Holoprosencephaly is listed as a "rare disease" by the Office of Rare Diseases (ORD) of the National Institutes of Health (NIH). This means that Holoprosencephaly, or a subtype of Holoprosencephaly, affects less than 200,000 people in the US population.
Source - National Institutes of Health (NIH)
Ophanet, a consortium of European partners, currently defines a condition rare when it affects 1 person per 2,000. They list Holoprosencephaly as a "rare disease".
Source - Orphanet
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