Clinical Trials for Smoking

Clinical trials are research studies conducted in an effort to improve overall patient health and care. Each trial involves running supervised tests to determine the effectiveness and safety of new drugs, procedures and/or devices with the aim of answering scientific questions about a disease or condition. Risks and side-effects are also evaluated during these trials with results ranging from being unpleasant, with side effects such as headaches, to more serious or even life-threatening risks. A clinical trial may be separated into phases, or steps, with each step designed to answer a separate research question. This maybe reflected in the trial name.

A brief description of each phase:

• Phase I: Usually designed to evaluate safety, determine a safe dosage range, and identify side effects on a small group of patients.
• Phase II: If Phase I is successful, the trial is then repeated with a larger group to further evaluate its effect and safety.
• Phase III: Trials are conducted on an ever larger group and are compared with the best current treatment while gathering more information on effect and safety.
• Phase IV: These studies monitor long-term side effects after the treatment has been marketed.

Clinical Trials data for Smoking is grouped into the following categories:-

• View by trial name
• View by drugs used in Smoking clinical trials

Clinical Trials by trial name

The format for each of the following is:

• The name of the trial,
• followed by whether the trial is recruiting patients,
  - The trial may not have started and not yet recruiting, or the trial may have started and do not need any more recruitements, or the trial may be completed.
  - Note**: Please follow the link to determine the current trial status.
• followed by a list of drug/s, if any, used in the trial

ClinicalTrials.gov has listed the following trials for Smoking:

