Clinical Trials for Sepsis

Clinical trials are research studies conducted in an effort to improve overall patient health and care. Each trial involves running supervised tests to determine the effectiveness and safety of new drugs, procedures and/or devices with the aim of answering scientific questions about a disease or condition. Risks and side-effects are also evaluated during these trials with results ranging from being unpleasant, with side effects such as headaches, to more serious or even life-threatening risks. A clinical trial may be separated into phases, or steps, with each step designed to answer a separate research question. This maybe reflected in the trial name.

A brief description of each phase:

• Phase I: Usually designed to evaluate safety, determine a safe dosage range, and identify side effects on a small group of patients.
• Phase II: If Phase I is successful, the trial is then repeated with a larger group to further evaluate its effect and safety.
• Phase III: Trials are conducted on an ever larger group and are compared with the best current treatment while gathering more information on effect and safety.
• Phase IV: These studies monitor long-term side effects after the treatment has been marketed.

Clinical Trials data for Sepsis is grouped into the following categories:-

• View by trial name
• View by drugs used in Sepsis clinical trials

Clinical Trials by trial name

The format for each of the following is:

• The name of the trial,
• followed by whether the trial is recruiting patients,
  - The trial may not have started and not yet recruiting, or the trial may have started and do not need any more recruitements, or the trial may be completed.
  - Note**: Please follow the link to determine the current trial status.
• followed by a list of drug/s, if any, used in the trial

ClinicalTrials.gov has listed the following trials for Sepsis:

