Clinical Trials for Ovarian cysts

Clinical trials are research studies conducted in an effort to improve overall patient health and care. Each trial involves running supervised tests to determine the effectiveness and safety of new drugs, procedures and/or devices with the aim of answering scientific questions about a disease or condition. Risks and side-effects are also evaluated during these trials with results ranging from being unpleasant, with side effects such as headaches, to more serious or even life-threatening risks. A clinical trial may be separated into phases, or steps, with each step designed to answer a separate research question. This maybe reflected in the trial name.

A brief description of each phase:

• Phase I: Usually designed to evaluate safety, determine a safe dosage range, and identify side effects on a small group of patients.
• Phase II: If Phase I is successful, the trial is then repeated with a larger group to further evaluate its effect and safety.
• Phase III: Trials are conducted on an ever larger group and are compared with the best current treatment while gathering more information on effect and safety.
• Phase IV: These studies monitor long-term side effects after the treatment has been marketed.

Clinical Trials data for Ovarian cysts is grouped into the following categories:-

• View by trial name
• View by drugs used in Ovarian cysts clinical trials

Clinical Trials by trial name

The format for each of the following is:

• The name of the trial,
• followed by whether the trial is recruiting patients,
  - The trial may not have started and not yet recruiting, or the trial may have started and do not need any more recruitements, or the trial may be completed.
  - Note**: Please follow the link to determine the current trial status.
• followed by a list of drug/s, if any, used in the trial

ClinicalTrials.gov has listed the following trials for Ovarian cysts:

• Effect of Fetal Ovarian Cyst Aspiration to Prevent Torsion - This study is currently recruiting patients (Current: 23 Nov 2006)
• Phase II Study of the Effect of Leuprolide Acetate and Spironolactone on Insulin Resistance in Hyperandrogenic Women With Polycystic Ovarian Disease or Hyperandrogenism Insulin Resistance Acanthosis Nigricans Syndrome - This study has been completed (Current: 23 Nov 2006) - leuprolide acetate,spironolactone
• Randomized Study of Decreased Hyperinsulinemia on the Ovulatory Response to Clomiphene Citrate in Women With Polycystic Ovary Syndrome - This study has been completed (Current: 23 Nov 2006) - clomiphene citrate,metformin
• Risk of Coronary Heart Disease in Women With Polycystic Ovary Syndrome - This study is no longer recruiting patients (Current: 23 Nov 2006)
• Randomized Study of the Effect of Decreased Hyperinsulinemia on the Ovulatory Response to Clomiphene Citrate in Obese Women With Polycystic Ovary Syndrome - This study has been completed (Current: 23 Nov 2006) - clomiphene citrate,metformin
• Androgens and Subclinical Atherosclerosis in Young Women - Ancillary to CARDIA - This study has been completed (Current: 23 Nov 2006)
• Treatment of Infertility in Women With Polycystic Ovary Syndrome - This study is no longer recruiting patients (Current: 23 Nov 2006) - metformin XR,clomiphene citrate
• Prospective Study of Patients With Hirsutism - This study is no longer recruiting patients (Current: 23 Nov 2006)
• Pioglitazone Treatment in Polycystic Ovary Syndrome - This study is no longer recruiting patients (Current: 23 Nov 2006) - Tablet Actos, 30mg/day
• Body Composition, Glucose Metabolism, Insulin Resistance and Gene Expression in Muscle Cells in Healthy Overweight Women - This study is no longer recruiting patients (Current: 23 Nov 2006)
• Lifestyle Intervention and Metformin for Women With PCOS - This study is currently recruiting patients (Current: 23 Nov 2006) - Metformin
• Metformin in Pregnant PCOS Women - This study is currently recruiting patients (Current: 23 Nov 2006) - Metformin
• Metformin in Assisted Reproduction - This study is currently recruiting patients (Current: 23 Nov 2006) - Metformin / Placebo treatment for 4 months
• The Genetics of Polycystic Ovarian Syndrome - This study is currently recruiting patients (Current: 23 Nov 2006)
• Metabolic Disorders in Polycystic Ovarian Syndrome - This study is currently recruiting patients (Current: 23 Nov 2006)
• The Role of Insulin Resistance in PCOS - This study is currently recruiting patients (Current: 23 Nov 2006)
• Polycystic Ovary Syndrome (PCOS) and Sleep Apnea - This study is currently recruiting patients (Current: 23 Nov 2006) - depot leuprolide plus estrogen/progestin replacement,pioglitazone
• Comparison Between Laparoscopic Ovarian Diathermy and Clomiphene Citrate in Women With Anovulatory PCOS - This study is currently recruiting patients (Current: 23 Nov 2006)
• Efficacy Study of the OV-Watch Personal Fertility Monitor for Women Using Clomiphene Citrate. - This study is currently recruiting patients (Current: 23 Nov 2006)
• Impact of Metformin in Teens With Polycystic Ovary Syndrome (PCOS) on Oral Contraceptive Therapy - This study is currently recruiting patients (Current: 23 Nov 2006) - Metformin,Oral Contraceptive Pill
• Efficacy of Metformin in PCOS: Metabolic and Hormonal Factors - This study is no longer recruiting patients (Current: 23 Nov 2006) - Metformin
• Efficacy of Metformin in Lean Women With Polycystic Ovary Syndrome - This study is not yet open for patient recruitment (Current: 23 Nov 2006) - Metformin
• The Effect of Cinnamon Extract on Insulin Resistance Parameters in Polycystic Ovary Syndrome: A Pilot Study - This study has been completed (Current: 23 Nov 2006) - Oral Cinnamon Extract
• Environmental Factors in the Development of Polycystic Ovary Syndrome - This study is currently recruiting patients (Current: 23 Nov 2006)
• Exenatide and Metformin Therapy in Overweight Women With PCOS - This study is currently recruiting patients (Current: 23 Nov 2006) - metformin, exenatide or combined (metformin & exenatide )
• Intrauterine Environment in Polycystic Ovary Syndrome (PCOS) Probands - This study is currently recruiting patients (Current: 23 Nov 2006)
• Simvastatin Therapy in Women With Polycystic Ovary Syndrome. - This study has been completed (Current: 23 Nov 2006) - simvastatin
• Pulsatile GnRH in Anovulatory Infertility - This study is currently recruiting patients (Current: 23 Nov 2006) - GnRH
• Simvastatin and Metformin Therapy in PCOS Women. Prospective Randomised Trial. - This study is currently recruiting patients (Current: 23 Nov 2006) - Simvastatin,Simvastatin and Metformin,Metformin

Drugs used in Clinical Trials for Ovarian cysts

The format for each of the following is:

• The drug,
• followed by the name of the trial,
• followed by whether the trial is recruiting patients,
  - The trial may not have started and not yet recruiting, or the trial may have started and do not need any more recruitements, or the trial may be completed.
  - Note**: Please follow the link to determine the current trial status.

ClinicalTrials.gov has listed the following drugs in trials for Ovarian cysts:

• Clomiphene Citrate - Randomized Study of Decreased Hyperinsulinemia on the Ovulatory Response to Clomiphene Citrate in Women With Polycystic Ovary Syndrome - This study has been completed (Current: 23 Nov 2006)
• Clomiphene Citrate - Randomized Study of the Effect of Decreased Hyperinsulinemia on the Ovulatory Response to Clomiphene Citrate in Obese Women With Polycystic Ovary Syndrome - This study has been completed (Current: 23 Nov 2006)
• Clomiphene Citrate - Treatment of Infertility in Women With Polycystic Ovary Syndrome - This study is no longer recruiting patients (Current: 23 Nov 2006)
• Depot Leuprolide Plus Estrogen/Progestin Replacement - Polycystic Ovary Syndrome (PCOS) and Sleep Apnea - This study is currently recruiting patients (Current: 23 Nov 2006)
• GnRH - Pulsatile GnRH in Anovulatory Infertility - This study is currently recruiting patients (Current: 23 Nov 2006)
• Leuprolide Acetate - Phase II Study of the Effect of Leuprolide Acetate and Spironolactone on Insulin Resistance in Hyperandrogenic Women With Polycystic Ovarian Disease or Hyperandrogenism Insulin Resistance Acanthosis Nigricans Syndrome - This study has been completed (Current: 23 Nov 2006)
• Metformin / Placebo treatment for 4 months - Metformin in Assisted Reproduction - This study is currently recruiting patients (Current: 23 Nov 2006)
• Metformin Xr - Treatment of Infertility in Women With Polycystic Ovary Syndrome - This study is no longer recruiting patients (Current: 23 Nov 2006)
• Metformin, Exenatide Or Combined (Metformin &Amp; Exenatide ) - Exenatide and Metformin Therapy in Overweight Women With PCOS - This study is currently recruiting patients (Current: 23 Nov 2006)
• Metformin - Efficacy of Metformin in Lean Women With Polycystic Ovary Syndrome - This study is not yet open for patient recruitment (Current: 23 Nov 2006)
• Metformin - Efficacy of Metformin in PCOS: Metabolic and Hormonal Factors - This study is no longer recruiting patients (Current: 23 Nov 2006)
• Metformin - Impact of Metformin in Teens With Polycystic Ovary Syndrome (PCOS) on Oral Contraceptive Therapy - This study is currently recruiting patients (Current: 23 Nov 2006)
• Metformin - Lifestyle Intervention and Metformin for Women With PCOS - This study is currently recruiting patients (Current: 23 Nov 2006)
• Metformin - Metformin in Pregnant PCOS Women - This study is currently recruiting patients (Current: 23 Nov 2006)
• Metformin - Randomized Study of Decreased Hyperinsulinemia on the Ovulatory Response to Clomiphene Citrate in Women With Polycystic Ovary Syndrome - This study has been completed (Current: 23 Nov 2006)
• Metformin - Randomized Study of the Effect of Decreased Hyperinsulinemia on the Ovulatory Response to Clomiphene Citrate in Obese Women With Polycystic Ovary Syndrome - This study has been completed (Current: 23 Nov 2006)
• Metformin - Simvastatin and Metformin Therapy in PCOS Women. Prospective Randomised Trial. - This study is currently recruiting patients (Current: 23 Nov 2006)
• Oral Cinnamon Extract - The Effect of Cinnamon Extract on Insulin Resistance Parameters in Polycystic Ovary Syndrome: A Pilot Study - This study has been completed (Current: 23 Nov 2006)
• Oral Contraceptive Pill - Impact of Metformin in Teens With Polycystic Ovary Syndrome (PCOS) on Oral Contraceptive Therapy - This study is currently recruiting patients (Current: 23 Nov 2006)
• Pioglitazone - Polycystic Ovary Syndrome (PCOS) and Sleep Apnea - This study is currently recruiting patients (Current: 23 Nov 2006)
• Simvastatin and Metformin - Simvastatin and Metformin Therapy in PCOS Women. Prospective Randomised Trial. - This study is currently recruiting patients (Current: 23 Nov 2006)
• Simvastatin - Simvastatin Therapy in Women With Polycystic Ovary Syndrome. - This study has been completed (Current: 23 Nov 2006)
• Simvastatin - Simvastatin and Metformin Therapy in PCOS Women. Prospective Randomised Trial. - This study is currently recruiting patients (Current: 23 Nov 2006)
• Spironolactone - Phase II Study of the Effect of Leuprolide Acetate and Spironolactone on Insulin Resistance in Hyperandrogenic Women With Polycystic Ovarian Disease or Hyperandrogenism Insulin Resistance Acanthosis Nigricans Syndrome - This study has been completed (Current: 23 Nov 2006)
• Tablet Actos, 30mg/day - Pioglitazone Treatment in Polycystic Ovary Syndrome - This study is no longer recruiting patients (Current: 23 Nov 2006)

The trial data on this page has been sourced from

• The U.S. National Library of Medicine (NLM) together with ClinicalTrials.gov

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