• Efficacy of Naltrexone in Women's Smoking Cessation - This study is not yet open for patient recruitment (Current: 23 Nov 2006) - Naltrexone (drug)
• Centralized Telephone Outreach to Assist Smoking Cessation Among Veterans - This study has been completed (Current: 23 Nov 2006)
• Implementing Guidelines for Smoking Cessation: A Randomized Trial of Evidence-Based Quality Improvement - This study is no longer recruiting patients (Current: 23 Nov 2006)
• A Randomized Trial to Implement the AHCPR Smoking Cessation Guideline - This study is no longer recruiting patients (Current: 23 Nov 2006)
• Group Therapy for Nicotine Dependence - This study is currently recruiting patients (Current: 23 Nov 2006)
• Brief Smoking Intervention for Women Undergoing Breast Cancer Surgery - This study is not yet open for patient recruitment (Current: 23 Nov 2006)
• Group Counseling for Smoking Cessation - This study is currently recruiting patients (Current: 23 Nov 2006)
• Nurse Smoking Cessation of Patients With Chronic Obstructive Pulmonary Disease (COPD) With Nicotine Replacement Therapy (NRT) and Behavioral Support - This study has been terminated (Current: 23 Nov 2006) - nicotine sublingual tablets
• Theory-Based Interventions for Smoking and Obesity (Challenge) Trial - This study is no longer recruiting patients (Current: 23 Nov 2006)
• Genetic Factors and Interrelationships for Cancer Risk-Related Behaviors and Complex Traits - This study has been completed (Current: 23 Nov 2006)
• Anti-Smoking Program for Parents: Effects on Child Smoking - This study has been completed (Current: 23 Nov 2006)
• Combination Nicotine Replacement for Alcoholic Smokers - This study is currently recruiting patients (Current: 23 Nov 2006) - nicotine patch and nicotine gum
• Global Tobacco Use Survey - This study is currently recruiting patients (Current: 23 Nov 2006)
• Low-Dose Naltrexone Combined With Bupropion to Stop Smoking With Less Weight Gain - This study is no longer recruiting patients (Current: 23 Nov 2006) - Naltrexone,Bupropion
• Linking Lives: Building Quality Parent Components for School-Based Health Programs in Middle Schools - This study is currently recruiting patients (Current: 23 Nov 2006)
• Researching the Youth Smoking Experience - This study is currently recruiting patients (Current: 23 Nov 2006)
• Proactive Health Intervention for Tobacco Users (Get PHIT) - This study is currently recruiting patients (Current: 23 Nov 2006)
• Assessment of Early Genetic Changes in Smokers - This study has been suspended (Current: 23 Nov 2006)
• Checking Smoking Status as a Routine Vital Sign: A Cluster-Randomized Trial of Its Effect on Cessation Counseling - This study has been completed (Current: 23 Nov 2006)
• Baclofen Effects on Smoking Urge and Withdrawal - This study is not yet open for patient recruitment (Current: 23 Nov 2006) - Baclofen
• Bupropion for Hospital-Based Smoking Cessation - This study is currently recruiting patients (Current: 23 Nov 2006) - bupropion
• Exercise, Smoking Cessation and Adolescents - This study is not yet open for patient recruitment (Current: 23 Nov 2006)
• Implementing Tobacco Control in Dental Practice - This study is currently recruiting patients (Current: 23 Nov 2006)
• Organochlorine Exposure in Relation to Timing of Natural Menopause - This study is no longer recruiting patients (Current: 23 Nov 2006)
• Pennsylvania Adolescent Smoking Study (PASStudy) - This study is not yet open for patient recruitment (Current: 23 Nov 2006)
• Testing a Full Substitution Therapy Approach As Treatment of Tobacco Dependence - This study is not yet open for patient recruitment (Current: 23 Nov 2006) - Selegiline
• Quit Smoking - This study is no longer recruiting patients (Current: 23 Nov 2006) - Mecamylamine,Nicotine Patch
• Oxidative Stress and Vitamin E Requirements - This study has been completed (Current: 23 Nov 2006) - Vitamin E with and without Vitamin C
• Combined Nortriptyline and Transdermal Nicotine for Smoking Cessation - This study has been completed (Current: 23 Nov 2006) - nortriptyline
• Combinations of Pharmacologic Smoking Cessation Treatments - This study is no longer recruiting patients (Current: 23 Nov 2006) - Bupropion,Mecamylamine,Nicotine Patch
• Treatment for Smoking - This study is currently recruiting patients (Current: 23 Nov 2006) - patch,nasal spray,inhaler,gum
• Quitlink : A Leveraging Solution to Tobacco Counseling - This study is currently recruiting patients (Current: 23 Nov 2006)
• Hutchinson Smoking Prevention Project - This study has been completed (Current: 23 Nov 2006)
• TeleQuit Smoking Cessation Program - This study is currently recruiting patients (Current: 23 Nov 2006)
• A 12-Week Double-Blind, Placebo-Controlled, Multicenter Study With Varenicline Tartrate 1mg Bid for Smoking Cessation - This study is currently recruiting patients (Current: 23 Nov 2006) - Varenicline
• Bupropion for Hospitalized Smokers With Acute Cardiovascular Disease - This study has been completed (Current: 23 Nov 2006) - bupropion SR (sustained-release)
• Testing Pharmacological Therapies for Pregnant Smokers - This study has been suspended (Current: 23 Nov 2006) - Patient choice of nicotine replacement (patch, gum, lozenge)
• Effectiveness of Nicotine Replacement Therapy in Reducing the Risk of Nicotine Exposure in Pregnant Minority Smokers - This study is currently recruiting patients (Current: 23 Nov 2006)
• Stop Smoking Therapy for Ontario Patients - This study is currently recruiting patients (Current: 23 Nov 2006) - nicotine replacement therapy
• Stop Smoking Therapy for Ontario Patients (STOP) Phase I - This study is currently recruiting patients (Current: 23 Nov 2006) - nicotine replacement
• Risk Perception Among Quitting Smokers - This study is currently recruiting patients (Current: 23 Nov 2006)
• Smoking Cessation in Groups and With Tobacco Pastils - This study is no longer recruiting patients (Current: 23 Nov 2006) - Oliwer Twist smokeless tobacco (tobacco)
• Project Friendship - Adolescent Safer Sex Social Network Intervention - This study is no longer recruiting patients (Current: 23 Nov 2006)
• Tobacco Dependence in Alcoholism Treatment (Nicotine Patch/Naltrexone) - This study is no longer recruiting patients (Current: 23 Nov 2006) - naltrexone (Revia),nicotine replacement patch