• A Safety and Efficacy Study of Intravenous E5564 in Patients With Severe Sepsis - This study has been completed (Current: 23 Nov 2006) - E5564
• The Effects of EPA, GLA and Antioxidants in the Treatment of Sepsis - This study is not yet open for patient recruitment (Current: 23 Nov 2006) - Eicosapenaenoic acid (EPA), Gamma-Linolenic Acid (GLA) and Antioxidants (Study Group)
• Observational Study of Sepsis and Pneumonia to Develop Diagnostic Tests - This study is currently recruiting patients (Current: 23 Nov 2006)
• Multicenter, Double-Blind, Placebo-Controlled Study To Evaluate Efficacy & Safety Of TAK-242 In Adults With Severe Sepsis - This study is currently recruiting patients (Current: 23 Nov 2006) - TAK-242
• BaSES Trial: Basel Starch Evaluation in Sepsis - This study is currently recruiting patients (Current: 23 Nov 2006) - hydroxy-ethyl starch (MW 130; 0.4) vs. normal saline
• Protocol-Driven Hemodynamic Support for Patients With Septic Shock - This study is not yet open for patient recruitment (Current: 23 Nov 2006)
• Cysteine Supplementation in Critically Ill Neonates - This study is not yet open for patient recruitment (Current: 23 Nov 2006) - Parenteral cysteine-HCl supplementation
• Sepsis: Prognosis and Evaluation of Early Diagnosis and Intervention (SPEEDI Study) - This study is no longer recruiting patients (Current: 23 Nov 2006)
• Effects of Endotoxin in Normal Human Volunteers - This study is no longer recruiting patients (Current: 23 Nov 2006) - Reference Endotoxin,Inhaled Nitric Oxide
• Skin Cleansing With Chlorhexidine to Decrease Hospital Acquired Infections - This study is currently recruiting patients (Current: 23 Nov 2006) - 2% chlorhexidine gluconate impregnated cloth
• Skeletal Muscle Oxygenation in Critically Ill - This study is currently recruiting patients (Current: 23 Nov 2006)
• Effect of Hyperglycemia in PAI-1 Activity and the Relationship With Outcome in Severe Sepsis and Septic Shock - This study is currently recruiting patients (Current: 23 Nov 2006)
• Clinical Trial of the Optimal Endpoint of Early Sepsis Resuscitation - This study is not yet open for patient recruitment (Current: 23 Nov 2006)
• Hydrocortisone Versus Hydrocortisone Plus Fludrocortisone for the Treatment of Adrenal Insufficiency in Severe Sepsis - This study is currently recruiting patients (Current: 23 Nov 2006) - Fludrocortisone
• Efficacy of Volume Substitution and Insulin Therapy in Severe Sepsis (VISEP Trial) - This study has been completed (Current: 23 Nov 2006) - 10% Hemohes® (10% Hydroxyethyl starch),Sterofundin® (Ringer lactate solution),Actrapid® (Insulin)
• Trial of Prophylactic Versus Empirical Vancomycin for the Prevention of Streptococcal Sepsis After Hematopoietic Cell Transplantation - This study has been completed (Current: 23 Nov 2006) - Empirical Vancomycin,Prophylactic Vancomycin
• A Non-Invasive Approach to the Assessment of Volume Status in Mechanically Ventilated Septic Patients. - This study is no longer recruiting patients (Current: 23 Nov 2006)
• Effect of Rosuvastatin in Abdominal Sepsis - This study is currently recruiting patients (Current: 23 Nov 2006) - Rosuvastatin
• Phase I Study of Vasoactive Intestinal Peptide in Patients With Acute Respiratory Distress Syndrome and Sepsis - This study is currently recruiting patients (Current: 23 Nov 2006) - vasoactive intestinal peptide
• Glutamine Supplementation to Prevent Death or Infection in Extremely Premature Infants - This study has been completed (Current: 23 Nov 2006) - Glutamine
• Study of the Relationship Between Feeding and Late Onset Sepsis and/or Necrotizing Enterocolitis in Low Birth Weight Infants - This study has been completed (Current: 23 Nov 2006)
• Prevention of Infection in Indian Neonates - This study is currently recruiting patients (Current: 23 Nov 2006)
• Unfractioned Heparin for Treatment of Sepsis - This study is currently recruiting patients (Current: 23 Nov 2006) - unfractioned heparin
• Chlorhexidine Vaginal and Infant Wash in Pakistan - This study is currently recruiting patients (Current: 23 Nov 2006)
• Impact of Hydrocortisone Administration on White Blood Cell Gene Expression in Patients With Severe Sepsis - This study is currently recruiting patients (Current: 23 Nov 2006) - Hydrocortisone Administration (Standard of Care Therapy)
• Regulation of Endocrine, Metabolic, Immune and Bioenergetic Responses in Sepsis - This study is currently recruiting patients (Current: 23 Nov 2006)
• Procalcitonin-Guided Antimicrobial Discontinuation - This study is not yet open for patient recruitment (Current: 23 Nov 2006)
• Pro-Calcitonin Levels Following Pediatric Cardiac Surgery - This study is currently recruiting patients (Current: 23 Nov 2006)
• Intravenous Clarithromycin in Septic Syndrome - This study has been completed (Current: 23 Nov 2006) - Intravenous Clarithromycin
• Oxytocin Effects on Cytokines and Endocrine Parameters After LPS Induced Systemic Inflammatory Effects in Healthy Volunteers - This study is currently recruiting patients (Current: 23 Nov 2006) - oxytocin
• CRISIS Prevention Study - This study is not yet open for patient recruitment (Current: 23 Nov 2006) - Metoclopramide,Zinc,Glutamine,Selenium
• Safety and Efficacy of Recombinant Human Platelet-Activating Factor Acetylhydrolase for the Treatment of Severe Sepsis - This study has been terminated (Current: 23 Nov 2006) - rPAF-AH
• GR270773 In The Treatment Of Suspected Or Confirmed Gram-Negative Severe Sepsis In Adults - This study is no longer recruiting patients (Current: 23 Nov 2006) - Intravenous GR270773- Phospholipid Emulsion
