Triiodothyronine

Introduction: Triiodothyronine

Description of Triiodothyronine

Triiodothyronine: A therapeutic formulation of the primary physiologically active form of endogenous thyroid hormone. In vivo, triiodothyronine enters the nucleus and binds to nuclear thyroid hormone receptors that subsequently bind to thyroid response elements (TREs) located in target genes. Receptor binding by triiodothyronine in combination with recruited coactivators results in maximal transcriptional activation after binding to TREs; in general, binding of thyroid hormone receptor alone to TREs leads to repression of gene transcription (NCI04)
Source: Diseases Database

Triiodothyronine: one of the thyroid hormones; an organic iodine containing compound secreted in small amounts by the thyroid gland; most circulating triiodothyroinine is produced by the deiodination of thyroxine in the peripheral tissues.
Source: CRISP

Triiodothyronine: A T3 thyroid hormone normally synthesized and secreted by the thyroid gland in much smaller quantities than thyroxine (T4). Most T3 is derived from peripheral monodeiodination of T4 at the 5' position of the outer ring of the iodothyronine nucleus. The hormone finally delivered and used by the tissues is mainly T3.
Source: MeSH 2007

Triiodothyronine as an Organ

Triiodothyronine (organ): Triiodothyronine is one of the thyroid hormones, chemical substances that play a big role in regulating many of the body's processes. Triiodothyronine is important to proper protein synthesis, development of all the body's cells, and bone growth. It also regulates metabolism and energy production and body temperature. Iodine is vital to the normal production of triiodothyronine, which is secreted by the thyroid epithelial cells. Its secretion is controlled by thyroid-stimulating hormone.

Conditions that can afflict triiodothyronine include hypothyroidism, hyperthyroidism, thyroid cancer, thyroid nodules, iodine deficiency, goiter, Grave's disease, trauma, and hypopituitarism.

Triiodothyronine (organ): See Triiodothyronine (organ information).

More information on organs: Triiodothyronine:

• Triiodothyronine

Terms associated with Triiodothyronine:

Terms Similar to Triiodothyronine:

• Liothyronine
• T3

Source: Diseases Database

• Liothyronine
• T3 Thyroid Hormone

Source - MeSH 2007

Related Topics

• Receptors, Thyroid Hormone

Source - MeSH 2007

Broader terms for Triiodothyronine

• Thyronines

Source - MeSH 2007

• thyroid hormone

Source - CRISP

The description of Triiodothyronine may also be used for the following terms:

• T3

Source: CRISP

Hierarchical classifications of Triiodothyronine

The following list attempts to classify Triiodothyronine into categories where each line is subset of the next.

MeSH 2007 Hierarchy:

• Hormones, Hormone Substitutes, and Hormone Antagonists
  • Hormones
    • Thyroid Hormones
      • Thyronines
        • Triiodothyronine

MeSH 2007 Hierarchy

• Amino Acids, Peptides, and Proteins
  • Amino Acids
    • Amino Acids, Cyclic
      • Amino Acids, Aromatic
        • Thyroxine
          • Thyronines
            • Triiodothyronine

External links related to: Triiodothyronine

• eMedicine - Toxicity, Thyroid Hormone : Article by Lisandro Irizarry, MD, MPH, FAAEM
• Cytomel Online, Description, Chemistry, Ingredients - Liothyronine Sodium - RxList Monographs

Source: Diseases Database

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