Clinical Trials for Polyneuropathy

Clinical trials are research studies conducted in an effort to improve overall patient health and care. Each trial involves running supervised tests to determine the effectiveness and safety of new drugs, procedures and/or devices with the aim of answering scientific questions about a disease or condition. Risks and side-effects are also evaluated during these trials with results ranging from being unpleasant, with side effects such as headaches, to more serious or even life-threatening risks. A clinical trial may be separated into phases, or steps, with each step designed to answer a separate research question. This maybe reflected in the trial name.

A brief description of each phase:

• Phase I: Usually designed to evaluate safety, determine a safe dosage range, and identify side effects on a small group of patients.
• Phase II: If Phase I is successful, the trial is then repeated with a larger group to further evaluate its effect and safety.
• Phase III: Trials are conducted on an ever larger group and are compared with the best current treatment while gathering more information on effect and safety.
• Phase IV: These studies monitor long-term side effects after the treatment has been marketed.

Clinical Trials data for Polyneuropathy is grouped into the following categories:-

• View by trial name
• View by drugs used in Polyneuropathy clinical trials

Clinical Trials by trial name

The format for each of the following is:

• The name of the trial,
• followed by whether the trial is recruiting patients,
  - The trial may not have started and not yet recruiting, or the trial may have started and do not need any more recruitements, or the trial may be completed.
  - Note**: Please follow the link to determine the current trial status.
• followed by a list of drug/s, if any, used in the trial

ClinicalTrials.gov has listed the following trials for Polyneuropathy:

• Tolerability of Three Local Anesthetic Formulations in Conjunction With NGX-4010 for the Treatment of Neuropathic Pain - This study is no longer recruiting patients (Current: 23 Nov 2006) - Capsaicin Dermal Patch
• An Open-Label Extension Study of NGX-4010 for the Treatment of Neuropathic Pain - This study has been terminated (Current: 23 Nov 2006) - Capsaicin Dermal Patch
• Escitalopram as a Treatment for Pain in Polyneuropathy - This study is currently recruiting patients (Current: 23 Nov 2006) - escitalopram
• A Study To Evaluate The Effect Of Topiramate On Clinical And Electrophysiological Parameters In Subjects With Diabetic Peripheral Polyneuropathy. - This study is no longer recruiting patients (Current: 23 Nov 2006) - topiramate
• Rituximab to Treat Neuropathy With Anti-MAG Antibodies - This study is no longer recruiting patients (Current: 23 Nov 2006) - Rituximab
• Hematopoietic Stem Cell Support in Chronic Inflammatory Demyelinating Polyneuropathy - This study is currently recruiting patients (Current: 23 Nov 2006)
• Levetiracetam for Painful Polyneuropathy - This study is currently recruiting patients (Current: 23 Nov 2006) - levetiracetam
• A Study to Determine If Levetiracetam Will Assist Those Suffering From Chronic Idiopathic Axonal Polyneuropathy. - This study is currently recruiting patients (Current: 23 Nov 2006) - levetiracetam
• Efficacy and Safety of Levetiracetam in Adults With CIAP - This study is currently recruiting patients (Current: 23 Nov 2006) - levetiracetam
• Lidorestat (IDD 676) for the Treatment of Diabetic Neuropathy - This study is no longer recruiting patients (Current: 23 Nov 2006) - Lidorestat (IDD 676)
• The Significance of Glucose Intolerance in the Pathogenesis of Idiopathic Axonal Polyneuropathy - This study is no longer recruiting patients (Current: 23 Nov 2006)
• The Effect of Diflunisal on Familial Amyloidosis - This study is currently recruiting patients (Current: 23 Nov 2006) - diflunisal
• RIMAG Study: Trial of Rituximab Versus Placebo in Polyneuropathy Associated With Anti-MAG IgM Monoclonal Gammopathy - This study is not yet open for patient recruitment (Current: 23 Nov 2006) - Rituximab
• Dermal Thermometry and Self-Care of High Risk Diabetic Patients - This study is no longer recruiting patients (Current: 23 Nov 2006)
• TAK-128 Effects on Diabetic Peripheral Neuropathy - This study is currently recruiting patients (Current: 23 Nov 2006) - TAK-128
• Effect of C-Peptide on Diabetic Peripheral Neuropathy - This study has been completed (Current: 23 Nov 2006) - C-peptide
• TempTouch IR Thermometry & Diabetic Patient Self-Care - This study has been completed (Current: 23 Nov 2006)
• Safety and Efficacy of MCC-257 in the Treatment of Diabetic Polyneuropathy - This study is currently recruiting patients (Current: 23 Nov 2006) - MCC-257
• Assessment of Efficacy and Safety of Thioctic Acid in the Oral Treatment of Symptomatic Diabetic Neuropathy (SYDNEY 2) - This study has been completed (Current: 23 Nov 2006) - Thioctic Acid
• A Phase I/II Pilot Treatment Study Of CSF Penetration And Response To Ganciclovir And Foscarnet In CMV Neurologic Disease. - This study has been terminated (Current: 23 Nov 2006) - Foscarnet sodium,Ganciclovir
• Phase III Multicenter Double Blind Controlled Trial of Human Immune Globulin Therapy in Previously Untreated Patients With Chronic Inflammatory Demyelinating Neuropathy - This study has been completed (Current: 23 Nov 2006) - immune globulin
• Phase III Randomized, Double-Blind, Placebo-Controlled Study of Intravenous Immune Globulin for Chronic Inflammatory Demyelinating Polyneuropathy - This study has been completed (Current: 23 Nov 2006) - Immune globulin
• Randomized Study of Plasmapheresis or Human Immunoglobulin Infusion in Childhood Guillain-Barre Syndrome - This study has been suspended (Current: 23 Nov 2006) - Immune globulin
• Phase III Randomized, Double-Blind, Placebo-Controlled Study of 3,4-Diaminopyridine for Demyelinating Polyneuropathy - This study has been completed (Current: 23 Nov 2006) - ,4-diaminopyridine