• Prevention of Perinatal Sepsis (PoPS): Evaluation of Chlorhexidine Wipes of Birth Canal and Newborn - This study is currently recruiting patients (Current: 23 Nov 2006) - Chlorhexidine
• Efficacy Study of Community-Based Treatment of Serious Bacterial Infections in Young Infants - This study is currently recruiting patients (Current: 23 Nov 2006) - ceftrioxone, procaine penicillin and gentamicin, oral cotrimoxazole and gentamicin
• Cortisol Control of Human Inflammatory Responses to Endotoxin - This study is currently recruiting patients (Current: 23 Nov 2006) - Intravenous hydrocortisone
• Safety and Efficacy of Veronate Versus Placebo in Preventing Nosocomial Staphylococcal Sepsis in Premature Infants - This study is no longer recruiting patients (Current: 23 Nov 2006) - Veronate
• The Benefit of Adding Fish Oil to the Nutrition of Critically Ill Patients - This study is currently recruiting patients (Current: 23 Nov 2006) - Defined percentage of omega-3-fatty acids
• Pharmacoeconomic Analysis of First Line Meropenem Versus Standard Antibiotic Treatment in Seriously Infected Secondary Nosocomial Sepsis Syndrome Patients. - This study is currently recruiting patients (Current: 23 Nov 2006) - Meropenem
• A Safety and Efficacy Study of Hospitalized Patients With Community-Acquired Pneumonia and Sepsis - This study has been completed (Current: 23 Nov 2006) - Recombinant Chimeric Monoclonal Antibody
• Study of Inhaled Nitric Oxide for Preterm Infants - This study is no longer recruiting patients (Current: 23 Nov 2006) - inhaled nitric oxide
• A Phase IIb Study to Determine the Efficacy and Safety of the Study Drug in Patients With Severe Sepsis - This study has been completed (Current: 23 Nov 2006) - sPLA2 Inhibitor
• Studies of Acute Lung Injury (ALI) and Acute Respiratory Distress Syndrome - This study is currently recruiting patients (Current: 23 Nov 2006) - methylene blue, inhaled nitric oxide
• Comparative Study of the Protein C Pathway in Septic and Non Septic Patients With Organ Failure - This study has been terminated (Current: 23 Nov 2006)
• Safety and Efficacy of MBI 226 for the Prevention of Central Venous Catheter-Related Bloodstream Infections - This study has been completed (Current: 23 Nov 2006) - MBI 226
• A Study To Compare The Effects Of The Infusion Of A Sepsis Drug Between Healthy Adults And Adults With Damaged Livers - This study is currently recruiting patients (Current: 23 Nov 2006) - Intravenous GR270773 - Phospholipid emulsion
• Hemodynamic and Perfusion Response to Drotrecogin Alfa (Activated) in Patients With Septic Shock - This study is currently recruiting patients (Current: 23 Nov 2006) - drotrecogin alfa (activated),placebo
• Norepinephrine Plus Dobutamine Versus Epinephrine Alone for the Management of Septic Shock - This study has been completed (Current: 23 Nov 2006) - Norepinephrine plus Dobutamine vs Epinephrine
• Selenium, as Sodium Selenite, in the Treatment of Septic Shock - This study has been completed (Current: 23 Nov 2006) - Selenium as sodium selenite
• A Prospective, Randomized, Phase III Trial of FLAC (5-Fluorouracil, Leucovorin, Adriamycin, Cytoxan) Chemotherapy With GM-CSF (Granulocyte-Macrophage Colony-Stimulating Factor) Versus PIXY 321 in Advanced Breast Cancer - This study has been completed (Current: 23 Nov 2006)
• The Study of Drotrecogin Alfa (Activated) in a Subpopulation of Adult Patients With Severe Sepsis - This study has been completed (Current: 23 Nov 2006) - Drotrecogin alfa (activated)
• Investigation of the Efficacy and Safety of Drotrecogin Alfa (Activated) in Pediatric Severe Sepsis - This study has been completed (Current: 23 Nov 2006) - Drotrecogin alfa (activated)(recombinant human Activated Protein C)
• A Trial of Heparin in Patients With Severe Sepsis Who Are Undergoing Treatment With Drotrecogin Alfa (Activated) - This study has been completed (Current: 23 Nov 2006) - Drotrecogin Alfa (Activated),Unfractionated heparin,Low molecular weight heparin
• A Safety Evaluation of Xigris in Patients With Blood Cancer Who Develop Severe Infection Related to Bone Marrow Transplantation - This study has been completed (Current: 23 Nov 2006) - Xigris
• Trial of Glutamine and Antioxidant Supplementation in Critically Ill Patients - This study is currently recruiting patients (Current: 23 Nov 2006) - Glutamine,Antioxidants
• Procalcitonin in Diagnosing Bacteremia in the Emergency Department - This study is currently recruiting patients (Current: 23 Nov 2006)
• Extended Therapy of Drotrecogin Alfa (Activated) 4 vs 7 Days Infusion - This study is currently recruiting patients (Current: 23 Nov 2006) - Drotrecogin Alfa (Activated),placebo
• Botswana Pediatric Respiratory Disease and Bloodstream Infection Study - This study is currently recruiting patients (Current: 23 Nov 2006)
• Infection Surveillance in Intensive Care Patients - This study is no longer recruiting patients (Current: 23 Nov 2006)
• Low-Dose Endotoxemia and the Acute Phase Response - This study is no longer recruiting patients (Current: 23 Nov 2006) - E. Coli endotoxin
• Effect of APC and Epo on the Inflammatory Response During Sepsis. - This study is currently recruiting patients (Current: 23 Nov 2006)
• Strict Glucose Control of Pediatric Intensive Care Unit (ICU) Patients - This study has been suspended (Current: 23 Nov 2006)
• The Effect of Intensive Insulin Therapy in the Surgical Critical Care Unit - This study has been completed (Current: 23 Nov 2006) - Novolin R (human recombinant Insulin)
• Genetic Variation and Immune Responses After Injury - This study is currently recruiting patients (Current: 23 Nov 2006)
