Cure Research for Pancreatic cancer
Medications currently used in research into the treatment of Pancreatic cancer:
Note:You must always seek professional medical advice about any treatment
or change in treatment plans.
Some of the different medications being used in the research into treatment of Pancreatic cancer include:
Latest Treatments for Pancreatic cancer
Some of the more recent treatments for Pancreatic cancer include:
Treatments for Pancreatic cancer
Treatments to consider for Pancreatic cancer may include:
Medical Research Breakthroughs and Pancreatic cancer
Calorie restricted diet prevents Pancreatic Inflammation and Cancer: In a preclinical research reported by researchers from The University of Texas at Austin and The University of Texas M. D. Anderson Cancer Center at the
American Association for Cancer Research annual meeting, prevention of weight
gain with a restricted calorie diet sharply reduced the development of
pancreatic lesions that lead to cancer . The research sheds light on the links between obesity, caloric intake and
pancreatic cancer by comparing a calorie restricted diet, an overweight diet
and an obesity-inducing diet in a strain of mice that spontaneously develops
pancreatic lesions that lead to development of pancreatic cancer. Obesity is a known risk factor for pancreatic cancer, but the mechanism
underlying that relationship is unknown. The findings of the research indicate
that calorie restriction hinders development of pancreatic cancer, which could
have implications for prevention and treatment of pancreatic tumors caused by
chronic inflammation and obesity. The analysis of the research points to a connection between calorie intake and
a protein called Insulin-like Growth Factor (IGF) -1, with obesity increasing
and calorie restriction decreasing levels of IGF-1. IGF-1 is an important growth
factor known to stimulate the growth of many types of cancer cells.
Inflammatory signalling proteins also were found to be reduced in the blood of
the calorie-restricted mice. Mice on the heavier diets had significantly more lesions and larger lesions
than those on the restricted calorie diet. The decline in blood levels of
inflammatory proteins in the calorie restricted mice is because fat tissue is a
major source of inflammatory factors such as cytokines. While calorie
restriction has been shown to have an anti-cancer effect in multiple species
and for a variety of tumor types, its impact had not been well-studied in a
model of pancreatic cancer. Pancreatic cancer is the fourth leading cause of
cancer death and remains mostly intractable to existing treatments.
Cure Research discussion for Pancreatic cancer:
DPC4 (Smad4) homologs exist in the worm (Caenorhabditis elegans), mouse and the fly (Drosophila). In Drosophila, when the gene is not present, there a number of developmental defects. Likewise, homozygous Smad4 mutant mouse embryos die before embryonic day 7.5, and have reduced size because of reduced cell proliferation. Research on these model organisms should help elucidate the role of Smad4 and related proteins in humans.
(Source: Genes and Disease by the National Center for Biotechnology)
Medical research for Pancreatic cancer: medical news summaries:
The following medical news items
are relevant to medical research for Pancreatic cancer:
Pancreatic cancer Treatment: Book Excerpts
Clinical Trials for Pancreatic cancer
Some of the clinical trials for Pancreatic cancer include:
Evidence Based Medicine Research for Pancreatic cancer
Medical research papers related to Pancreatic cancer include:
- Larotaxel Pancreatic cancer - recurrent advanced and/or metastatic; 2nd line
- GV1001 Pancreatic cancer - advanced and/or metastatic
- Intraoperative radiotherapy in pancreatic cancer
- Pancreatic cancer
- Efficacy of gemcitabine plus axitinib compared with gemcitabine alone in patients with advanced pancreatic cancer: an open-label randomised phase II study.
- Statins are not associated with a reduced risk of pancreatic cancer at the population level, when taken at low doses for managing hypercholesterolemia: evidence from a meta-analysis of 12 studies
- Cetuximab plus gemcitabine and cisplatin compared with gemcitabine and cisplatin alone in patients with advanced pancreatic cancer: a randomised, multicentre, phase II trial
- What is the relationship between diabetes and pancreatic cancer?
- Clinical benefit and quality of life in patients with advanced pancreatic cancer receiving gemcitabine plus capecitabine versus gemcitabine alone
- I have a 59 yr old lady with a new diagnosis of Pancreatic cancer. Why does she experience a sweet taste all the time?
- Fluorouracil vs gemcitabine chemotherapy before and after fluorouracil-based chemoradiation following resection of pancreatic adenocarcinoma: a randomized controlled trial.
- Glycemic index, glycemic load, and cancer risk: a meta-analysis
- Octreotide for endocrine, oncologic, and gastrointestinal disorders: systematic review and budget impact analysis
- Pancreaticoduodenectomy (classic Whipple) versus pylorus-preserving pancreaticoduodenectomy (pp Whipple) for surgical treatment of periampullary and pancreatic carcinoma
- Artificial neural networks in pancreatic disease
- Pancreatic cancer
- Bevacizumab (Avastin) Pancreatic cancer ? first line, metastatic
- Meta-analysis: the use of non-steroidal anti-inflammatory drugs and pancreatic cancer risk for different exposure categories
- Gemcitabine-based combinations for inoperable pancreatic cancer: have we made real progress? A meta-analysis of 20 phase 3 trials
- Neurolytic celiac plexus block for pain control in unresectable pancreatic cancer
- Systematic review, including meta-analyses, on the management of locally advanced pancreatic cancer using radiation/combined modality therapy
- Systematic review and meta-analysis of standard and extended lymphadenectomy in pancreaticoduodenectomy for pancreatic cancer
- Using economic analysis to evaluate the potential of multimodality therapy for elderly patients with locally advanced pancreatic cancer
- Adjuvant chemotherapy with gemcitabine vs observation in patients undergoing curative-intent resection of pancreatic cancer: a randomized controlled trial.
- PancPRO: risk assessment for individuals with a family history of pancreatic cancer
- Dietary glycemic load, added sugars, and carbohydrates as risk factors for pancreatic cancer: the Multiethnic Cohort Study.
- Meta-analyses of chemotherapy for locally advanced and metastatic pancreatic cancer.
- Neurolytic Celiac Plexus Block for Pain Control in Unresectable Pancreatic Cancer.
- Erlotinib plus gemcitabine compared with gemcitabine alone in patients with advanced pancreatic cancer: a phase III trial of the National Cancer Institute of Canada Clinical Trials Group.
- Systematic review and meta-analysis of standard and extended lymphadenectomy in pancreaticoduodenectomy for pancreatic cancer.
Click here to find more evidence-based articles on the TRIP Database
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