• Timing of Smoking Intervention in Alcohol Treatment (Nicotine Patch) - This study is no longer recruiting patients (Current: 23 Nov 2006) - nicotine replacement patch
• Behavioral/Drug Therapy for Alcohol-Nicotine Dependence (Naltrexone/Nicotine Patch) - This study is no longer recruiting patients (Current: 23 Nov 2006) - naltrexone (Revia),nicotine replacement patch
• Smoking Cessation in Alcoholism Treatment - This study has been completed (Current: 23 Nov 2006) - nicotine replacement patch
• Pharmacologic Relapse Prevention for Alcoholic Smokers - This study has been completed (Current: 23 Nov 2006) - nicotine replacement patch,bupropion (Wellbutrin)
• Behavioral Counseling for Alcohol Dependent Smokers (Nicotine Patch) - This study is no longer recruiting patients (Current: 23 Nov 2006) - nicotine replacement patch
• Ultrasound and Motivational Enhancement for Prenatal Smoking Cessation - This study has been completed (Current: 23 Nov 2006)
• Fluoxetine as a Quit Smoking Aid for Depression-Prone Smokers - This study is no longer recruiting patients (Current: 23 Nov 2006) - Fluoxetine
• Naltrexone and Patch for Smokers - This study is no longer recruiting patients (Current: 23 Nov 2006) - Naltrexone Hydrochloride,Transdermal Nicotine
• Bupropion as a Smoking Cessation Aid in Alcoholics - This study is no longer recruiting patients (Current: 23 Nov 2006) - bupropion (Wellbutrin)
• A Study to Investigate a Research Drug as an Aid for Smoking Cessation in Chronic Cigarette Smokers - This study is no longer recruiting patients (Current: 23 Nov 2006) - MK0364
• Multifactorial Intervention on Cardiovascular Risk Factors in Subjects With Peripheral Arterial Disease - This study is no longer recruiting patients (Current: 23 Nov 2006) - Stepwise therapy for dyslipidemia, hypertension and diabetes
• ATP/AMP Challenge in Healthy Non-Smokers, Smokers, Patients With Asthma, and Patients With Chronic Obstructive Pulmonary Disease (COPD) - This study is currently recruiting patients (Current: 23 Nov 2006)
• Evaluation of Lungs of Normal Individuals by Lung Lavage, Brushing and Bronchial Wall Biopsy - This study is currently recruiting patients (Current: 23 Nov 2006)
• Smoking Cessation for Adults With ADHD - This study is currently recruiting patients (Current: 23 Nov 2006) - Methylphenidate (OROS-MPH)
• Smoking and Alcohol Initiation - This study is currently recruiting patients (Current: 23 Nov 2006)
• Increasing Contingency Management Success in Smoking Cessation - This study is currently recruiting patients (Current: 23 Nov 2006)
• A Medical Assistant-Based Program to Promote Healthy Behaviors in Primary Care - This study is currently recruiting patients (Current: 23 Nov 2006)
• Cardiovascular Lifestyle Study: Effects and Expense of a Cardiovascular Risk Reduction Clinic in Primary Care - This study is currently recruiting patients (Current: 23 Nov 2006)
• Improving Health Behaviors Through Telephone Linked Care - This study is currently recruiting patients (Current: 23 Nov 2006)
• Bio-Behavioral Predictors of the Efficacy of Nicotine Replacement Therapy (NRT) - This study is no longer recruiting patients (Current: 23 Nov 2006) - nicotine nasal spray,Transdermal Nicotine Patch
• A Cohort Study of Smoking Prevention and Health Promotion for Middle School Students in Wuhan, China - This study is no longer recruiting patients (Current: 23 Nov 2006)
• An Investigation of Effectiveness and Safety of Varenicline Tartrate in Helping People Quit Smoking - This study is currently recruiting patients (Current: 23 Nov 2006) - Varenicline tartrate,Placebo
• Practicing Self-Control Lowers the Risk of Smoking Lapse - This study is currently recruiting patients (Current: 23 Nov 2006)
• Adjustment of DOses of NIcotine in Smoking Cessation (ADONIS) - This study is not yet open for patient recruitment (Current: 23 Nov 2006)
• Hutchinson Study of High School Smoking - This study is no longer recruiting patients (Current: 23 Nov 2006)
• PROS Brief Smoking Cessation Counseling in Pediatric Practice to Reduce Secondhand Smoke Exposure of Young Children - This study is currently recruiting patients (Current: 23 Nov 2006)
• Smoking Cessation Aid for Young Smokers - This study is no longer recruiting patients (Current: 23 Nov 2006)
• Examining the Effect of the Nicotine Patch in Male and Female Smokers - 3 - This study is currently recruiting patients (Current: 23 Nov 2006) - nicotine transdermal system
• Intervention for Support Persons to Help Smokers Quit - This study is no longer recruiting patients (Current: 23 Nov 2006)
• Protecting the 'Hood Against Tobacco - This study is currently recruiting patients (Current: 23 Nov 2006)
• Smoking Cessation Assistance With LIBERTAL, a Phospholipid Mixture - This study has been terminated (Current: 23 Nov 2006) - LIBERTAL- a phospholipid mixture
• Effect of Ethanol and Genetic Polymorphisms on Bupropion Metabolism - This study is currently recruiting patients (Current: 23 Nov 2006) - Bupropion,Chlorzoxazone,Ethanol
• Efficacy and Safety of Dianicline Versus Placebo as an Aid to Smoking Cessation - This study is currently recruiting patients (Current: 23 Nov 2006) - dianicline
• Efficacy and Cost of State Quitline Policies - This study is no longer recruiting patients (Current: 23 Nov 2006) - NRT patches
• Efficacy and Safety of Dianicline Treatment as an Aid to Smoking Cessation in Cigarette Smokers - This study is currently recruiting patients (Current: 23 Nov 2006) - SSR591813L (dianicline)
• Media Literacy to Prevent Adolescent Smoking - This study is currently recruiting patients (Current: 23 Nov 2006)
• Reduction of Smoking in Hospitalized Schizophrenia Patients - This study is currently recruiting patients (Current: 23 Nov 2006)
• Monoamine Oxidases in Smoking Pregnant Women and Newborns - This study is currently recruiting patients (Current: 23 Nov 2006)
• Quetiapine Decreases Smoking in Patients With Chronic Schizophrenia - This study is currently recruiting patients (Current: 23 Nov 2006) - Quetiapine
• ISTAPS: A Stepped Primary Care Smoking Cessation Intervention - This study is no longer recruiting patients (Current: 23 Nov 2006) - Nicotine Gum and Patch,Bupropion
• PROS Smokebusters: Adolescent Smoking Cessation in Pediatric Primary Care - This study is currently recruiting patients (Current: 23 Nov 2006)