• Thrombin Generation and Thromboelastography in Non-Overt DIC - This study is not yet open for patient recruitment (Current: 23 Nov 2006)
• Probiotics for the Prevention of Premature Birth and Neonatal Related Morbidity - This study is currently recruiting patients (Current: 23 Nov 2006) - Lactobacillus rhamnosus GR1 and Lactobacillus reuteri RC-14
• Fluconazole Versus Micafungin for Candida Bloodstream Infection in Non-Neutropenic Patients - This study is not yet open for patient recruitment (Current: 23 Nov 2006) - Fluconazole,Micafungin
• Impact of Heart Rate Characteristics Monitoring in Neonates - This study is currently recruiting patients (Current: 23 Nov 2006)
• Enteral Glutamine in Critical Illness - This study is not yet open for patient recruitment (Current: 23 Nov 2006) - Glutamine
• The AOT (Acridine Orange and Taurolidine) Trial - This study is not yet open for patient recruitment (Current: 23 Nov 2006) - taurolidine
• Super High-Flux - High Volume Dialysis in Sepsis-Induced Acute Renal Failure - This study is currently recruiting patients (Current: 23 Nov 2006)
• The Effects of HIV Protease Inhibitors in Severe Sepsis - This study has been completed (Current: 23 Nov 2006) - Nelfinavir
• Therapeutic Zinc in Infant Bacterial Illness - This study is currently recruiting patients (Current: 23 Nov 2006) - Drug: Zinc (zinc sulphate)
• Antibody Secreting Cell and Cyotkine Profiles in Neonates on ECMO - This study is not yet open for patient recruitment (Current: 23 Nov 2006)
• To Evaluate the Treatment Effect of an Anti-Infective Agent for Complicated Infections - This study is currently recruiting patients (Current: 23 Nov 2006) - MK0826, ertapenem sodium / Duration of Treatment: 14 Days
• Immunoadsorption of LPS, C5a and IL-6 in Severe Sepsis and Septic Shock (ISASS-1) - This study has been completed (Current: 23 Nov 2006)
• Near Infrared Spectroscopy (NIRS) in Severe Sepsis - This study is currently recruiting patients (Current: 23 Nov 2006)
• ACCESS: A Controlled Comparison of Eritoran Tetrasodium and Placebo in Patients With Severe Sepsis - This study is currently recruiting patients (Current: 23 Nov 2006) - E5564
• Evaluate Impact to Protein C Levels With Changing Dose/Duration of Drotrecogin Alfa (Activated) Administered to Severe Sepsis Patients - This study is not yet open for patient recruitment (Current: 23 Nov 2006) - Drotrecogin alfa (activated)
• Pleconaril Enteroviral Sepsis Syndrome - This study has been suspended (Current: 23 Nov 2006) - Pleconaril (VP63843)
• Diagnostic Study of Adrenal Cortical Function in Children With Septic Shock - This study has been completed (Current: 23 Nov 2006) - corticotropin
• Levosimendan Versus Dobutamine in Shock Patients - This study is currently recruiting patients (Current: 23 Nov 2006) - Levosimendan,Dobutamine
• Prophylactic Intrapartum Antibiotics and Immunological Markers for Postpartum Morbidity in HIV Positive Women - This study has been completed (Current: 23 Nov 2006) - Intrapartum Cefoxitin (2g) vs. placebo
• The Procalcitonin And Survival Study - This study is currently recruiting patients (Current: 23 Nov 2006)
• Mediators of Inflammation, Prognostic Markers and Genetic Polymorphisms in Patients With Sepsis - This study is currently recruiting patients (Current: 23 Nov 2006)
• Safety and Efficacy of PHP in the Treatment of Shock Associated With Systemic Inflammatory Response Syndrome (SIRS) - This study is no longer recruiting patients (Current: 23 Nov 2006) - pyridoxalated hemoglobin polyoxyethylene conjugate (PHP)
• Cleansing of Suction Blood in Cardiac Surgery for Reduced Inflammatory Response - This study is no longer recruiting patients (Current: 23 Nov 2006)
• Study of Sivelestat Sodium Hydrate in Acute Lung Injury (ALI) Associated With Systemic Inflammatory Response Syndrome (SIRS) in Japan - This study is currently recruiting patients (Current: 23 Nov 2006) - Sivelestat sodium hydrate
• Inflammatory Response During Anesthesia and Surgery. - This study is currently recruiting patients (Current: 23 Nov 2006)
• Ibuprofen in Sepsis Study - This study has been completed (Current: 23 Nov 2006) - ibuprofen
• Viral Load in Blood and Lymph Tissues of HIV-Infected Individuals - This study is currently recruiting patients (Current: 23 Nov 2006)
• An Open Label, Non-Comparative, Multicenter, Phase III Trial of the Efficacy, Safety and Toleration of Voriconazole in the Primary or Secondary Treatment of Invasive Fungal Infections - This study has been completed (Current: 23 Nov 2006)
• Comparing the Effectiveness of Fluconazole and a New Medicine (FK463) in Preventing Fungal Infections in Bone Marrow Transplant Patients - This study has been completed (Current: 23 Nov 2006)
• Antibiotic Treatment for Patients With Infections of Short Term In-Dwelling Vascular Catheters Due to a Specific Bacteria (Gram Positive Bacteria) - This study has been completed (Current: 23 Nov 2006) - Antibiotic,Vancomycin,Oxacillin,Dicloxacillin
• Safety and Efficacy of Dalbavancin Versus Vancomycin in the Treatment of Catheter-Related Bloodstream Infections - This study is no longer recruiting patients (Current: 23 Nov 2006) - dalbavancin
• Daptomycin in the Treatment of Subjects With Infective Endocarditis or Bacteremia Due to S. Aureus - This study has been completed (Current: 23 Nov 2006) - daptomycin
• Linezolid in the Treatment of Hemodialysis Patients With Catheter-Related Gram-Positive Bloodstream Infections - This study is currently recruiting patients (Current: 23 Nov 2006) - Cefazolin IV,Linezolid IV,Vancomycin (IV)
