Inheritance and Genetics of Hemophilia

Hemophilia Genetics: Book Excerpts

Hemophilia - genetics - Hemophilia

Inheritance of Hemophilia:

X-linked recessive diseases are usually inherited by males from their mother. Rare cases of sporadic genetic disease can also occur. See inheritance of x-linked recessive diseases.

Hemophilia: Inheritance and Genetics Details

Inheritance properties of Hemophilia:

Disease inherited from: Usually inherited by males from their mother who is a carrier; see inheritance of x-linked recessive diseases.

Gender bias in inheritance: Males only get x-linked recessive diseases; females are carriers.

Inheritance Patterns

Inheritance odds for Hemophilia:

Overall odds of inheritance: Usually inherited by males from their mother who is a carrier; see inheritance of x-linked recessive diseases.

Sibling of diseased child odds of inheriting disease: About 50% for a second child if one (male) child already has the x-linked recessive disease.

Mother to son inheritance odds: 50% disease, 50% disease-free, males cannot be a carrier of an x-linked recessive disease.

Father to son inheritance odds: 0% chance usually for x-linked recessive diseases.

Mother to daughter inheritance odds: 0% disease; 50% female carrier, 50% chance neither affected nor carrier.

Father to daughter inheritance odds: 0% chance of x-linked recessive disease; 100% chance the female child is a carrier.

Inheritance Features

Inheritance features for Hemophilia:

Sporadic form of disease possible?: Yes, requires single mutation for x-linked recessive disease.

Milder form of disease possible in females?: Yes, females have mild disease for some x-linked recessive diseases.

About inheritance and genetics:

Inheritance of Hemophilia refers to whether the condition is inherited from your parents or "runs" in families. The level of inheritance of a condition depends on how important genetics are to the disease. Strongly genetic diseases are usually inherited, partially genetic diseases are sometimes inherited, and non-genetic diseases are not inherited. For general information, see Introduction to Genetics.