• Quantitative Genetic Analysis of Lipid Research Clinic Family Data - This study has been completed (Current: 23 Nov 2006)
• Pain Treatment for Sciatica - This study is no longer recruiting patients (Current: 23 Nov 2006) - Nortriptyline,Morphine
• Nuclear Magnetic Spectroscopy Imaging to Evaluate Primary Lateral Sclerosis, Hereditary Spastic Paraplegia and Amyotrophic Lateral Sclerosis - This study has been completed (Current: 23 Nov 2006)
• Assessment of Chronic Guillain-Barre Syndrome Improvement With Use of 4-Aminopyridine - This study has been completed (Current: 23 Nov 2006) - 4-aminopyridine (4-AP)
• Safety and Efficacy of Avonex in Subjects With Chronic Inflammatory Demyelinating Polyradiculoneuropathy (CIDP) - This study is no longer recruiting patients (Current: 23 Nov 2006) - Interferon Beta-1a
• Study of REN-1654 in Patients With Sciatica Pain - This study is no longer recruiting patients (Current: 23 Nov 2006) - REN-1654
• Study to Evaluate the Efficacy and Safety of Lenalidomide in the Treatment of Painful Lumbar Radiculopathy - This study is currently recruiting patients (Current: 23 Nov 2006) - Lenalidomide (CC-5013)
• Westeinde Brachialgia Study - This study is currently recruiting patients (Current: 23 Nov 2006)
• Follow up and Observation of Charcot Marie Tooth Disease in Families - This study has been completed (Current: 23 Nov 2006)
• Trial of Efficacy and Safety of Pregabalin in Subjects With Neuropathic Pain Associated With Lumbo-Sacral Radiculopathy - This study is currently recruiting patients (Current: 23 Nov 2006) - pregabalin
• Early Mechanical Ventilation for Guillain Barr Syndrome - This study is currently recruiting patients (Current: 23 Nov 2006)
• The Changes of Cytokines in Guillain Barr Syndrome: the Correlation With Clinical Manifestations and Skin Innervation - This study is currently recruiting patients (Current: 23 Nov 2006)
• Immune Globulin Intravenous (IGIV) For Chronic Inflammatory Demyelinating Polyneuropathy (CIDP) - This study is no longer recruiting patients (Current: 23 Nov 2006) - Immune Globulin Intravenous (Human)
• Ascorbic Acid Treatment in CMT1A Trial (AATIC) - This study is currently recruiting patients (Current: 23 Nov 2006) - Ascorbic Acid
• Study of CIDP Patients During IVIG Treatment - This study is currently recruiting patients (Current: 23 Nov 2006) - intravenous gammaglobulin
• Oral Dexamethasone for the Treatment of Cervical Radiculopathy - This study is not yet open for patient recruitment (Current: 23 Nov 2006) - Dexamethasone
• Safety Study of Preservon-Treated Bone Implants for Cervical Fusion in the Treatment of Cervical Radiculopathy or Myelopathy - This study is currently recruiting patients (Current: 23 Nov 2006)
• Efficacy of Epidural Etanercept in the Treatment of Radicular Low Back Pain (LBP). This is the Main Research Project Involved in This Grant. - This study is currently recruiting patients (Current: 23 Nov 2006) - epidural injection of etanercept
• Nerve Damage in Patients With HIV Infection Who Have Been Treated With Anti-HIV Drugs - This study is no longer recruiting patients (Current: 23 Nov 2006)
• Effects of Pregabalin on Mechanical Hyperalgesia - This study is not yet open for patient recruitment (Current: 23 Nov 2006) - Pregabalin
• Safety and Efficacy of AS-3201 in the Treatment of Diabetic Sensorimotor Polyneuropathy - This study is no longer recruiting patients (Current: 23 Nov 2006) - ranirestat, (AS-3201)
• New Onset Weakness in Critically Ill Patients and the Risk of Death and Recurrent ICU Admission - This study is currently recruiting patients (Current: 23 Nov 2006)
• Study of NGX-4010 for the Treatment of Painful HIV-Associated Neuropathy - This study is currently recruiting patients (Current: 23 Nov 2006) - Capsaicin Dermal Patch
• Intravenous Immunoglobulin (IVIg) for the Treatment of Chronic Inflammatory Demyelinating Polyneuropathy (CIDP) - This study has been completed (Current: 23 Nov 2006)