• Patient Plasma Response and Outcome in Septic Shock With Thrombocytopenia Associated Multiple Organ Failure in Children - This study is currently recruiting patients (Current: 23 Nov 2006)
• Alcohol Locks for the Prevention of Tunneled Catheter-Related Infections - This study is currently recruiting patients (Current: 23 Nov 2006)
• Dopexamine and Norepinephrine Compared With Epinephrine Alone in Septic Shock - This study has been completed (Current: 23 Nov 2006) - Dopexamine and norepinephrine,Epinephrine
• Corticosteroid Therapy of Septic Shock Corticus - This study is no longer recruiting patients (Current: 23 Nov 2006) - hydrocortisone sodium succinate
• The Role of Synbiotics in Reducing Post-Operative Infections in Patients Undergoing Cardiac Surgery: A Pilot Study - This study is currently recruiting patients (Current: 23 Nov 2006) - Synbiotic 2000
• Pharmacodynamic Parameters of Two Different Doses of Cefepime - This study is currently recruiting patients (Current: 23 Nov 2006)
• Voriconazole as Prophylaxis for Liver Transplant Recipients - This study is currently recruiting patients (Current: 23 Nov 2006)
• Micafungin Versus Fluconazole in the Treatment of Invasive Candidiasis and Candidemia - This study is currently recruiting patients (Current: 23 Nov 2006) - Micafungin
• Dose of Norepinephrine and the Concentration of L-Lactate in the Rectum and Stomach in Patients With Septic Shock. - This study is currently recruiting patients (Current: 23 Nov 2006) - Changing dose of norepinephrine and blood pressure
• Lactic Acid in the Rectum and Life-Threatening Infection. - This study is not yet open for patient recruitment (Current: 23 Nov 2006)
• Colistin IV-Pilot Study: Pharmacokinetics and Pharmacodynamics of Intravenous Colistin - This study is currently recruiting patients (Current: 23 Nov 2006)
• Haemofiltration Study : IVOIRE (hIgh VOlume in Intensive Care) - This study is currently recruiting patients (Current: 23 Nov 2006)
• Yellow Fever Virus Vaccine and Immune Globulin Study - This study is not yet open for patient recruitment (Current: 23 Nov 2006)
• Prevention of Bacteremia Induced by Debridement of Pressure Ulcer - This study is currently recruiting patients (Current: 23 Nov 2006)
• Comparison of Vasopressin and Other Pressors in Septic Shock - This study has been completed (Current: 23 Nov 2006) - vasopressin
• Combination of Corticotherapy and Intensive Insulin Therapy for Septic Shock - This study is currently recruiting patients (Current: 23 Nov 2006) - insulin,hydrocortisone,fludrocortisone
• Early Albumin Resuscitation During Septic Shock - This study is not yet open for patient recruitment (Current: 23 Nov 2006) - interventional
• COMPACT - COMbining Plasma-Filtration and Adsorption Clinical Trial - This study is not yet open for patient recruitment (Current: 23 Nov 2006)
• Barrier Function and Production of Inflammatory Cytokines in the Rectal Mucosa in Patients With Septic Shock. - This study is not yet open for patient recruitment (Current: 23 Nov 2006)
• Reconstruction of Monocytic Immunocompetence by GM-CSF in Patients With Severe Sepsis and Septic Shock - This study is currently recruiting patients (Current: 23 Nov 2006) - GM-CSF (verum)
• Procalcitonin Increase Identifies Critically Ill Patients at High Risk of Mortality - This study has been completed (Current: 23 Nov 2006)
• Time Course of Procalcitonin and C Reactive Protein in Septic Patients Under Treatment With Corticosteroids - This study is currently recruiting patients (Current: 23 Nov 2006)
• Is Helicobacter Pylori Infection a Cause or Treatment Failure of Iron Deficiency Anemia in Children in Bangladesh? - This study has been completed (Current: 23 Nov 2006) - Iron
• Potent Antiviral Therapy for Critically Ill HIV Infected Patients Admitted to Intensive Care - This study has been completed (Current: 23 Nov 2006) - Lamivudine/Zidovudine,Nelfinavir mesylate,Efavirenz,Lamivudine,Zidovudine
• Early Diagnosis of Candida Infections in Premature Infants - This study is currently recruiting patients (Current: 23 Nov 2006)
• Albumin Administration in Patients With Cirrhosis and Infections Unrelated to Spontaneous Bacterial Peritonitis - This study is currently recruiting patients (Current: 23 Nov 2006) - Human Albumin
• Functional Genomic Influences on Disease Progression and Outcome in Sepsis - This study is currently recruiting patients (Current: 23 Nov 2006)
• Effect of Leukoreduced Blood Transfusions on Infection Following Trauma - This study has been completed (Current: 23 Nov 2006)
• Clinical Trial Comparing Safety and Pharmacokinetics of Standard Antibiotic Therapy, Plus Aurexis or Placebo, for Treatment of Staphylococcus Aureus Bacteremia (SAB) - This study has been completed (Current: 23 Nov 2006) - Aurexis®
• Use of in-Line Filtration in Critically Ill Children - This study is currently recruiting patients (Current: 23 Nov 2006)
• Efficacy Study of a Facemask Device to Treat Hypotension - This study is currently recruiting patients (Current: 23 Nov 2006)
• Efficacy and Safety of Colloids Versus Crystalloids for Fluid Resuscitation in Critically Ill Patients - This study is currently recruiting patients (Current: 23 Nov 2006) - Crystalloids,Colloids
• Cerebral Blood Flow and Metabolism During Hypoxia and Endotoxemia - This study is currently recruiting patients (Current: 23 Nov 2006)
• Safety and Efficacy Study of Intentional Delivery in Women With Preterm and Prelabour Rupture of the Membranes - This study is currently recruiting patients (Current: 23 Nov 2006)

