Muscle Weakness
Muscle Weakness: Excerpt from A Pocket Manual of Differential Diagnosis
Acute or Subacute*
Electrolyte abnormality
Hyperkalemia
Hypokalemia
Hypercalcemia
Hypermagnesemia
Hypophosphatemia
Rhabdomyolysis
Extreme muscular exertion
Prolonged seizures
Hyperthermia
Extensive crush injury or muscle infarction
Influenza
Hypokalemia
Hypophosphatemia
Alcoholic myopathy
Snake venoms
Industrial toxin ingestion
Familial myoglobinuria
Metabolic myopathies (e.g., McArdle's disease)
Polymyositis, dermatomyositis
Infection, especially
Viral
Influenza
Coxsackievirus infection
Rabies
Poliomyelitis
Herpes zoster
Trichinosis
Toxoplasmosis
Botulism
Diphtheria
Leprosy
Cysticercosis
Schistosomiasis
Trypanosomiasis
Landry-Guillain-Barré-Strohl syndrome
Peripheral neuropathy, acute
Thyrotoxicosis
Corticosteroid therapy
Organophosphorous poisoning
Chronic
Progressive muscular dystrophies, especially
Oculopharyngeal
Duchenne's
Facioscapulohumeral
Limb-girdle
Myotonic
Endocrine disorders
Hyperthyroidism or hypothyroidism
Hyperparathyroidism
Vitamin D deficiency (e.g., vitamin D–deficiency rickets)
Corticosteroid therapy
Cushing's syndrome and Addison's disease
Acromegaly
Connective-tissue disease
Lupus erythematosus
Rheumatoid arthritis
Polymyositis, dermatomyositis
Sjögren's syndrome
Mixed connective tissue disease
Alcoholic myopathy
Chronic polymyopathy
Glycogen storage diseases (e.g., McArdle's disease)
Central core disease
Mitochondrial myopathy
Lipid metabolism disorders (e.g., carnitine deficiency)
Familial periodic paralysis with progressive myopathy
Progressive neural-muscular atrophy
Amyotrophic lateral sclerosis
Multiple sclerosis
Werdnig-Hoffman disease
Peroneal muscular atrophy (Charcot-Marie-Tooth disease)
Chronic peripheral neuropathy (e.g., arsenic, lead, nutritional)
Intermittent or Transient, or Both
Electrolyte abnormality
Hypokalemia
Hyperkalemia
Hypophosphatemia
Hypercalcemia
Hypermagnesemia
Hyperkalemic or (sodium channel disorders)
Hypokalemic periodic paralysis (calcium channel disorders)
Drugs
Aminoglycosides (especially neomycin, streptomycin, kanamycin, polymyxin B)
Steroids
Vincristine, zidovudine, cyclosporin
Chloroquine
Bretylium
Clofibrate, pravastatin, gemfibrozil, niacin, lovastatin
Myasthenia gravis
Eaton-Lambert syndrome
Acute thyrotoxic myopathy
Thyrotoxic periodic paralysis
Paramyotonia congenita
Adynamia episodica hereditaria
References
1. Mendell J, Griggs R, Ptacek L: Diseases of Nerve and Muscle, pp. 2473–2483. See Bibliography, 1.
2. Miller M, Phelps P: Weakness, p. 388. See Bibliography, 2.
*Developing over days to weeks. (See Intermittent or Transient, or Both section)
Book Source Details
- Book Title: A Pocket Manual of Differential Diagnosis
- Author(s): Stephen N. Adler, Dianne B. Gasbarra
- Year of Publication: 1999
- Copyright Details: A Pocket Manual of Differential Diagnosis, Copyright © 1999 Lippincott Williams & Wilkins.
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