Drugs used in Clinical Trials for Polyneuropathy

The format for each of the following is:

• The drug,
• followed by the name of the trial,
• followed by whether the trial is recruiting patients,
  - The trial may not have started and not yet recruiting, or the trial may have started and do not need any more recruitements, or the trial may be completed.
  - Note**: Please follow the link to determine the current trial status.

ClinicalTrials.gov has listed the following drugs in trials for Polyneuropathy:

• ,4-diaminopyridine - Phase III Randomized, Double-Blind, Placebo-Controlled Study of 3,4-Diaminopyridine for Demyelinating Polyneuropathy - This study has been completed (Current: 23 Nov 2006)
• 4-aminopyridine (4-AP) - Assessment of Chronic Guillain-Barre Syndrome Improvement With Use of 4-Aminopyridine - This study has been completed (Current: 23 Nov 2006)
• Ascorbic Acid - Ascorbic Acid Treatment in CMT1A Trial (AATIC) - This study is currently recruiting patients (Current: 23 Nov 2006)
• C-peptide - Effect of C-Peptide on Diabetic Peripheral Neuropathy - This study has been completed (Current: 23 Nov 2006)
• Capsaicin Dermal Patch - An Open-Label Extension Study of NGX-4010 for the Treatment of Neuropathic Pain - This study has been terminated (Current: 23 Nov 2006)
• Capsaicin Dermal Patch - Study of NGX-4010 for the Treatment of Painful HIV-Associated Neuropathy - This study is currently recruiting patients (Current: 23 Nov 2006)
• Capsaicin Dermal Patch - Tolerability of Three Local Anesthetic Formulations in Conjunction With NGX-4010 for the Treatment of Neuropathic Pain - This study is no longer recruiting patients (Current: 23 Nov 2006)
• Dexamethasone - Oral Dexamethasone for the Treatment of Cervical Radiculopathy - This study is not yet open for patient recruitment (Current: 23 Nov 2006)
• Diflunisal - The Effect of Diflunisal on Familial Amyloidosis - This study is currently recruiting patients (Current: 23 Nov 2006)
• Epidural Injection Of Etanercept - Efficacy of Epidural Etanercept in the Treatment of Radicular Low Back Pain (LBP). This is the Main Research Project Involved in This Grant. - This study is currently recruiting patients (Current: 23 Nov 2006)
• Escitalopram - Escitalopram as a Treatment for Pain in Polyneuropathy - This study is currently recruiting patients (Current: 23 Nov 2006)
• Foscarnet sodium - A Phase I/II Pilot Treatment Study Of CSF Penetration And Response To Ganciclovir And Foscarnet In CMV Neurologic Disease. - This study has been terminated (Current: 23 Nov 2006)
• Ganciclovir - A Phase I/II Pilot Treatment Study Of CSF Penetration And Response To Ganciclovir And Foscarnet In CMV Neurologic Disease. - This study has been terminated (Current: 23 Nov 2006)
• Immune Globulin Intravenous (Human) - Immune Globulin Intravenous (IGIV) For Chronic Inflammatory Demyelinating Polyneuropathy (CIDP) - This study is no longer recruiting patients (Current: 23 Nov 2006)
• Immune Globulin - Phase III Multicenter Double Blind Controlled Trial of Human Immune Globulin Therapy in Previously Untreated Patients With Chronic Inflammatory Demyelinating Neuropathy - This study has been completed (Current: 23 Nov 2006)
• Immune globulin - Phase III Randomized, Double-Blind, Placebo-Controlled Study of Intravenous Immune Globulin for Chronic Inflammatory Demyelinating Polyneuropathy - This study has been completed (Current: 23 Nov 2006)
• Immune globulin - Randomized Study of Plasmapheresis or Human Immunoglobulin Infusion in Childhood Guillain-Barre Syndrome - This study has been suspended (Current: 23 Nov 2006)
• Interferon Beta-1a - Safety and Efficacy of Avonex in Subjects With Chronic Inflammatory Demyelinating Polyradiculoneuropathy (CIDP) - This study is no longer recruiting patients (Current: 23 Nov 2006)
• Intravenous Gammaglobulin - Study of CIDP Patients During IVIG Treatment - This study is currently recruiting patients (Current: 23 Nov 2006)
• Lenalidomide (CC-5013) - Study to Evaluate the Efficacy and Safety of Lenalidomide in the Treatment of Painful Lumbar Radiculopathy - This study is currently recruiting patients (Current: 23 Nov 2006)
• Levetiracetam - A Study to Determine If Levetiracetam Will Assist Those Suffering From Chronic Idiopathic Axonal Polyneuropathy. - This study is currently recruiting patients (Current: 23 Nov 2006)
• Levetiracetam - Efficacy and Safety of Levetiracetam in Adults With CIAP - This study is currently recruiting patients (Current: 23 Nov 2006)
• Levetiracetam - Levetiracetam for Painful Polyneuropathy - This study is currently recruiting patients (Current: 23 Nov 2006)
• Lidorestat (IDD 676) - Lidorestat (IDD 676) for the Treatment of Diabetic Neuropathy - This study is no longer recruiting patients (Current: 23 Nov 2006)
• MCC-257 - Safety and Efficacy of MCC-257 in the Treatment of Diabetic Polyneuropathy - This study is currently recruiting patients (Current: 23 Nov 2006)
• Morphine - Pain Treatment for Sciatica - This study is no longer recruiting patients (Current: 23 Nov 2006)
• Nortriptyline - Pain Treatment for Sciatica - This study is no longer recruiting patients (Current: 23 Nov 2006)
• Pregabalin - Effects of Pregabalin on Mechanical Hyperalgesia - This study is not yet open for patient recruitment (Current: 23 Nov 2006)
• Pregabalin - Trial of Efficacy and Safety of Pregabalin in Subjects With Neuropathic Pain Associated With Lumbo-Sacral Radiculopathy - This study is currently recruiting patients (Current: 23 Nov 2006)
• REN-1654 - Study of REN-1654 in Patients With Sciatica Pain - This study is no longer recruiting patients (Current: 23 Nov 2006)
• Ranirestat, (As-3201) - Safety and Efficacy of AS-3201 in the Treatment of Diabetic Sensorimotor Polyneuropathy - This study is no longer recruiting patients (Current: 23 Nov 2006)
• Rituximab - RIMAG Study: Trial of Rituximab Versus Placebo in Polyneuropathy Associated With Anti-MAG IgM Monoclonal Gammopathy - This study is not yet open for patient recruitment (Current: 23 Nov 2006)
• Rituximab - Rituximab to Treat Neuropathy With Anti-MAG Antibodies - This study is no longer recruiting patients (Current: 23 Nov 2006)
• TAK-128 - TAK-128 Effects on Diabetic Peripheral Neuropathy - This study is currently recruiting patients (Current: 23 Nov 2006)
• Thioctic Acid - Assessment of Efficacy and Safety of Thioctic Acid in the Oral Treatment of Symptomatic Diabetic Neuropathy (SYDNEY 2) - This study has been completed (Current: 23 Nov 2006)
• Topiramate - A Study To Evaluate The Effect Of Topiramate On Clinical And Electrophysiological Parameters In Subjects With Diabetic Peripheral Polyneuropathy. - This study is no longer recruiting patients (Current: 23 Nov 2006)

The trial data on this page has been sourced from

• The U.S. National Library of Medicine (NLM) together with ClinicalTrials.gov

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