Drugs used in Clinical Trials for Sepsis

The format for each of the following is:

• The drug,
• followed by the name of the trial,
• followed by whether the trial is recruiting patients,
  - The trial may not have started and not yet recruiting, or the trial may have started and do not need any more recruitements, or the trial may be completed.
  - Note**: Please follow the link to determine the current trial status.

ClinicalTrials.gov has listed the following drugs in trials for Sepsis:

• 10% Hemohes® (10% Hydroxyethyl starch) - Efficacy of Volume Substitution and Insulin Therapy in Severe Sepsis (VISEP Trial) - This study has been completed (Current: 23 Nov 2006)
• 2% chlorhexidine gluconate impregnated cloth - Skin Cleansing With Chlorhexidine to Decrease Hospital Acquired Infections - This study is currently recruiting patients (Current: 23 Nov 2006)
• Actrapid® (Insulin) - Efficacy of Volume Substitution and Insulin Therapy in Severe Sepsis (VISEP Trial) - This study has been completed (Current: 23 Nov 2006)
• Antibiotic - Antibiotic Treatment for Patients With Infections of Short Term In-Dwelling Vascular Catheters Due to a Specific Bacteria (Gram Positive Bacteria) - This study has been completed (Current: 23 Nov 2006)
• Antioxidants - Trial of Glutamine and Antioxidant Supplementation in Critically Ill Patients - This study is currently recruiting patients (Current: 23 Nov 2006)
• Aurexis® - Clinical Trial Comparing Safety and Pharmacokinetics of Standard Antibiotic Therapy, Plus Aurexis or Placebo, for Treatment of Staphylococcus Aureus Bacteremia (SAB) - This study has been completed (Current: 23 Nov 2006)
• Cefazolin IV - Linezolid in the Treatment of Hemodialysis Patients With Catheter-Related Gram-Positive Bloodstream Infections - This study is currently recruiting patients (Current: 23 Nov 2006)
• Ceftrioxone, Procaine Penicillin And Gentamicin, Oral Cotrimoxazole And Gentamicin - Efficacy Study of Community-Based Treatment of Serious Bacterial Infections in Young Infants - This study is currently recruiting patients (Current: 23 Nov 2006)
• Changing dose of norepinephrine and blood pressure - Dose of Norepinephrine and the Concentration of L-Lactate in the Rectum and Stomach in Patients With Septic Shock. - This study is currently recruiting patients (Current: 23 Nov 2006)
• Chlorhexidine - Prevention of Perinatal Sepsis (PoPS): Evaluation of Chlorhexidine Wipes of Birth Canal and Newborn - This study is currently recruiting patients (Current: 23 Nov 2006)
• Colloids - Efficacy and Safety of Colloids Versus Crystalloids for Fluid Resuscitation in Critically Ill Patients - This study is currently recruiting patients (Current: 23 Nov 2006)
• Corticotropin - Diagnostic Study of Adrenal Cortical Function in Children With Septic Shock - This study has been completed (Current: 23 Nov 2006)
• Crystalloids - Efficacy and Safety of Colloids Versus Crystalloids for Fluid Resuscitation in Critically Ill Patients - This study is currently recruiting patients (Current: 23 Nov 2006)
• Dalbavancin - Safety and Efficacy of Dalbavancin Versus Vancomycin in the Treatment of Catheter-Related Bloodstream Infections - This study is no longer recruiting patients (Current: 23 Nov 2006)
• Daptomycin - Daptomycin in the Treatment of Subjects With Infective Endocarditis or Bacteremia Due to S. Aureus - This study has been completed (Current: 23 Nov 2006)
• Defined percentage of omega-3-fatty acids - The Benefit of Adding Fish Oil to the Nutrition of Critically Ill Patients - This study is currently recruiting patients (Current: 23 Nov 2006)
• Dicloxacillin - Antibiotic Treatment for Patients With Infections of Short Term In-Dwelling Vascular Catheters Due to a Specific Bacteria (Gram Positive Bacteria) - This study has been completed (Current: 23 Nov 2006)
• Dobutamine - Levosimendan Versus Dobutamine in Shock Patients - This study is currently recruiting patients (Current: 23 Nov 2006)
• Dopexamine and norepinephrine - Dopexamine and Norepinephrine Compared With Epinephrine Alone in Septic Shock - This study has been completed (Current: 23 Nov 2006)
• Drotrecogin Alfa (Activated) - A Trial of Heparin in Patients With Severe Sepsis Who Are Undergoing Treatment With Drotrecogin Alfa (Activated) - This study has been completed (Current: 23 Nov 2006)
• Drotrecogin Alfa (Activated) - Extended Therapy of Drotrecogin Alfa (Activated) 4 vs 7 Days Infusion - This study is currently recruiting patients (Current: 23 Nov 2006)
• Drotrecogin Alfa (Activated) - Hemodynamic and Perfusion Response to Drotrecogin Alfa (Activated) in Patients With Septic Shock - This study is currently recruiting patients (Current: 23 Nov 2006)
• Drotrecogin alfa (activated)(recombinant human Activated Protein C) - Investigation of the Efficacy and Safety of Drotrecogin Alfa (Activated) in Pediatric Severe Sepsis - This study has been completed (Current: 23 Nov 2006)
• Drotrecogin alfa (activated) - Evaluate Impact to Protein C Levels With Changing Dose/Duration of Drotrecogin Alfa (Activated) Administered to Severe Sepsis Patients - This study is not yet open for patient recruitment (Current: 23 Nov 2006)
• Drotrecogin alfa (activated) - The Study of Drotrecogin Alfa (Activated) in a Subpopulation of Adult Patients With Severe Sepsis - This study has been completed (Current: 23 Nov 2006)
• Drug: Zinc (zinc sulphate) - Therapeutic Zinc in Infant Bacterial Illness - This study is currently recruiting patients (Current: 23 Nov 2006)
• E. Coli endotoxin - Low-Dose Endotoxemia and the Acute Phase Response - This study is no longer recruiting patients (Current: 23 Nov 2006)
• E5564 - A Safety and Efficacy Study of Intravenous E5564 in Patients With Severe Sepsis - This study has been completed (Current: 23 Nov 2006)
• E5564 - ACCESS: A Controlled Comparison of Eritoran Tetrasodium and Placebo in Patients With Severe Sepsis - This study is currently recruiting patients (Current: 23 Nov 2006)
• Efavirenz - Potent Antiviral Therapy for Critically Ill HIV Infected Patients Admitted to Intensive Care - This study has been completed (Current: 23 Nov 2006)
• Eicosapenaenoic acid (EPA), Gamma-Linolenic Acid (GLA) and Antioxidants (Study Group) - The Effects of EPA, GLA and Antioxidants in the Treatment of Sepsis - This study is not yet open for patient recruitment (Current: 23 Nov 2006)
