Male Hypogonadism
Male Hypogonadism: Excerpt from A Pocket Manual of Differential Diagnosis
Primary
Acquired
Adult seminiferous tubule failure
Amyloidosis
Autoimmune destruction
Cryptorchidism
Drugs
Chemotherapy
Ethanol
Ketoconazole
Marijuana
Spironolactone
Granulomatous disease
Leprosy
Leukemia
Viral orchitis
Mumps
Polyarteritis nodosa
Radiation
Surgery (castration)
Trauma
Developmental
Congenital anorchia
Decreased responsiveness to testosterone (male pseudohermaphroditism)
Reifenstein's syndrome
5
α-Reductase deficiency
Defective testosterone biosynthesis
Functional prepubertal castrate (vanishing testes
syndrome)
Klinefelter's syndrome
Luteinizing hormone (LH) resistant testes
Myotonic dystrophy
Persistent müllerian duct syndrome
Sertoli-cell only syndrome
Ullrich-Noonan syndrome (male Turner syndrome)
XY/XO mixed gonadal dysgenesis
XX male
XYY syndrome
Secondary (Pituitary) or Tertiary (Hypothalamic)
Hypopituitarism
Congenital adrenal hyperplasia
Constitutional delay of puberty
Cushing's syndrome
Estrogen-secreting tumors
Exposure to estrogen in embalming compounds
Fröhlich's syndrome
Hyperprolactinemia
Hypopituitarism
Idiopathic hypogonadotropic hypogonadism (may be adult onset)
Isolated gonadotropin deficiency
Hypogonadotropic eunuchoidism
Complete (Kallman's syndrome)
Partial
Inherited immunologically active, biologically inactive LH
Predominant LH deficiency, “fertile eunuch” syndrome
Variant form (isolated follicle-stimulating hormone deficiency)
Specific genetic syndromes
Bardet-Biedl syndrome
Börjeson-Forssman-Lehman syndrome
Central nervous system (CNS) anomalies, genital hypoplasia, and ear anomalies and/or deafness (CHARGE) syndrome
Laurence-Moon syndrome
Lowe's syndrome
Martsolf syndrome
Möbius syndrome
Multiple lentigines (leopard syndrome)
Prader-Labhart-Willi syndrome
Rothmund-Thomson syndrome
Rud's syndrome
Steroid sulfatase deficiency
Morbid obesity
Pituitary dwarfism
Severe illness (acute or chronic)
Withdrawal of androgen therapy (temporary)
Combined Primary and Secondary
Aging
Cirrhosis
Sickle cell disease
References
1. Plymate SR: Male Hypogonadism, pp. 1057–1079. See Bibliography, 2.
2. Santen RJ: The Testis, pp. 916–935. See Bibliography, 6.
Book Source Details
- Book Title: A Pocket Manual of Differential Diagnosis
- Author(s): Stephen N. Adler, Dianne B. Gasbarra
- Year of Publication: 1999
- Copyright Details: A Pocket Manual of Differential Diagnosis, Copyright © 1999 Lippincott Williams & Wilkins.
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