• Efficacy of Proactive Telephone Counseling for Pregnant Smokers Enrolled in a Managed Care Organization - This study has been completed (Current: 23 Nov 2006)
• Analysis of 'Tobacco and Alcohol Tax Law' and Its Impact on Cigarette Consumption - This study has been completed (Current: 23 Nov 2006)
• Comparison of the Efficacy and Safety of 2 Oral Doses of Rimonabant, 5 Mg/Day or 20 Mg/Day, Versus Placebo, as an Aid to Smoking Cessation (STRATUS US) - This study has been completed (Current: 23 Nov 2006) - Rimonabant
• Preventing Postpartum Relapse to Smoking Using Yoga and Cognitive Behavioral Therapy: A Randomized Pilot Study - This study is currently recruiting patients (Current: 23 Nov 2006)
• High-Frequency Repetitive Transcranial Magnetic Stimulation Assists In Smoking Cessation - This study is currently recruiting patients (Current: 23 Nov 2006)
• Healthy Outcomes of Pregnancy Education - This study is no longer recruiting patients (Current: 23 Nov 2006)
• Smoking Abstinence and Response to Smoking Cues - This study is currently recruiting patients (Current: 23 Nov 2006)
• Facilitating Implementation of the PHS Smoking Cessation Guidelines - RESET - This study is no longer recruiting patients (Current: 23 Nov 2006)
• Smoking Cessation Interventions in Dental Clinic Smokers - This study is no longer recruiting patients (Current: 23 Nov 2006)
• Mood and Smoking: A Comparison of Smoking Cessation Treatments - This study is currently recruiting patients (Current: 23 Nov 2006) - Nicotine Replacement therapy
• Dose Response Study - This study has been completed (Current: 23 Nov 2006) - varenicline
• A Twelve-Week Study of Varenicline for Safety and Efficacy in Comparison With Placebo for Smoking Cessation - This study has been completed (Current: 23 Nov 2006) - smoking cessation
• A Twelve-Week Study of Varenicline for Safety and Efficacy in Comparison With Placebo and Zyban for Smoking Cessation - This study has been completed (Current: 23 Nov 2006) - smoking cessation
• A 52-Week Multicenter Study Evaluating the Safety and Efficacy of Varenicline for the Maintenance of Smoking Cessation - This study has been completed (Current: 23 Nov 2006) - smoking cessation
• A 52-Week Placebo-Controlled Study Evaluating the Safety of Varenicline - This study has been completed (Current: 23 Nov 2006) - smoking cessation
• An Open Label Study That Compares Varenicline to Transdermal Nicotine Patch for Smoking Cessation - This study is no longer recruiting patients (Current: 23 Nov 2006) - smoking cessation
• A Twelve-Week Study of Varenicline for Safety and Efficacy in Comparison With Placebo and Zyban for Smoking Cessation - This study has been completed (Current: 23 Nov 2006) - smoking cessation
• 12 Week Evaluation of the Safety and Efficacy of a Flexible Dose of CP-526,555 and Placebo for Smoking Cessation - This study has been completed (Current: 23 Nov 2006) - Smoking Cessation
• A Seven-Week Study Evaluating Three Doses of an Experimental Drug Compared With Placebo and Zyban for Smoking Cessation - This study has been completed (Current: 23 Nov 2006) - Smoking Cessation
• 12 Week Evaluation of the Safety and Efficacy of 4 Dosing Strategies of CP-526,555 and Placebo for Smoking Cessation. - This study has been completed (Current: 23 Nov 2006) - Smoking Cessation
• Effectiveness of Reducing Smoking in Facilitating Smoking Cessation in Adolescents - 2 - This study is currently recruiting patients (Current: 23 Nov 2006)
• Effectiveness of Various Smoking Cessation Therapies in Reducing Smoking in Adolescents - 1 - This study is currently recruiting patients (Current: 23 Nov 2006) - Nicotine Cessation Therapies
• Nalmefene Smoking Cessation Study - This study is currently recruiting patients (Current: 23 Nov 2006) - nalmefene
• Effectiveness of the Nicotine Patch in Suppressing Nicotine Withdrawal Symptoms in Women Versus Men - 1 - This study has been completed (Current: 23 Nov 2006) - nicotine transdermal system
• Safety and Effectiveness of NicVAX in Treating Nicotine Dependent Individuals - This study is no longer recruiting patients (Current: 23 Nov 2006)
• The Whole Day First Grade Program - This study has been completed (Current: 23 Nov 2006)
• Safety and Efficacy Study of Topiramate to Aid in Smoking Cessation - This study is no longer recruiting patients (Current: 23 Nov 2006) - Topiramate
• Effectiveness and Safety of Varenicline in Smokers With Cardiovascular Disease Who Wish to Quit Smoking - This study is currently recruiting patients (Current: 23 Nov 2006) - Varenicline,Placebo
• Gradual Vs. Abrupt Cessation Treatment for Smoking - This study is currently recruiting patients (Current: 23 Nov 2006) - Commit Nicotine Lozenges
• Effectiveness of Bupropion for Smokers Recovering From Alcohol Dependence - This study is currently recruiting patients (Current: 23 Nov 2006) - Bupropion
• Efficacy of NicVAX in Smokers Who Want to Quit Smoking - This study is currently recruiting patients (Current: 23 Nov 2006)
• Bio-Behavioral Lung Cancer Prevention Program - This study has been completed (Current: 23 Nov 2006) - zyban
• Quit Smoking Program for Lung Cancer Patients' Families (The Family Ties Project) - This study is no longer recruiting patients (Current: 23 Nov 2006)
• Anxiety Sensitivity Program for Smoking Cessation - This study is currently recruiting patients (Current: 23 Nov 2006)
• Primary Care Physicians' Use of Stop-Smoking Plans to Help Patients Who Are Smokers - This study is no longer recruiting patients (Current: 23 Nov 2006)
• A Comprehensive Practice-Friendly Model for Promoting Healthy Behaviors - This study is not yet open for patient recruitment (Current: 23 Nov 2006)
• Chronic and Acute Effects of Smoking on the Left and Right Ventricular Relaxation in Young Healthy Smokers - This study has been completed (Current: 23 Nov 2006)
• Non-Nicotine Agents for Smoking Cessation - This study is currently recruiting patients (Current: 23 Nov 2006) - bupropion and transdermal patch,transdermal patch and nicotine inhaler
• Financial Incentives for Smoking Cessation - This study is currently recruiting patients (Current: 23 Nov 2006)
• Impact of Lung Cancer Diagnosis on Relatives' Understanding of Genetic Risk and Receptivity to Quit Smoking - This study is currently recruiting patients (Current: 23 Nov 2006)
• Tobacco Use Among Arab American Youth - This study is currently recruiting patients (Current: 23 Nov 2006)