• Empirical Vancomycin - Trial of Prophylactic Versus Empirical Vancomycin for the Prevention of Streptococcal Sepsis After Hematopoietic Cell Transplantation - This study has been completed (Current: 23 Nov 2006)
• Epinephrine - Dopexamine and Norepinephrine Compared With Epinephrine Alone in Septic Shock - This study has been completed (Current: 23 Nov 2006)
• Fluconazole - Fluconazole Versus Micafungin for Candida Bloodstream Infection in Non-Neutropenic Patients - This study is not yet open for patient recruitment (Current: 23 Nov 2006)
• Fludrocortisone - Combination of Corticotherapy and Intensive Insulin Therapy for Septic Shock - This study is currently recruiting patients (Current: 23 Nov 2006)
• Fludrocortisone - Hydrocortisone Versus Hydrocortisone Plus Fludrocortisone for the Treatment of Adrenal Insufficiency in Severe Sepsis - This study is currently recruiting patients (Current: 23 Nov 2006)
• GM-CSF (verum) - Reconstruction of Monocytic Immunocompetence by GM-CSF in Patients With Severe Sepsis and Septic Shock - This study is currently recruiting patients (Current: 23 Nov 2006)
• Glutamine - CRISIS Prevention Study - This study is not yet open for patient recruitment (Current: 23 Nov 2006)
• Glutamine - Enteral Glutamine in Critical Illness - This study is not yet open for patient recruitment (Current: 23 Nov 2006)
• Glutamine - Glutamine Supplementation to Prevent Death or Infection in Extremely Premature Infants - This study has been completed (Current: 23 Nov 2006)
• Glutamine - Trial of Glutamine and Antioxidant Supplementation in Critically Ill Patients - This study is currently recruiting patients (Current: 23 Nov 2006)
• Human Albumin - Albumin Administration in Patients With Cirrhosis and Infections Unrelated to Spontaneous Bacterial Peritonitis - This study is currently recruiting patients (Current: 23 Nov 2006)
• Hydrocortisone Administration (Standard of Care Therapy) - Impact of Hydrocortisone Administration on White Blood Cell Gene Expression in Patients With Severe Sepsis - This study is currently recruiting patients (Current: 23 Nov 2006)
• Hydrocortisone Sodium Succinate - Corticosteroid Therapy of Septic Shock Corticus - This study is no longer recruiting patients (Current: 23 Nov 2006)
• Hydrocortisone - Combination of Corticotherapy and Intensive Insulin Therapy for Septic Shock - This study is currently recruiting patients (Current: 23 Nov 2006)
• Hydroxy-Ethyl Starch (Mw 130; 0.4) Vs. Normal Saline - BaSES Trial: Basel Starch Evaluation in Sepsis - This study is currently recruiting patients (Current: 23 Nov 2006)
• Ibuprofen - Ibuprofen in Sepsis Study - This study has been completed (Current: 23 Nov 2006)
• Inhaled Nitric Oxide - Effects of Endotoxin in Normal Human Volunteers - This study is no longer recruiting patients (Current: 23 Nov 2006)
• Inhaled Nitric Oxide - Study of Inhaled Nitric Oxide for Preterm Infants - This study is no longer recruiting patients (Current: 23 Nov 2006)
• Insulin - Combination of Corticotherapy and Intensive Insulin Therapy for Septic Shock - This study is currently recruiting patients (Current: 23 Nov 2006)
• Interventional - Early Albumin Resuscitation During Septic Shock - This study is not yet open for patient recruitment (Current: 23 Nov 2006)
• Intrapartum Cefoxitin (2g) vs. placebo - Prophylactic Intrapartum Antibiotics and Immunological Markers for Postpartum Morbidity in HIV Positive Women - This study has been completed (Current: 23 Nov 2006)
• Intravenous Clarithromycin - Intravenous Clarithromycin in Septic Syndrome - This study has been completed (Current: 23 Nov 2006)
• Intravenous GR270773 - Phospholipid emulsion - A Study To Compare The Effects Of The Infusion Of A Sepsis Drug Between Healthy Adults And Adults With Damaged Livers - This study is currently recruiting patients (Current: 23 Nov 2006)
• Intravenous GR270773- Phospholipid Emulsion - GR270773 In The Treatment Of Suspected Or Confirmed Gram-Negative Severe Sepsis In Adults - This study is no longer recruiting patients (Current: 23 Nov 2006)
• Intravenous hydrocortisone - Cortisol Control of Human Inflammatory Responses to Endotoxin - This study is currently recruiting patients (Current: 23 Nov 2006)
• Iron - Is Helicobacter Pylori Infection a Cause or Treatment Failure of Iron Deficiency Anemia in Children in Bangladesh? - This study has been completed (Current: 23 Nov 2006)
• Lactobacillus rhamnosus GR1 and Lactobacillus reuteri RC-14 - Probiotics for the Prevention of Premature Birth and Neonatal Related Morbidity - This study is currently recruiting patients (Current: 23 Nov 2006)
• Lamivudine/Zidovudine - Potent Antiviral Therapy for Critically Ill HIV Infected Patients Admitted to Intensive Care - This study has been completed (Current: 23 Nov 2006)
• Lamivudine - Potent Antiviral Therapy for Critically Ill HIV Infected Patients Admitted to Intensive Care - This study has been completed (Current: 23 Nov 2006)
• Levosimendan - Levosimendan Versus Dobutamine in Shock Patients - This study is currently recruiting patients (Current: 23 Nov 2006)
• Linezolid IV - Linezolid in the Treatment of Hemodialysis Patients With Catheter-Related Gram-Positive Bloodstream Infections - This study is currently recruiting patients (Current: 23 Nov 2006)
• Low molecular weight heparin - A Trial of Heparin in Patients With Severe Sepsis Who Are Undergoing Treatment With Drotrecogin Alfa (Activated) - This study has been completed (Current: 23 Nov 2006)
• MBI 226 - Safety and Efficacy of MBI 226 for the Prevention of Central Venous Catheter-Related Bloodstream Infections - This study has been completed (Current: 23 Nov 2006)
• MK0826, ertapenem sodium / Duration of Treatment: 14 Days - To Evaluate the Treatment Effect of an Anti-Infective Agent for Complicated Infections - This study is currently recruiting patients (Current: 23 Nov 2006)
• Meropenem - Pharmacoeconomic Analysis of First Line Meropenem Versus Standard Antibiotic Treatment in Seriously Infected Secondary Nosocomial Sepsis Syndrome Patients. - This study is currently recruiting patients (Current: 23 Nov 2006)
• Methylene Blue, Inhaled Nitric Oxide - Studies of Acute Lung Injury (ALI) and Acute Respiratory Distress Syndrome - This study is currently recruiting patients (Current: 23 Nov 2006)
• Metoclopramide - CRISIS Prevention Study - This study is not yet open for patient recruitment (Current: 23 Nov 2006)
• Micafungin - Fluconazole Versus Micafungin for Candida Bloodstream Infection in Non-Neutropenic Patients - This study is not yet open for patient recruitment (Current: 23 Nov 2006)
