culture, Behavior, Toxicant Exposure and Health - This study is currently recruiting patients (Current: 23 Nov 2006)
- Thyroid and Glucose and Energy Metabolism - This study is currently recruiting patients (Current: 23 Nov 2006) - Liothyronine (T3),Levothyroxine (T4)
- Scientific Protocol for the Study of Thyroid Cancer and Other Thyroid Disease in Belarus Following the Chernobyl Accident - This study is currently recruiting patients (Current: 23 Nov 2006)
- Scientific Protocol for the Study of Thyroid Cancer and Other Thyroid Disease in Ukraine Following the Chernobyl Accident - This study is currently recruiting patients (Current: 23 Nov 2006)
- Phase II Randomized Controlled Study of Sequential Orbital Radiotherapy for Graves' Ophthalmopathy - This study is no longer recruiting patients (Current: 23 Nov 2006)
- TSH Receptor Antibody Heterogeneity in Children and Adolescents With Graves' Disease - This study is currently recruiting patients (Current: 23 Nov 2006)
- Evaluation of Patients With Thyroid Disorders - This study is currently recruiting patients (Current: 23 Nov 2006)
- Studies on Tumors of the Thyroid - This study is currently recruiting patients (Current: 23 Nov 2006)
- Study of Radioiodine (131-I) Uptake Following Administration of Thyrogen and Hypothyroid States During Thyroid Hormone Withdrawal. - This study has been completed (Current: 23 Nov 2006)
- Indium In 111 Pentetreotide in Treating Patients With Refractory Cancer - This study is no longer recruiting patients (Current: 23 Nov 2006) - indium In 111 pentetreotide
- Azacitidine to Restore Thyroid Function in Patients With Persistent or Metastatic Thyroid Cancer - This study is no longer recruiting patients (Current: 23 Nov 2006) - azacitidine,iodine I 131,liothyronine sodium
- Chemotherapy Plus Radiation Therapy in Treating Patients With Previously Untreated Thyroid Cancer - This study is no longer recruiting patients (Current: 23 Nov 2006) - filgrastim,fluorouracil,hydroxyurea,paclitaxel
- Biological Therapy in Treating Patients With Metastatic Cancer - This study is no longer recruiting patients (Current: 23 Nov 2006) - carcinoembryonic antigen RNA-pulsed DC cancer vaccine
- Immunogenetic Factors of Coronary Heart Disease - This study has been completed (Current: 23 Nov 2006)
- Paclitaxel and Cisplatin Plus Radiation Therapy Followed by Filgrastim in Treating Patients With Recurrent Head and Neck Cancer or Lung Cancer - This study is no longer recruiting patients (Current: 23 Nov 2006) - cisplatin,filgrastim,paclitaxel
- Thalidomide in Treating Patients With Thyroid Cancer - This study is no longer recruiting patients (Current: 23 Nov 2006) - thalidomide
- Celecoxib in Treating Patients With Progressive Metastatic Differentiated Thyroid Cancer - This study is no longer recruiting patients (Current: 23 Nov 2006) - celecoxib
- The Effect of Thyroid Hormone on Drug Elimination in Cancer Patients - This study has been completed (Current: 23 Nov 2006)
- Study of the Anti-Angiogenesis Agent AG-013736 in Patients With Metastatic Thyroid Cancer - This study is no longer recruiting patients (Current: 23 Nov 2006) - VEGFR and PDGFR inhibitor
- Subclinical Thyroid Dysfunction and Risk of Myocardial Infarction and Stroke - This study is no longer recruiting patients (Current: 23 Nov 2006)
- Sorafenib (BAY 43-9006) in Treating Patients With Locally Advanced, Metastatic, or Locally Recurrent Thyroid Cancer - This study has been completed (Current: 23 Nov 2006) - sorafenib
- Gefitinib in Treating Patients With Locally Advanced or Metastatic Thyroid Cancer That Did Not Respond to Iodine Therapy - This study is no longer recruiting patients (Current: 23 Nov 2006) - gefitinib
- Efficacy and Tolerability of ZD6474 in Patients With Thyroid Cancer - This study is currently recruiting patients (Current: 23 Nov 2006) - ZD6474
