Clinical Trials for Periodontitis
Clinical trials are research studies conducted in an effort to improve overall patient health and care.
Each trial involves running supervised tests to determine the effectiveness and safety of new drugs, procedures and/or devices with the aim of answering scientific questions about a disease or condition.
Risks and side-effects are also evaluated during these trials with results ranging from being unpleasant, with side effects such as headaches, to more serious or even life-threatening risks.
A clinical trial may be separated into phases, or steps, with each step designed to answer a separate research question. This maybe reflected in the trial name.
A brief description of each phase:
- Phase I: Usually designed to evaluate safety, determine a safe dosage range, and identify side effects on a small group of patients.
- Phase II: If Phase I is successful, the trial is then repeated with a larger group to further evaluate its effect and safety.
- Phase III: Trials are conducted on an ever larger group and are compared with the best current treatment while gathering more information on effect and safety.
- Phase IV: These studies monitor long-term side effects after the treatment has been marketed.
Clinical Trials data for Periodontitis is grouped into the following categories:-
The format for each of the following is:
- The name of the trial,
- followed by whether the trial is recruiting patients,
- The trial may not have started and not yet recruiting, or the trial may have started and do not need any more recruitements, or the trial may be completed.
- Note**: Please follow the link to determine the current trial status.
- followed by a list of drug/s, if any, used in the trial
ClinicalTrials.gov has listed the following trials for Periodontitis:
- Placebo Controlled Trial of a Titanium Dioxide Semiconductor Toothbrush on Mild-to-Moderate Gum Disease - This study is no longer recruiting patients (Current: 23 Nov 2006)
- Prevention of Pre-Term Birth by Treatment of Periodontal Disease - This study is currently recruiting patients (Current: 23 Nov 2006)
- "Clinical Trials to Enhance Elders' Oral Health" ("TEETH") - This study is no longer recruiting patients (Current: 23 Nov 2006) - Chlorhexidine rinse
- Norplant and Irregular Bleeding/Spotting - This study is currently recruiting patients (Current: 23 Nov 2006) - doxycycline
- Microbial Associations in Periodontal Health and Disease - This study is currently recruiting patients (Current: 23 Nov 2006) - Metronidazole
- Effect of Three Periodontal Therapies in Current Smokers and Non-Smokers - This study is currently recruiting patients (Current: 23 Nov 2006) - Group 1: metronidazole,Group 2: metronidazole + amoxicillin + locally delivered,doxycycline
- Periodontal Infection and Prematurity Study - This study is currently recruiting patients (Current: 23 Nov 2006)
- Study Comparing Two Different Methods of Treating Periodontal Disease - This study is no longer recruiting patients (Current: 23 Nov 2006)
- Regenafil Versus Demineralized Freeze Dried Bone Allograft for Periodontal Defects - This study is currently recruiting patients (Current: 23 Nov 2006)
- Randomized, Double Blind, Placebo-Controlled, Phase IIB Trial of Ketorolac Mouth Rinse Evaluating the Effect of Cyclooxygenase Inhibition on Oropharyngeal Leukoplakia: Collaborative Study of the NCI, NIDCD and the NIDCR - This study has been completed (Current: 23 Nov 2006) - Ketorolac Rinse
- Study of the Composition of Dental Plaque - This study is currently recruiting patients (Current: 23 Nov 2006)
- Treating Periodontal Infection: Effects on Glycemic Control in People With Type 2 Diabetes - This study is no longer recruiting patients (Current: 23 Nov 2006)
- Impact of Gum Infection on Heart Disease - This study is currently recruiting patients (Current: 23 Nov 2006)
- Effects of Periodontal Pathogens, Porphyromonas Gingivalis and Tannerella Forsythensis, on Cytokine Production From Human Monocyte-Derived Dendritic Cells - This study is currently recruiting patients (Current: 23 Nov 2006)
- Photodynamic Lasertherapy (PDT) in Periodontal Treatment (in Vivo) - This study has been completed (Current: 23 Nov 2006)
- Changes in Inflammatory State in Asian Americans Changing From Traditional Asian Diets to American Diet - a Pilot Study - This study is currently recruiting patients (Current: 23 Nov 2006)
- Genes Associated With Hereditary and Drug-Induced Gingival Overgrowth - This study is currently recruiting patients (Current: 23 Nov 2006)
- Complementary Naturopathic Medicine for Periodontitis - This study has been completed (Current: 23 Nov 2006) - Connective Tissue Nutrient Formula,Adaptogenic herbs,glutamine
- Biological Specifications for Denture Designs - This study has been completed (Current: 23 Nov 2006)
- Effects of Low-Dose Doxycycline on Oral Bone Loss - This study is no longer recruiting patients (Current: 23 Nov 2006) - 20 mg doxycycline hyclate
- Obstetrics and Periodontal Therapy (OPT) Study - This study is no longer recruiting patients (Current: 23 Nov 2006)
- MOTOR: Maternal Oral Therapy to Reduce Obstetric Risk - This study is currently recruiting patients (Current: 23 Nov 2006)
- The Occurrence of Periopathogens in Betel-Nut Chewers and the Effects of Areca-Nut on Periopathogens - This study has been completed (Current: 23 Nov 2006)
- A Phase2 Clinical Trial of Trafermin in Patients With Marginal Periodontitis in Japan - This study is currently recruiting patients (Current: 23 Nov 2006) - Trafermin(genetical recombination),Placebo
