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Causes of Thrombocytopenia

Contents
  1. Thrombocytopenia: Introduction
  2. List of Causes
  3. Drugs/substances (93 causes)
  4. Drug interaction (7 causes)
  5. Hidden causes
  6. Excerpts from book chapters
  7. Complication causes
  8. Causes of symptoms
  9. Related cause information

List of causes of Thrombocytopenia

Following is a list of causes or underlying conditions (see also Misdiagnosis of underlying causes of Thrombocytopenia) that could possibly cause Thrombocytopenia includes:

More causes: see full list of causes for Thrombocytopenia

Causes of Thrombocytopenia (Diseases Database):

The follow list shows some of the possible medical causes of Thrombocytopenia that are listed by the Diseases Database:

Source: Diseases Database

Thrombocytopenia Causes: Book Excerpts

Thrombocytopenia as a complication of other conditions:

Other conditions that might have Thrombocytopenia as a complication may, potentially, be an underlying cause of Thrombocytopenia. Our database lists the following as having Thrombocytopenia as a complication of that condition:

Thrombocytopenia as a symptom:

Conditions listing Thrombocytopenia as a symptom may also be potential underlying causes of Thrombocytopenia. Our database lists the following as having Thrombocytopenia as a symptom of that condition:

Medications or substances causing Thrombocytopenia:

The following drugs, medications, substances or toxins are some of the possible causes of Thrombocytopenia as a symptom. This list is incomplete and various other drugs or substances may cause your symptoms. Always advise your doctor of any medications or treatments you are using, including prescription, over-the-counter, supplements, herbal or alternative treatments.

See full list of 93 medications causing Thrombocytopenia


Drug interactions causing Thrombocytopenia:

When combined, certain drugs, medications, substances or toxins may react causing Thrombocytopenia as a symptom.

The list below is incomplete and various other drugs or substances may cause your symptoms. Always advise your doctor of any medications or treatments you are using, including prescription, over-the-counter, supplements, herbal or alternative treatments.

  • Carmustine and Cimetidine interaction
  • Cyclophosphamide and Allopurinol interaction
  • Lomustine and Theophylline interaction
  • Methotrexate and Aspirin interaction
  • Methotrexate and Ciprofloxacin interaction
  • more interactions...»

See full list of 7 drug interactions causing Thrombocytopenia

Related information on causes of Thrombocytopenia:

As with all medical conditions, there may be many causal factors. Further relevant information on causes of Thrombocytopenia may be found in:

Causes of Thrombocytopenia: Online Medical Books

16 MEDICAL BOOKS ONLINE! Review excerpts from medical books online, free, without registration, for more information about the causes of Thrombocytopenia.

Thrombocytopenia: Differential Diagnosis
(In A Page: Pediatric Signs and Symptoms)

Disorders of increased destruction

  • Immunologic platelet consumption
    –Immune thrombocytopenic purpura (ITP)
    –Drug-induced (antiepileptics, septra)
    –Infection (EBV, CMV, malaria, Parvovirus, HIV, other viral illnesses)
    –Autoimmune disease (SLE)
    –Evans syndrome: ITP with immune hemolytic anemia
    –Allergy or anaphylaxis
    –Posttransplant
    • Nonimmunologic
      –Chronic microangiopathic hemolytic anemia
      –Hemolytic-uremic syndrome (HUS)
      –Thrombotic thrombocytopenic purpura
      –Shear (catheters, cardiopulmonary bypass, congenital or acquired heart disease)

    Disorders of decreased production
  • Bone marrow infiltration: Leukemia, neuroblastoma, histiocytosis, osteopetrosis
  • Marrow failure: Aplastic anemia, congenital microangiopathic anemia, thrombocytopenia with absent radii (TAR), Fanconi anemia, myelodysplasia, amegakaryocytic thrombocytopenia
  • Abnormal platelet size or morphology
    –Bernard-Soulier
    –May-Hegglin
    –Gray platelet
    –Wiskott-Aldrich
    • Severe nutritional deficiency
      –B12, folate

    Combined disorders
    • DIC, Kasabach-Merritt syndrome, storage diseases, renal disease, pre-eclampsia

    Sequestration
    • Hypersplenism/portal hypertension, thrombosis, cavernous transformation of portal vein, hypothermia

    Neonatal
  • Congenital anomalies (trisomy 13 or 18)
  • Maternal causes: ITP, SLE, HELLP syndrome, DIC, hyperthyroidism, viral illness, drug use
  • NEC

» READ BOOK EXCERPT ONLINE »

Source: In A Page: Pediatric Signs and Symptoms, 2007

Thrombocytopenia: Causes
(Professional Guide to Diseases (Eighth Edition))

Thrombocytopenia may be congenital or acquired; the acquired form is more common. In either case, it usually results from decreased or defective production of platelets in the marrow (such as occurs in leukemia, aplastic anemia, or toxicity with certain drugs) or from increased destruction outside the marrow caused by an underlying disorder (such as cirrhosis of the liver, disseminated intravascular coagulation, or severe infection). Less commonly, it results from sequestration (hypersplenism and hypothermia) or platelet loss. Acquired thrombocytopenia may result from certain drugs, such as sulfonamides, antibiotics, gold salts, estrogens, or chemotherapeutic agents. (See Causes of decreased circulating platelets, page 1046.)

ELDER TIP In older adults, platelet characteristics change. Granular constituents decrease and platelet-release factors increase. These changes may reflect diminished bone marrow and increased fibrinogen levels.

An idiopathic form of thrombocytopenia commonly occurs in children. A transient form may follow viral infection (such as Epstein-Barr virus or infectious mononucleosis).

» READ BOOK EXCERPT ONLINE »

Source: Professional Guide to Diseases (Eighth Edition), 2005

Thrombocytopenia: Causes
(Handbook of Diseases)

Thrombocytopenia may be congenital or acquired; the acquired form is more common. In either case, it usually results from the following:

❑ decreased or defective production of platelets in the marrow (such as occurs in leukemia, aplastic anemia, or toxicity with certain drugs)

❑ increased destruction outside the marrow caused by an underlying disorder (such as cirrhosis of the liver, disseminated intravascular coagulation, or severe infection)

❑ less commonly, sequestration (hypersplenism, hypothermia) or platelet loss.

Acquired thrombocytopenia may result from certain drugs, such as nonsteroidal anti-inflammatory agents, sulfonamides, histamine blockers, alkylating agents, heparin, alcohol, or antibiotic chemotherapeutic agents.

An idiopathic form of thrombocytopenia commonly occurs in children. A transient form may follow viral infections (Epstein-Barr or infectious mononucleosis).

» READ BOOK EXCERPT ONLINE »

Source: Handbook of Diseases, 2003


 » Next page: Symptoms of Thrombocytopenia

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