- Thyroxine Titration Study - This study is no longer recruiting patients (Current: 23 Nov 2006) - Thyroxine
- Trial Evaluating Gleevec in Patients With Anaplastic Thyroid Carcinoma - This study is currently recruiting patients (Current: 23 Nov 2006) - Imatinib (Gleevec)
- The Dose of Radioactive Iodine Needed to Ablate the Thyroid Remnant Left Behind After Thyroidectomy - This study is no longer recruiting patients (Current: 23 Nov 2006) - radioiodine
- A Phase 2, Open-Label Study of AMG 706 to Treat Subjects With Locally Advanced or Metastatic Thyroid Cancer - This study is currently recruiting patients (Current: 23 Nov 2006) - AMG 706
- Study of 18F-Fluorodeoxyglucose (FluGlucoScan) in Patients With Cancer or Suspected Cancer - This study is currently recruiting patients (Current: 23 Nov 2006)
- Study of Irofulven Plus Capecitabine in Patients With Advanced Thyroid Cancer - This study is no longer recruiting patients (Current: 23 Nov 2006) - Irofulven + capecitabine
- Suberoylanilide Hydroxamic Acid in Treating Patients With Metastatic and/or Locally Advanced or Locally Recurrent Thyroid Cancer - This study is currently recruiting patients (Current: 23 Nov 2006) - vorinostat
- Study Comparing Thyrogen Versus a Modified Release of Recombinant Human Thyroid Stimulating Hormone - This study is no longer recruiting patients (Current: 23 Nov 2006) - Modified Release rhTSH
- Multicenter Study Differentiated Thyroid Carcinoma - This study has been completed (Current: 23 Nov 2006)
- rhTSH, Thyroid Size, and Radioiodine Therapy in Benign Goiter - This study is no longer recruiting patients (Current: 23 Nov 2006) - Recombinant human thyrotropin (Thyrogen)
- The Effect of Thyroid Hormone Levels in Pregnant Women on the Intelligence Quotient (IQ) of Their Children - This study is currently recruiting patients (Current: 23 Nov 2006)
- Clinical Evaluation of a New Highly Sensitive Thyroglobulin Assay in Differentiated Thyroid Carcinoma - This study has been completed (Current: 23 Nov 2006)
- Rituximab in the Treatment of Graves' Disease - This study is currently recruiting patients (Current: 23 Nov 2006) - Methimazole,Rituximab
- Block-Replacement Therapy During Radioiodine Therapy - This study is currently recruiting patients (Current: 23 Nov 2006) - Methimazole,Levothyroxine
- Antithyroid Drugs During Radioiodine Therapy - This study has been completed (Current: 23 Nov 2006) - Methimazole
- The Role of TSH Receptor, PPAR-r, IGF-1R, IGF and Cytokines in Different Stages of GravesOphthalmopathy - This study is currently recruiting patients (Current: 23 Nov 2006)
- Treatment for Patients With Metastatic Thyroid Cancer - This study is not yet open for patient recruitment (Current: 23 Nov 2006) - AG 6013736
- Comparison of the Safety and Successful Ablation of Thyroid Remnant in Post-Thyroidectomized Euthyroid Patients (i.e. Patients Administered Thyrogen) Versus Hypothyroid Patients (No Thyrogen) Following 131I Administration - This study is no longer recruiting patients (Current: 23 Nov 2006) - Thyrogen + Radioiodine (131I)
- Growth Hormone and GnRH Agonist in Adolescents With Acquired Hypothyroidism - This study is currently recruiting patients (Current: 23 Nov 2006) - Growth hormone,Lupron
- Evaluation Study of L-T3 Utility in the Follow-Up of Patients With Thyroid Cancer - This study is currently recruiting patients (Current: 23 Nov 2006) - Liothyronine
- Thyroid Hormone Dose Adjustment in Pregnancy - This study is currently recruiting patients (Current: 23 Nov 2006) - Anticipatory dose increase of levothyroxine
- Effect of Lithium Carbonate on Low-Dose Radioiodine Therapy in Early Thyroid Cancer - This study is currently recruiting patients (Current: 23 Nov 2006) - Lithium Carbonate