• Longitudinal Care: Smoking Reduction to Aid Cessation - This study is currently recruiting patients (Current: 23 Nov 2006)
• Endothelial Progenitor Cells and Risk Factors for Coronary Artery Disease - This study has been completed (Current: 23 Nov 2006)
• Genetic Mechanisms of Chronic Obstructive Pulmonary Disease (COPD) - This study has been completed (Current: 23 Nov 2006)
• p450 Mediated Lung Toxicity - This study has been suspended (Current: 23 Nov 2006)
• Health Effects of Particulate Acids in Late Adolescence - This study has been completed (Current: 23 Nov 2006)
• Targeted Interventions for Weight-Concerned Smokers - This study is currently recruiting patients (Current: 23 Nov 2006) - Naltrexone,Transdermal nicotine replacement
• Rosiglitazone Versus Theophylline in Asthmatic Smokers - This study is currently recruiting patients (Current: 23 Nov 2006) - rosiglitazone,theophylline
• Effect of Switch to Aripiprazole on Health and Smoking Parameters in Patients With Schizophrenia: A Pilot Study - This study is currently recruiting patients (Current: 23 Nov 2006) - Aripiprazole
• Family Risk Analysis of Substance Use in ADHD Youth Treated With Concerta - This study is currently recruiting patients (Current: 23 Nov 2006)
• Enhancing Tobacco Abstinence Following Hospitalization - This study has been completed (Current: 23 Nov 2006)
• Effectiveness of Using Reduced Nicotine Cigarettes in Men and Women Smokers to Combat Nicotine Addiction - This study is currently recruiting patients (Current: 23 Nov 2006)
• Genetic Epidemiology of Lung Cancer and Smoking - This study is currently recruiting patients (Current: 23 Nov 2006)
• Treatment With Mecamylamine in Smoking and Non-Smoking Alcohol Dependent Patients - This study is currently recruiting patients (Current: 23 Nov 2006) - mecamylamine
• Measuring Smoking Behavior in People With Schizophrenia - This study is not yet open for patient recruitment (Current: 23 Nov 2006)
• Imaging of Brain Receptors in Healthy Volunteers and in Patients With Schizophrenia - This study has been completed (Current: 23 Nov 2006) - SPECT Imaging of Nicotinic Acetylcholine Receptors in Brain
• Prevention of Cigarette Smoking in ADHD Youth With Concerta - This study is currently recruiting patients (Current: 23 Nov 2006) - methylphenidate HCl (Concerta)
• Nicotinic Receptor Augmentation of SSRI Antidepressants - This study is currently recruiting patients (Current: 23 Nov 2006) - Mecamylamine hydrochloride (Inversine)
• Risk Factors for Non-HIV-Related Kaposi's Sarcoma - This study is currently recruiting patients (Current: 23 Nov 2006)
• Obesity Prevention After Smoking Cessation in Menopause - This study has been completed (Current: 23 Nov 2006)
• Measurement of SmokingInduced Neutrophil Activation - This study is currently recruiting patients (Current: 23 Nov 2006) - predisolone
• A Comparison of Bupropion SR and Placebo for Smoking Cessation - This study is currently recruiting patients (Current: 23 Nov 2006) - bupropion sr
• Effectiveness of GW468816, an NMDA Glycine Site Antagonist, for Prevention of Relapse to Smoking - This study is not yet open for patient recruitment (Current: 23 Nov 2006) - Therapies for Relapse to Nicotine
• NC Enhanced WISEWOMAN Project - This study is no longer recruiting patients (Current: 23 Nov 2006)
• Implementation of an Evidence Based Smoking Cessation Strategy (SMOCC) for Patients With COPD in Primary Care - This study is not yet open for patient recruitment (Current: 23 Nov 2006)
• Strategies to Help Adult ED Patients Quit Smoking - This study is currently recruiting patients (Current: 23 Nov 2006) - transdermal nicotine patches
• ROSCAP: Reduction of Smoking in Cardiac Patients Study - This study has been completed (Current: 23 Nov 2006)
• Safety and Effectiveness of Sustained Release Bupropion in Treating Individuals With Schizophrenia Who Smoke - This study is no longer recruiting patients (Current: 23 Nov 2006) - SR Bupropion
• Nicotine Patch and Bupropion to Reduce Smoking Rates in Younger, Low-Income, and Minority Individuals - This study is currently recruiting patients (Current: 23 Nov 2006) - Nicotine Patch,Sustained Release Bupropion
• Smoking Cessation With Smokeless Tobacco, Nicotine Tablets and Nicotine Patches - This study is not yet open for patient recruitment (Current: 23 Nov 2006) - Smokeless tobacco (Oliver Twist pellets)
• Smoking Relapse Prevention in Schizophrenia - This study is currently recruiting patients (Current: 23 Nov 2006) - bupropion,transdermal nicotine patch,short-acting nicotine replacement therapy
• Nicotine Replacement Therapy for Smoking Cessation in Schizophrenia - This study is no longer recruiting patients (Current: 23 Nov 2006) - bupropion, transdermal nicotine patch
• Combined Pharmaco/Behavior Therapy in Adolescent Smokers - This study is currently recruiting patients (Current: 23 Nov 2006) - Bupropion SR
• Study of the Efficiency of Education About Cardiovascular Risk Factors in Patients After an Acute Coronary Syndrome - This study is not yet open for patient recruitment (Current: 23 Nov 2006)
• How Smoking Causes COPD: Examination of Immune System Changes - This study is currently recruiting patients (Current: 23 Nov 2006)
• Tobacco Quitlines:Adjunct to Dental Office Tobacco Intervention - This study is currently recruiting patients (Current: 23 Nov 2006)
• Tobacco Cessation Via Doctors of Chiropractic - This study is currently recruiting patients (Current: 23 Nov 2006)
• Smoking While on Transdermal Nicotine Replacement Therapy: Effects on Craving and Cessation - This study is currently recruiting patients (Current: 23 Nov 2006) - Nicoderm
• Physician-Initiated Stop-Smoking Program for Patients Receiving Treatment for Early-Stage Cancer - This study is no longer recruiting patients (Current: 23 Nov 2006) - nicotine
• Determining the Risk Factors Such as Smoking, Alcohol, and Caffeine and Their Association With Osteoporosis in Men - This study has been completed (Current: 23 Nov 2006)
• Comparing Smoking Treatment Programs for Lighter Smokers - 1 - This study is currently recruiting patients (Current: 23 Nov 2006) - nicotine transdermal system or bupropion
• The Effects of Craving and Abstinence From Cigarettes on Brain Metabolism in Smokers. - This study is currently recruiting patients (Current: 23 Nov 2006) - Bupropion (Zyban)