• Micafungin - Micafungin Versus Fluconazole in the Treatment of Invasive Candidiasis and Candidemia - This study is currently recruiting patients (Current: 23 Nov 2006)
• Nelfinavir mesylate - Potent Antiviral Therapy for Critically Ill HIV Infected Patients Admitted to Intensive Care - This study has been completed (Current: 23 Nov 2006)
• Nelfinavir - The Effects of HIV Protease Inhibitors in Severe Sepsis - This study has been completed (Current: 23 Nov 2006)
• Norepinephrine plus Dobutamine vs Epinephrine - Norepinephrine Plus Dobutamine Versus Epinephrine Alone for the Management of Septic Shock - This study has been completed (Current: 23 Nov 2006)
• Novolin R (human recombinant Insulin) - The Effect of Intensive Insulin Therapy in the Surgical Critical Care Unit - This study has been completed (Current: 23 Nov 2006)
• Oxacillin - Antibiotic Treatment for Patients With Infections of Short Term In-Dwelling Vascular Catheters Due to a Specific Bacteria (Gram Positive Bacteria) - This study has been completed (Current: 23 Nov 2006)
• Oxytocin - Oxytocin Effects on Cytokines and Endocrine Parameters After LPS Induced Systemic Inflammatory Effects in Healthy Volunteers - This study is currently recruiting patients (Current: 23 Nov 2006)
• Parenteral cysteine-HCl supplementation - Cysteine Supplementation in Critically Ill Neonates - This study is not yet open for patient recruitment (Current: 23 Nov 2006)
• Placebo - Extended Therapy of Drotrecogin Alfa (Activated) 4 vs 7 Days Infusion - This study is currently recruiting patients (Current: 23 Nov 2006)
• Placebo - Hemodynamic and Perfusion Response to Drotrecogin Alfa (Activated) in Patients With Septic Shock - This study is currently recruiting patients (Current: 23 Nov 2006)
• Pleconaril (VP63843) - Pleconaril Enteroviral Sepsis Syndrome - This study has been suspended (Current: 23 Nov 2006)
• Prophylactic Vancomycin - Trial of Prophylactic Versus Empirical Vancomycin for the Prevention of Streptococcal Sepsis After Hematopoietic Cell Transplantation - This study has been completed (Current: 23 Nov 2006)
• Pyridoxalated Hemoglobin Polyoxyethylene Conjugate (Php) - Safety and Efficacy of PHP in the Treatment of Shock Associated With Systemic Inflammatory Response Syndrome (SIRS) - This study is no longer recruiting patients (Current: 23 Nov 2006)
• Recombinant Chimeric Monoclonal Antibody - A Safety and Efficacy Study of Hospitalized Patients With Community-Acquired Pneumonia and Sepsis - This study has been completed (Current: 23 Nov 2006)
• Reference Endotoxin - Effects of Endotoxin in Normal Human Volunteers - This study is no longer recruiting patients (Current: 23 Nov 2006)
• Rosuvastatin - Effect of Rosuvastatin in Abdominal Sepsis - This study is currently recruiting patients (Current: 23 Nov 2006)
• Rpaf-Ah - Safety and Efficacy of Recombinant Human Platelet-Activating Factor Acetylhydrolase for the Treatment of Severe Sepsis - This study has been terminated (Current: 23 Nov 2006)
• Selenium as sodium selenite - Selenium, as Sodium Selenite, in the Treatment of Septic Shock - This study has been completed (Current: 23 Nov 2006)
• Selenium - CRISIS Prevention Study - This study is not yet open for patient recruitment (Current: 23 Nov 2006)
• Sivelestat sodium hydrate - Study of Sivelestat Sodium Hydrate in Acute Lung Injury (ALI) Associated With Systemic Inflammatory Response Syndrome (SIRS) in Japan - This study is currently recruiting patients (Current: 23 Nov 2006)
• Spla2 Inhibitor - A Phase IIb Study to Determine the Efficacy and Safety of the Study Drug in Patients With Severe Sepsis - This study has been completed (Current: 23 Nov 2006)
• Sterofundin® (Ringer lactate solution) - Efficacy of Volume Substitution and Insulin Therapy in Severe Sepsis (VISEP Trial) - This study has been completed (Current: 23 Nov 2006)
• Synbiotic 2000 - The Role of Synbiotics in Reducing Post-Operative Infections in Patients Undergoing Cardiac Surgery: A Pilot Study - This study is currently recruiting patients (Current: 23 Nov 2006)
• TAK-242 - Multicenter, Double-Blind, Placebo-Controlled Study To Evaluate Efficacy & Safety Of TAK-242 In Adults With Severe Sepsis - This study is currently recruiting patients (Current: 23 Nov 2006)
• Taurolidine - The AOT (Acridine Orange and Taurolidine) Trial - This study is not yet open for patient recruitment (Current: 23 Nov 2006)
• Unfractionated heparin - A Trial of Heparin in Patients With Severe Sepsis Who Are Undergoing Treatment With Drotrecogin Alfa (Activated) - This study has been completed (Current: 23 Nov 2006)
• Unfractioned Heparin - Unfractioned Heparin for Treatment of Sepsis - This study is currently recruiting patients (Current: 23 Nov 2006)
• Vancomycin (IV) - Linezolid in the Treatment of Hemodialysis Patients With Catheter-Related Gram-Positive Bloodstream Infections - This study is currently recruiting patients (Current: 23 Nov 2006)
• Vancomycin - Antibiotic Treatment for Patients With Infections of Short Term In-Dwelling Vascular Catheters Due to a Specific Bacteria (Gram Positive Bacteria) - This study has been completed (Current: 23 Nov 2006)
• Vasoactive Intestinal Peptide - Phase I Study of Vasoactive Intestinal Peptide in Patients With Acute Respiratory Distress Syndrome and Sepsis - This study is currently recruiting patients (Current: 23 Nov 2006)
• Vasopressin - Comparison of Vasopressin and Other Pressors in Septic Shock - This study has been completed (Current: 23 Nov 2006)
• Veronate - Safety and Efficacy of Veronate Versus Placebo in Preventing Nosocomial Staphylococcal Sepsis in Premature Infants - This study is no longer recruiting patients (Current: 23 Nov 2006)
• Xigris - A Safety Evaluation of Xigris in Patients With Blood Cancer Who Develop Severe Infection Related to Bone Marrow Transplantation - This study has been completed (Current: 23 Nov 2006)
• Zidovudine - Potent Antiviral Therapy for Critically Ill HIV Infected Patients Admitted to Intensive Care - This study has been completed (Current: 23 Nov 2006)
• Zinc - CRISIS Prevention Study - This study is not yet open for patient recruitment (Current: 23 Nov 2006)

The trial data on this page has been sourced from

• The U.S. National Library of Medicine (NLM) together with ClinicalTrials.gov

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