- Selenium Treatment in Autoimmune Thyroiditis (AIT) - This study has been completed (Current: 23 Nov 2006) - L-Selenomethionine
- LISA-Study : Levothyroxin in Nodular Goiter - This study is currently recruiting patients (Current: 23 Nov 2006) - Levothyroxin
- Phase II Study of IMRT With SIB as Adjuvant Treatment for High Risk Resected Well-Differentiated Thyroid Cancer. - This study is currently recruiting patients (Current: 23 Nov 2006)
- Review of Multimodality Management of Anaplastic Thyroid Cancer - This study is currently recruiting patients (Current: 23 Nov 2006)
- Post Partum Thyroiditis 2: Long Term Observations - This study is no longer recruiting patients (Current: 23 Nov 2006)
- Lanreotide (Somatuline Autogel) in Thyroid-Associated Ophthalmopathy Treatment - This study is currently recruiting patients (Current: 23 Nov 2006) - Lanreotide (Autogel formulation). Duration of treatment - 3 injections, 1 every 28 days
- Thyroid Dysfunction in Women With Newly Diagnosed Stage I, Stage II, or Stage III Breast Cancer Who Are Planning to Undergo Chemotherapy Compared to Thyroid Dysfunction in Healthy Volunteers - This study is currently recruiting patients (Current: 23 Nov 2006)
- Studies of Thyroid Abnormalities in Northeastern Kazakstan Associated With Nuclear Weapons Testing - This study is no longer recruiting patients (Current: 23 Nov 2006)
- Thyroid Treatment Trial - This study is currently recruiting patients (Current: 23 Nov 2006) - Intravenous Methylprednisolone + Oral Methotrexate vs Intravenous Methylprednisolone + Placebo
- Imatinib in Combination With Dacarbazine (DTIC) and Capecitabine in Medullary Thyroid Carcinoma (MTC) - This study is currently recruiting patients (Current: 23 Nov 2006) - Capecitabine,Dacarbazine,Imatinib
- Phase II Open Label Thyroid Study - This study is currently recruiting patients (Current: 23 Nov 2006) - ZD6474
- Phase 4 Study in Secondary Hypothyroidism: Body Weight Adapted Thyroxin Treatment and Triiodothyronine Supplementation - This study is no longer recruiting patients (Current: 23 Nov 2006) - Thyroxin,Triiodothyronine
- Comparison of I-124 PET/CT, F-18 FDG PET/CT & I-123 Whole Body Scintigraphy for Recurrent Thyroid CA - This study is not yet open for patient recruitment (Current: 23 Nov 2006)
- Sunitinib in Treating Patients With Thyroid Cancer That Did Not Respond to Iodine I 131 and Cannot Be Removed by Surgery - This study is currently recruiting patients (Current: 23 Nov 2006) - sunitinib malate
- Total Thyroidectomy With Harmonic Scalpel - This study is not yet open for patient recruitment (Current: 23 Nov 2006)
- Thyroid Therapy for Mild Thyroid Deficiency in Pregnancy - This study is currently recruiting patients (Current: 23 Nov 2006) - Levothyroxine
- Phase 2 Study Of AG-013736 In Patients With Doxorubicin-Refractory Or Intolerant Thyroid Cancer - This study is not yet open for patient recruitment (Current: 23 Nov 2006) - AG-013736
- Is the Routine Pressure Dressing After Thyroidectomy Necessary? - This study is not yet open for patient recruitment (Current: 23 Nov 2006)
- Thyroid Function in Term Infants With Respiratory Distress - This study is currently recruiting patients (Current: 23 Nov 2006)
The format for each of the following is:
- The drug,
- followed by the name of the trial,
- followed by whether the trial is recruiting patients,
- The trial may not have started and not yet recruiting, or the trial may have started and do not need any more recruitements, or the trial may be completed.
- Note**: Please follow the link to determine the current trial status.
ClinicalTrials.gov has listed the following drugs in trials for Thyroid disorders:
The trial data on this page has been sourced from
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