Drugs used in Clinical Trials for Smoking

The format for each of the following is:

• The drug,
• followed by the name of the trial,
• followed by whether the trial is recruiting patients,
  - The trial may not have started and not yet recruiting, or the trial may have started and do not need any more recruitements, or the trial may be completed.
  - Note**: Please follow the link to determine the current trial status.

ClinicalTrials.gov has listed the following drugs in trials for Smoking:

• Aripiprazole - Effect of Switch to Aripiprazole on Health and Smoking Parameters in Patients With Schizophrenia: A Pilot Study - This study is currently recruiting patients (Current: 23 Nov 2006)
• Baclofen - Baclofen Effects on Smoking Urge and Withdrawal - This study is not yet open for patient recruitment (Current: 23 Nov 2006)
• Bupropion (Wellbutrin) - Bupropion as a Smoking Cessation Aid in Alcoholics - This study is no longer recruiting patients (Current: 23 Nov 2006)
• Bupropion (Wellbutrin) - Pharmacologic Relapse Prevention for Alcoholic Smokers - This study has been completed (Current: 23 Nov 2006)
• Bupropion (Zyban) - The Effects of Craving and Abstinence From Cigarettes on Brain Metabolism in Smokers. - This study is currently recruiting patients (Current: 23 Nov 2006)
• Bupropion And Transdermal Patch - Non-Nicotine Agents for Smoking Cessation - This study is currently recruiting patients (Current: 23 Nov 2006)
• Bupropion SR - Combined Pharmaco/Behavior Therapy in Adolescent Smokers - This study is currently recruiting patients (Current: 23 Nov 2006)
• Bupropion Sr (Sustained-Release) - Bupropion for Hospitalized Smokers With Acute Cardiovascular Disease - This study has been completed (Current: 23 Nov 2006)
• Bupropion Sr - A Comparison of Bupropion SR and Placebo for Smoking Cessation - This study is currently recruiting patients (Current: 23 Nov 2006)
• Bupropion, Transdermal Nicotine Patch - Nicotine Replacement Therapy for Smoking Cessation in Schizophrenia - This study is no longer recruiting patients (Current: 23 Nov 2006)
• Bupropion - Bupropion for Hospital-Based Smoking Cessation - This study is currently recruiting patients (Current: 23 Nov 2006)
• Bupropion - Combinations of Pharmacologic Smoking Cessation Treatments - This study is no longer recruiting patients (Current: 23 Nov 2006)
• Bupropion - Effect of Ethanol and Genetic Polymorphisms on Bupropion Metabolism - This study is currently recruiting patients (Current: 23 Nov 2006)
• Bupropion - Effectiveness of Bupropion for Smokers Recovering From Alcohol Dependence - This study is currently recruiting patients (Current: 23 Nov 2006)
• Bupropion - ISTAPS: A Stepped Primary Care Smoking Cessation Intervention - This study is no longer recruiting patients (Current: 23 Nov 2006)
• Bupropion - Low-Dose Naltrexone Combined With Bupropion to Stop Smoking With Less Weight Gain - This study is no longer recruiting patients (Current: 23 Nov 2006)
• Bupropion - Smoking Relapse Prevention in Schizophrenia - This study is currently recruiting patients (Current: 23 Nov 2006)
• Chlorzoxazone - Effect of Ethanol and Genetic Polymorphisms on Bupropion Metabolism - This study is currently recruiting patients (Current: 23 Nov 2006)
• Commit Nicotine Lozenges - Gradual Vs. Abrupt Cessation Treatment for Smoking - This study is currently recruiting patients (Current: 23 Nov 2006)
• Dianicline - Efficacy and Safety of Dianicline Versus Placebo as an Aid to Smoking Cessation - This study is currently recruiting patients (Current: 23 Nov 2006)
• Ethanol - Effect of Ethanol and Genetic Polymorphisms on Bupropion Metabolism - This study is currently recruiting patients (Current: 23 Nov 2006)
• Fluoxetine - Fluoxetine as a Quit Smoking Aid for Depression-Prone Smokers - This study is no longer recruiting patients (Current: 23 Nov 2006)
• Gum - Treatment for Smoking - This study is currently recruiting patients (Current: 23 Nov 2006)
• Inhaler - Treatment for Smoking - This study is currently recruiting patients (Current: 23 Nov 2006)
• LIBERTAL- a phospholipid mixture - Smoking Cessation Assistance With LIBERTAL, a Phospholipid Mixture - This study has been terminated (Current: 23 Nov 2006)
• MK0364 - A Study to Investigate a Research Drug as an Aid for Smoking Cessation in Chronic Cigarette Smokers - This study is no longer recruiting patients (Current: 23 Nov 2006)
• Mecamylamine hydrochloride (Inversine) - Nicotinic Receptor Augmentation of SSRI Antidepressants - This study is currently recruiting patients (Current: 23 Nov 2006)
• Mecamylamine - Combinations of Pharmacologic Smoking Cessation Treatments - This study is no longer recruiting patients (Current: 23 Nov 2006)
• Mecamylamine - Quit Smoking - This study is no longer recruiting patients (Current: 23 Nov 2006)
• Mecamylamine - Treatment With Mecamylamine in Smoking and Non-Smoking Alcohol Dependent Patients - This study is currently recruiting patients (Current: 23 Nov 2006)
• Methylphenidate (OROS-MPH) - Smoking Cessation for Adults With ADHD - This study is currently recruiting patients (Current: 23 Nov 2006)
• Methylphenidate Hcl (Concerta) - Prevention of Cigarette Smoking in ADHD Youth With Concerta - This study is currently recruiting patients (Current: 23 Nov 2006)
• NRT patches - Efficacy and Cost of State Quitline Policies - This study is no longer recruiting patients (Current: 23 Nov 2006)
• Nalmefene - Nalmefene Smoking Cessation Study - This study is currently recruiting patients (Current: 23 Nov 2006)
• Naltrexone (Revia) - Behavioral/Drug Therapy for Alcohol-Nicotine Dependence (Naltrexone/Nicotine Patch) - This study is no longer recruiting patients (Current: 23 Nov 2006)
• Naltrexone (Revia) - Tobacco Dependence in Alcoholism Treatment (Nicotine Patch/Naltrexone) - This study is no longer recruiting patients (Current: 23 Nov 2006)
