Male Hypogonadism

Male Hypogonadism: Excerpt from A Pocket Manual of Differential Diagnosis

Primary

Acquired
   Adult seminiferous tubule failure
   Amyloidosis
   Autoimmune destruction
   Cryptorchidism
   Drugs
       Chemotherapy
       Ethanol
       Ketoconazole
       Marijuana
       Spironolactone
   Granulomatous disease
       Leprosy
   Leukemia
   Viral orchitis
       Mumps
   Polyarteritis nodosa
   Radiation
   Surgery (castration)
   Trauma
Developmental
   Congenital anorchia
   Decreased responsiveness to testosterone (male pseudohermaphroditism)
       Reifenstein's syndrome
   5α-Reductase deficiency
   Defective testosterone biosynthesis
   Functional prepubertal castrate (vanishing testes
syndrome)
   Klinefelter's syndrome
   Luteinizing hormone (LH) resistant testes
   Myotonic dystrophy
   Persistent müllerian duct syndrome
   Sertoli-cell only syndrome
   Ullrich-Noonan syndrome (male Turner syndrome)
   XY/XO mixed gonadal dysgenesis
   XX male
   XYY syndrome

Secondary (Pituitary) or Tertiary (Hypothalamic)

Hypopituitarism
Congenital adrenal hyperplasia
Constitutional delay of puberty
Cushing's syndrome
Estrogen-secreting tumors
Exposure to estrogen in embalming compounds
Fröhlich's syndrome
Hyperprolactinemia
Hypopituitarism
Idiopathic hypogonadotropic hypogonadism (may be adult onset)
Isolated gonadotropin deficiency
   Hypogonadotropic eunuchoidism
       Complete (Kallman's syndrome)
       Partial
          Inherited immunologically active, biologically inactive LH
          Predominant LH deficiency, “fertile eunuch” syndrome
       Variant form (isolated follicle-stimulating hormone deficiency)
   Specific genetic syndromes
       Bardet-Biedl syndrome
       Börjeson-Forssman-Lehman syndrome
       Central nervous system (CNS) anomalies, genital hypoplasia, and ear anomalies and/or deafness (CHARGE) syndrome
       Laurence-Moon syndrome
       Lowe's syndrome
       Martsolf syndrome
       Möbius syndrome
       Multiple lentigines (leopard syndrome)
       Prader-Labhart-Willi syndrome
       Rothmund-Thomson syndrome
       Rud's syndrome
       Steroid sulfatase deficiency
Morbid obesity
Pituitary dwarfism
Severe illness (acute or chronic)
Withdrawal of androgen therapy (temporary)

Combined Primary and Secondary

Aging
Cirrhosis
Sickle cell disease

References

1. Plymate SR: Male Hypogonadism, pp. 1057–1079. See Bibliography, 2.
2. Santen RJ: The Testis, pp. 916–935. See Bibliography, 6.

Book Source Details

• Book Title: A Pocket Manual of Differential Diagnosis
• Author(s): Stephen N. Adler, Dianne B. Gasbarra
• Year of Publication: 1999
• Copyright Details: A Pocket Manual of Differential Diagnosis, Copyright © 1999 Lippincott Williams & Wilkins.

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More About This Book: Title: A Pocket Manual of Differential Diagnosis Authors: Stephen N. Adler, Dianne B. Gasbarra Publisher: Lippincott Williams & Wilkins Copyright: 1999 ISBN: 0-78171-943-7

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