- Clinical Trials of Regeneration for Periodontal Tissue - This study is currently recruiting patients (Current: 23 Nov 2006)
- Immediate Implant Placement in the Molar Regions - This study is no longer recruiting patients (Current: 23 Nov 2006)
- Periapical Bone Healing After Apicectomy With and Without Retrograde Root Filling - This study is currently recruiting patients (Current: 23 Nov 2006)
- REPI : a Randomized Open Label Trial Evaluating the Use of APC in Pre-Implantation Reconstruction of Maxilla - This study is currently recruiting patients (Current: 23 Nov 2006)
- SRP in Combination With PERIOWAVE in Comparison to SRP Alone in Chronic Periodontitis - This study is currently recruiting patients (Current: 23 Nov 2006)
- Post-Market Study of Scaling and Root Planing (SRP) With PerioWave vs. SRP Alone in Chronic Periodontitis Using the Florida Probe - This study is currently recruiting patients (Current: 23 Nov 2006)
- Study of Scaling and Root Planing With PerioWave Versus Scaling and Root Planing Alone in Chronic Periodontitis - This study is currently recruiting patients (Current: 23 Nov 2006)
- Effect of Intensive Periodontal Therapy on Vascular Function - This study has been completed (Current: 23 Nov 2006)
- PerioWave Re-Treatment Protocol Compared to Scaling and Root Planing (SRP) and a Single Treatment With PerioWave - This study is no longer recruiting patients (Current: 23 Nov 2006)
- Effect of Adjunctive Treatment With Arestin on the Subgingival Microflora in Patients With Moderate to Advanced Periodontitis - This study has been completed (Current: 23 Nov 2006) - Minocycline HCL Microspheres
- Pilot Efficacy Study to Treat Gingivitis - This study is no longer recruiting patients (Current: 23 Nov 2006) - Frio Oral Rinse
- Immediate Implant Placement in the Molar Regions - This study is no longer recruiting patients (Current: 23 Nov 2006)
- Study of Scaling and Root Planing With PerioWave Versus Scaling and Root Planing Alone in Chronic Periodontitis - This study is currently recruiting patients (Current: 23 Nov 2006)
- PerioWave Re-Treatment Protocol Compared to Scaling and Root Planing (SRP) and a Single Treatment With PerioWave - This study is no longer recruiting patients (Current: 23 Nov 2006)
- Post-Market Study of Scaling and Root Planing (SRP) With PerioWave vs. SRP Alone in Chronic Periodontitis Using the Florida Probe - This study is currently recruiting patients (Current: 23 Nov 2006)
- Effect of Adjunctive Treatment With Arestin on the Subgingival Microflora in Patients With Moderate to Advanced Periodontitis - This study has been completed (Current: 23 Nov 2006) - Minocycline HCL Microspheres
- The Occurrence of Periopathogens in Betel-Nut Chewers and the Effects of Areca-Nut on Periopathogens - This study has been completed (Current: 23 Nov 2006)
- A Phase2 Clinical Trial of Trafermin in Patients With Marginal Periodontitis in Japan - This study is currently recruiting patients (Current: 23 Nov 2006) - Trafermin(genetical recombination),Placebo
- SRP in Combination With PERIOWAVE in Comparison to SRP Alone in Chronic Periodontitis - This study is currently recruiting patients (Current: 23 Nov 2006)
- Effect of Intensive Periodontal Therapy on Vascular Function - This study has been completed (Current: 23 Nov 2006)
- Complementary Naturopathic Medicine for Periodontitis - This study has been completed (Current: 23 Nov 2006) - Connective Tissue Nutrient Formula,Adaptogenic herbs,glutamine
- Microbial Associations in Periodontal Health and Disease - This study is currently recruiting patients (Current: 23 Nov 2006) - Metronidazole
- Effects of Low-Dose Doxycycline on Oral Bone Loss - This study is no longer recruiting patients (Current: 23 Nov 2006) - 20 mg doxycycline hyclate
- Effect of Three Periodontal Therapies in Current Smokers and Non-Smokers - This study is currently recruiting patients (Current: 23 Nov 2006) - Group 1: metronidazole,Group 2: metronidazole + amoxicillin + locally delivered,doxycycline
- Obstetrics and Periodontal Therapy (OPT) Study - This study is no longer recruiting patients (Current: 23 Nov 2006)
- MOTOR: Maternal Oral Therapy to Reduce Obstetric Risk - This study is currently recruiting patients (Current: 23 Nov 2006)
- Clinical Trials of Regeneration for Periodontal Tissue - This study is currently recruiting patients (Current: 23 Nov 2006)
- Chromogranin-A-Derived Peptides and Periodontitis in Diabetic Patients - This study is not yet open for patient recruitment (Current: 23 Nov 2006)
- Impact of Parathyroid Hormone (PTH) on Osseous Cavity - This study is currently recruiting patients (Current: 23 Nov 2006)
- Integrated Microfluidic System for Oral Diagnostics - This study is currently recruiting patients (Current: 23 Nov 2006)
- Longitudinal Endodontic Study of Apical Preparation Size - This study is currently recruiting patients (Current: 23 Nov 2006)
- Measurement of Bite Force in Humans - This study is currently recruiting patients (Current: 23 Nov 2006)
- Cytokine Regulation of Periradicular Pain in Humans - This study is currently recruiting patients (Current: 23 Nov 2006)
The format for each of the following is:
- The drug,
- followed by the name of the trial,
- followed by whether the trial is recruiting patients,
- The trial may not have started and not yet recruiting, or the trial may have started and do not need any more recruitements, or the trial may be completed.
- Note**: Please follow the link to determine the current trial status.
ClinicalTrials.gov has listed the following drugs in trials for Periodontitis:
The trial data on this page has been sourced from
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