• Naltrexone (drug) - Efficacy of Naltrexone in Women's Smoking Cessation - This study is not yet open for patient recruitment (Current: 23 Nov 2006)
• Naltrexone Hydrochloride - Naltrexone and Patch for Smokers - This study is no longer recruiting patients (Current: 23 Nov 2006)
• Naltrexone - Low-Dose Naltrexone Combined With Bupropion to Stop Smoking With Less Weight Gain - This study is no longer recruiting patients (Current: 23 Nov 2006)
• Naltrexone - Targeted Interventions for Weight-Concerned Smokers - This study is currently recruiting patients (Current: 23 Nov 2006)
• Nasal Spray - Treatment for Smoking - This study is currently recruiting patients (Current: 23 Nov 2006)
• Nicoderm - Smoking While on Transdermal Nicotine Replacement Therapy: Effects on Craving and Cessation - This study is currently recruiting patients (Current: 23 Nov 2006)
• Nicotine Cessation Therapies - Effectiveness of Various Smoking Cessation Therapies in Reducing Smoking in Adolescents - 1 - This study is currently recruiting patients (Current: 23 Nov 2006)
• Nicotine Gum and Patch - ISTAPS: A Stepped Primary Care Smoking Cessation Intervention - This study is no longer recruiting patients (Current: 23 Nov 2006)
• Nicotine Nasal Spray - Bio-Behavioral Predictors of the Efficacy of Nicotine Replacement Therapy (NRT) - This study is no longer recruiting patients (Current: 23 Nov 2006)
• Nicotine Patch And Nicotine Gum - Combination Nicotine Replacement for Alcoholic Smokers - This study is currently recruiting patients (Current: 23 Nov 2006)
• Nicotine Patch - Combinations of Pharmacologic Smoking Cessation Treatments - This study is no longer recruiting patients (Current: 23 Nov 2006)
• Nicotine Patch - Nicotine Patch and Bupropion to Reduce Smoking Rates in Younger, Low-Income, and Minority Individuals - This study is currently recruiting patients (Current: 23 Nov 2006)
• Nicotine Patch - Quit Smoking - This study is no longer recruiting patients (Current: 23 Nov 2006)
• Nicotine Replacement Patch - Behavioral Counseling for Alcohol Dependent Smokers (Nicotine Patch) - This study is no longer recruiting patients (Current: 23 Nov 2006)
• Nicotine Replacement Patch - Behavioral/Drug Therapy for Alcohol-Nicotine Dependence (Naltrexone/Nicotine Patch) - This study is no longer recruiting patients (Current: 23 Nov 2006)
• Nicotine Replacement Patch - Pharmacologic Relapse Prevention for Alcoholic Smokers - This study has been completed (Current: 23 Nov 2006)
• Nicotine Replacement Patch - Smoking Cessation in Alcoholism Treatment - This study has been completed (Current: 23 Nov 2006)
• Nicotine Replacement Patch - Timing of Smoking Intervention in Alcohol Treatment (Nicotine Patch) - This study is no longer recruiting patients (Current: 23 Nov 2006)
• Nicotine Replacement Patch - Tobacco Dependence in Alcoholism Treatment (Nicotine Patch/Naltrexone) - This study is no longer recruiting patients (Current: 23 Nov 2006)
• Nicotine Replacement Therapy - Stop Smoking Therapy for Ontario Patients - This study is currently recruiting patients (Current: 23 Nov 2006)
• Nicotine Replacement therapy - Mood and Smoking: A Comparison of Smoking Cessation Treatments - This study is currently recruiting patients (Current: 23 Nov 2006)
• Nicotine Replacement - Stop Smoking Therapy for Ontario Patients (STOP) Phase I - This study is currently recruiting patients (Current: 23 Nov 2006)
• Nicotine Sublingual Tablets - Nurse Smoking Cessation of Patients With Chronic Obstructive Pulmonary Disease (COPD) With Nicotine Replacement Therapy (NRT) and Behavioral Support - This study has been terminated (Current: 23 Nov 2006)
• Nicotine Transdermal System Or Bupropion - Comparing Smoking Treatment Programs for Lighter Smokers - 1 - This study is currently recruiting patients (Current: 23 Nov 2006)
• Nicotine Transdermal System - Effectiveness of the Nicotine Patch in Suppressing Nicotine Withdrawal Symptoms in Women Versus Men - 1 - This study has been completed (Current: 23 Nov 2006)
• Nicotine Transdermal System - Examining the Effect of the Nicotine Patch in Male and Female Smokers - 3 - This study is currently recruiting patients (Current: 23 Nov 2006)
• Nicotine - Physician-Initiated Stop-Smoking Program for Patients Receiving Treatment for Early-Stage Cancer - This study is no longer recruiting patients (Current: 23 Nov 2006)
• Nortriptyline - Combined Nortriptyline and Transdermal Nicotine for Smoking Cessation - This study has been completed (Current: 23 Nov 2006)
• Oliwer Twist smokeless tobacco (tobacco) - Smoking Cessation in Groups and With Tobacco Pastils - This study is no longer recruiting patients (Current: 23 Nov 2006)
• Patch - Treatment for Smoking - This study is currently recruiting patients (Current: 23 Nov 2006)
• Patient choice of nicotine replacement (patch, gum, lozenge) - Testing Pharmacological Therapies for Pregnant Smokers - This study has been suspended (Current: 23 Nov 2006)
• Placebo - An Investigation of Effectiveness and Safety of Varenicline Tartrate in Helping People Quit Smoking - This study is currently recruiting patients (Current: 23 Nov 2006)
• Placebo - Effectiveness and Safety of Varenicline in Smokers With Cardiovascular Disease Who Wish to Quit Smoking - This study is currently recruiting patients (Current: 23 Nov 2006)
• Predisolone - Measurement of SmokingInduced Neutrophil Activation - This study is currently recruiting patients (Current: 23 Nov 2006)
• Quetiapine - Quetiapine Decreases Smoking in Patients With Chronic Schizophrenia - This study is currently recruiting patients (Current: 23 Nov 2006)
• Rimonabant - Comparison of the Efficacy and Safety of 2 Oral Doses of Rimonabant, 5 Mg/Day or 20 Mg/Day, Versus Placebo, as an Aid to Smoking Cessation (STRATUS US) - This study has been completed (Current: 23 Nov 2006)
