Raloxifene

Introduction: Raloxifene

Description of Raloxifene

Raloxifene: A selective estrogen receptor modulator (SERM) that has estrogen-agonistic effects on bone and lipid metabolism but estrogen-antagonistic effects on breast and uterus; used in the prophylaxis of osteoporosis after menopause.Raloxifene is a benzothiophene derivative that binds to estrogen receptor sites. Besides conferring protection against osteoporosis after menopause, it has been shown to improve bone mineral density and reduce the risk of fractures in established osteoporosis. The reduction in fracture risk is greater than would be expected from the increase in bone density. Unlike tamoxifen, which also reduces osteoporosis risk, raloxifene does not heighten the risk of endometrial cancer. Although raloxifene increases bone mineral density to a lesser degree than estrogen, it reduces the risk of breast cancer rather than increasing it as estrogen does. Hence it may be preferred for women who fear breast cancer or are at high risk for it. Like hormone replacement therapy with estrogen-progestogen, raloxifene decreases LDL cholesterol, fibrinogen, and lipoprotein Lp(a), thus increasing HDL cholesterol without raising triglycerides. It has no effect on the risk of adverse cardiovascular events (myocardial infarction, unstable angina, stroke) in women at normal risk before therapy, but significantly reduces the risk of adverse outcomes in women with a prior history of myocardial infarction, coronary artery bypass graft, or percutaneous transluminal coronary angioplasty, and in those with several risk factors combined (e.g., diabetes mellitus, hyperlipidemia, hypertension, cigarette smoking). Raloxifene does not relieve hot flashes; in fact, it causes them in 25% of patients. It is contraindicated in pregnancy and in women with a history of thromboembolism.
Source: Stedman's Medical Spellchecker, © 2006 Lippincott Williams & Wilkins. All rights reserved.

Raloxifene: A drug that belongs to the family of drugs called selective estrogen receptor modulators (SERMs) and is used in the prevention of osteoporosis in postmenopausal women. Raloxifene is also being studied as a cancer prevention drug.
Source: National Institute of Health

Raloxifene: A selective benzothiophene estrogen receptor modulator (SERM). Raloxifene binds to and interacts with estrogen receptors (ER) as a mixed estrogen agonist/antagonist; it displays both an ER-alpha-selective partial agonist/antagonist effect and a pure ER-beta-selective antagonist effect. This agent functions as an estrogen agonist in some tissues (bones, lipid metabolism) and as an estrogen antagonist in others (endometrium and breasts), with the potential for producing some of estrogen's beneficial effects without producing its adverse effects. In postmenopausal women, raloxifene may reduce the risk of strokes, osteoporosis and breast cancer. (NCI04)
Source: Diseases Database

Raloxifene: a selective estrogen receptor modulator; has both agonist and antagonist estrogen action.
Source: CRISP

Raloxifene: A second generation selective estrogen receptor modulator (SERM) used to prevent osteoporosis in postmenopausal women. It has estrogen agonist effects on bone and cholesterol metabolism but behaves as a complete estrogen antagonist on mammary gland and uterine tissue.
Source: MeSH 2007

Terms associated with Raloxifene:

Broader terms for Raloxifene

• Tamoxifen

Source - MeSH 2007

• estrogen analog
• estrogen inhibitor
• selective estrogen receptor modulator

Source - CRISP

The term Raloxifene can be used for:

• evista

Source: CRISP

Hierarchical classifications of Raloxifene

The following list attempts to classify Raloxifene into categories where each line is subset of the next.

MeSH 2007 Hierarchy:

• Organic Chemicals
  • Hydrocarbons
    • Hydrocarbons, Cyclic
      • Hydrocarbons, Aromatic
        • Benzene Derivatives
          • Benzylidene Compounds
            • Stilbenes
              • Tamoxifen
                • Raloxifene

External links related to: Raloxifene

• Newly Approved Drug Therapies (354): Evista, Eli Lilly
• Evista Online, Description, Chemistry, Ingredients - Raloxifene - RxList Monographs
• Evista Online, Description, Chemistry, Ingredients - Raloxifene - RxList Monographs

Source: Diseases Database

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