• Rosiglitazone - Rosiglitazone Versus Theophylline in Asthmatic Smokers - This study is currently recruiting patients (Current: 23 Nov 2006)
• SPECT Imaging of Nicotinic Acetylcholine Receptors in Brain - Imaging of Brain Receptors in Healthy Volunteers and in Patients With Schizophrenia - This study has been completed (Current: 23 Nov 2006)
• SR Bupropion - Safety and Effectiveness of Sustained Release Bupropion in Treating Individuals With Schizophrenia Who Smoke - This study is no longer recruiting patients (Current: 23 Nov 2006)
• SSR591813L (dianicline) - Efficacy and Safety of Dianicline Treatment as an Aid to Smoking Cessation in Cigarette Smokers - This study is currently recruiting patients (Current: 23 Nov 2006)
• Selegiline - Testing a Full Substitution Therapy Approach As Treatment of Tobacco Dependence - This study is not yet open for patient recruitment (Current: 23 Nov 2006)
• Short-Acting Nicotine Replacement Therapy - Smoking Relapse Prevention in Schizophrenia - This study is currently recruiting patients (Current: 23 Nov 2006)
• Smokeless tobacco (Oliver Twist pellets) - Smoking Cessation With Smokeless Tobacco, Nicotine Tablets and Nicotine Patches - This study is not yet open for patient recruitment (Current: 23 Nov 2006)
• Smoking Cessation - 12 Week Evaluation of the Safety and Efficacy of 4 Dosing Strategies of CP-526,555 and Placebo for Smoking Cessation. - This study has been completed (Current: 23 Nov 2006)
• Smoking Cessation - 12 Week Evaluation of the Safety and Efficacy of a Flexible Dose of CP-526,555 and Placebo for Smoking Cessation - This study has been completed (Current: 23 Nov 2006)
• Smoking Cessation - A 52-Week Multicenter Study Evaluating the Safety and Efficacy of Varenicline for the Maintenance of Smoking Cessation - This study has been completed (Current: 23 Nov 2006)
• Smoking Cessation - A 52-Week Placebo-Controlled Study Evaluating the Safety of Varenicline - This study has been completed (Current: 23 Nov 2006)
• Smoking Cessation - A Seven-Week Study Evaluating Three Doses of an Experimental Drug Compared With Placebo and Zyban for Smoking Cessation - This study has been completed (Current: 23 Nov 2006)
• Smoking Cessation - A Twelve-Week Study of Varenicline for Safety and Efficacy in Comparison With Placebo and Zyban for Smoking Cessation - This study has been completed (Current: 23 Nov 2006)
• Smoking Cessation - A Twelve-Week Study of Varenicline for Safety and Efficacy in Comparison With Placebo and Zyban for Smoking Cessation - This study has been completed (Current: 23 Nov 2006)
• Smoking Cessation - A Twelve-Week Study of Varenicline for Safety and Efficacy in Comparison With Placebo for Smoking Cessation - This study has been completed (Current: 23 Nov 2006)
• Smoking Cessation - An Open Label Study That Compares Varenicline to Transdermal Nicotine Patch for Smoking Cessation - This study is no longer recruiting patients (Current: 23 Nov 2006)
• Stepwise therapy for dyslipidemia, hypertension and diabetes - Multifactorial Intervention on Cardiovascular Risk Factors in Subjects With Peripheral Arterial Disease - This study is no longer recruiting patients (Current: 23 Nov 2006)
• Sustained Release Bupropion - Nicotine Patch and Bupropion to Reduce Smoking Rates in Younger, Low-Income, and Minority Individuals - This study is currently recruiting patients (Current: 23 Nov 2006)
• Theophylline - Rosiglitazone Versus Theophylline in Asthmatic Smokers - This study is currently recruiting patients (Current: 23 Nov 2006)
• Therapies for Relapse to Nicotine - Effectiveness of GW468816, an NMDA Glycine Site Antagonist, for Prevention of Relapse to Smoking - This study is not yet open for patient recruitment (Current: 23 Nov 2006)
• Topiramate - Safety and Efficacy Study of Topiramate to Aid in Smoking Cessation - This study is no longer recruiting patients (Current: 23 Nov 2006)
• Transdermal Nicotine Patch - Bio-Behavioral Predictors of the Efficacy of Nicotine Replacement Therapy (NRT) - This study is no longer recruiting patients (Current: 23 Nov 2006)
• Transdermal Nicotine Patch - Smoking Relapse Prevention in Schizophrenia - This study is currently recruiting patients (Current: 23 Nov 2006)
• Transdermal Nicotine Patches - Strategies to Help Adult ED Patients Quit Smoking - This study is currently recruiting patients (Current: 23 Nov 2006)
• Transdermal Nicotine - Naltrexone and Patch for Smokers - This study is no longer recruiting patients (Current: 23 Nov 2006)
• Transdermal Patch And Nicotine Inhaler - Non-Nicotine Agents for Smoking Cessation - This study is currently recruiting patients (Current: 23 Nov 2006)
• Transdermal nicotine replacement - Targeted Interventions for Weight-Concerned Smokers - This study is currently recruiting patients (Current: 23 Nov 2006)
• Varenicline tartrate - An Investigation of Effectiveness and Safety of Varenicline Tartrate in Helping People Quit Smoking - This study is currently recruiting patients (Current: 23 Nov 2006)
• Varenicline - A 12-Week Double-Blind, Placebo-Controlled, Multicenter Study With Varenicline Tartrate 1mg Bid for Smoking Cessation - This study is currently recruiting patients (Current: 23 Nov 2006)
• Varenicline - Dose Response Study - This study has been completed (Current: 23 Nov 2006)
• Varenicline - Effectiveness and Safety of Varenicline in Smokers With Cardiovascular Disease Who Wish to Quit Smoking - This study is currently recruiting patients (Current: 23 Nov 2006)
• Vitamin E with and without Vitamin C - Oxidative Stress and Vitamin E Requirements - This study has been completed (Current: 23 Nov 2006)
• Zyban - Bio-Behavioral Lung Cancer Prevention Program - This study has been completed (Current: 23 Nov 2006)

The trial data on this page has been sourced from

• The U.S. National Library of Medicine (NLM) together with ClinicalTrials.gov

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