Clinical Trials for Hemochromatosis

Clinical trials are research studies conducted in an effort to improve overall patient health and care. Each trial involves running supervised tests to determine the effectiveness and safety of new drugs, procedures and/or devices with the aim of answering scientific questions about a disease or condition. Risks and side-effects are also evaluated during these trials with results ranging from being unpleasant, with side effects such as headaches, to more serious or even life-threatening risks. A clinical trial may be separated into phases, or steps, with each step designed to answer a separate research question. This maybe reflected in the trial name.

A brief description of each phase:

• Phase I: Usually designed to evaluate safety, determine a safe dosage range, and identify side effects on a small group of patients.
• Phase II: If Phase I is successful, the trial is then repeated with a larger group to further evaluate its effect and safety.
• Phase III: Trials are conducted on an ever larger group and are compared with the best current treatment while gathering more information on effect and safety.
• Phase IV: These studies monitor long-term side effects after the treatment has been marketed.

Clinical Trials data for Hemochromatosis is grouped into the following categories:-

• View by trial name
• View by drugs used in Hemochromatosis clinical trials

Clinical Trials by trial name

The format for each of the following is:

• The name of the trial,
• followed by whether the trial is recruiting patients,
  - The trial may not have started and not yet recruiting, or the trial may have started and do not need any more recruitements, or the trial may be completed.
  - Note**: Please follow the link to determine the current trial status.
• followed by a list of drug/s, if any, used in the trial

ClinicalTrials.gov has listed the following trials for Hemochromatosis:

• Iron Overload in African Americans - This study has been completed (Current: 23 Nov 2006)
• Study Using Deferiprone Alone or in Combination With Desferrioxamine in Iron Overloaded Transfusion-Dependent Patients - This study is currently recruiting patients (Current: 23 Nov 2006) - Deferiprone (L1),Desferrioxamine
• Study With Deferiprone and/or Desferrioxamine in Iron Overloaded Patients - This study is no longer recruiting patients (Current: 23 Nov 2006) - Deferiprone (L1),Desferrioxamine
• Treatment of Hemochromatosis - This study is currently recruiting patients (Current: 23 Nov 2006)
• Cardiac Function in Patients With Hereditary Hemochromatosis - This study is currently recruiting patients (Current: 23 Nov 2006)
• Research Network for Neonatal Diseases Induced by Tissular Fetomaternal Alloimmunization - This study is currently recruiting patients (Current: 23 Nov 2006)
• Safety and Efficacy of Deferasirox (ICL670) in Patients With Iron Overload Resulting From Hereditary Hemochromatosis - This study is currently recruiting patients (Current: 23 Nov 2006) - deferasirox
• Evaluation of Subcutaneous Desferrioxamine as Treatment for Transfusional Hemochromatosis - This study has been completed (Current: 23 Nov 2006) - deferoxamine
• Deferoxamine for the Treatment of Hemochromatosis - This study is no longer recruiting patients (Current: 23 Nov 2006)
• Hemochromatosis and Iron Overload Screening Study (HEIRS) - This study is no longer recruiting patients (Current: 23 Nov 2006)
• Statistical Basis for Hemochromatosis Screening - This study has been completed (Current: 23 Nov 2006)
• Hemochromatosis--Genetic Prevalence and Penetrance - This study has been completed (Current: 23 Nov 2006)
• Stroke With Transfusions Changing to Hydroxyurea (SWiTCH) - This study is no longer recruiting patients (Current: 23 Nov 2006) - Hydroxyurea
• Haemochromatosis:Phlebotomy Versus Erythrocytapheresis Therapy - This study is currently recruiting patients (Current: 23 Nov 2006)
• Screening of Hepatocellular Carcinoma in Patients With Compensated Cirrhosis - This study is currently recruiting patients (Current: 23 Nov 2006)
• Risk Factors of Porphyria Cutanea Tarda (PCT) - This study has been completed (Current: 23 Nov 2006)
• Cytochrome P450 2E1 and Iron Overload - This study has been completed (Current: 23 Nov 2006)
• Study of Deferasirox Relative to Subcutaneous Deferoxamine in Sickle Cell Disease Patients - This study is currently recruiting patients (Current: 23 Nov 2006) - Deferasirox
• Iron Overload in African Americans - This study has been completed (Current: 23 Nov 2006)
• Chelation Therapy of Iron Overload With Pyridoxal Isonicotinoyl Hydrazone - This study has been completed (Current: 23 Nov 2006) - chelation therapy
• Evaluation of Subcutaneous Desferrioxamine as Treatment for Transfusional Hemochromatosis - This study has been completed (Current: 23 Nov 2006) - deferoxamine
• Thalassemia (Cooley's Anemia) Clinical Research Network (TCRN) - This study is currently recruiting patients (Current: 23 Nov 2006) - Pamidronate,Ribavirin,Deferoxamine,Deferiprone,Arginine
• Combination Iron Chelation Therapy - This study has been completed (Current: 23 Nov 2006) - Combination Iron Chelation Therapy
• Hemochromatosis and Iron Overload Screening Study (HEIRS) - This study is no longer recruiting patients (Current: 23 Nov 2006)
• Study of Deferasirox for Treatment of Transfusional Iron Overload in Myelodysplastic Patients - This study is currently recruiting patients (Current: 23 Nov 2006) - Deferasirox
• Study for the Treatment of Transfusional Iron Overload in Myelodysplastic Patients - This study is currently recruiting patients (Current: 23 Nov 2006) - deferasirox
• Compassionate Use of Deferiprone - This study is not yet open for patient recruitment (Current: 23 Nov 2006) - Deferiprone (Ferriprox, L1)
• Study of the Effects of Muscular Activity on Iron Metabolism: a Pilot Study on Healthy Volunteers. - This study is not yet open for patient recruitment (Current: 23 Nov 2006)
• Quantification of Liver Iron Overload and Steatosis Using Magnetic Resonance Imaging - This study is not yet open for patient recruitment (Current: 23 Nov 2006)
• Treatment of Hemochromatosis - This study is currently recruiting patients (Current: 23 Nov 2006)
• Extension Study of Iron Chelation Therapy With Deferasirox in Patients With Transfusional Iron Overload - This study is no longer recruiting patients (Current: 23 Nov 2006) - Deferasirox
• An Extension Study of Iron Chelation Therapy With Deferasirox in -Thalassemia Patients With Transfusional Iron Overload - This study is no longer recruiting patients (Current: 23 Nov 2006) - Deferasirox
• Iron Chelation Therapy With Deferasirox in -Thalassemia Major Pediatric Patients With Transfusional Iron Overload - This study is no longer recruiting patients (Current: 23 Nov 2006) - Deferasirox
• Extension Study of Iron Chelation Therapy With Deferasirox in -Thalassemia and Other Patients With Rare Chronic Anemia and Transfusional Iron Overload - This study is no longer recruiting patients (Current: 23 Nov 2006) - Deferasirox
• Cardiac Function in Patients With Hereditary Hemochromatosis - This study is currently recruiting patients (Current: 23 Nov 2006)
• Efficacy Study in Removing Excess Iron From the Heart - This study has been completed (Current: 23 Nov 2006) - Ferriprox (deferiprone),Desferal (deferoxamine)
• Study Using Deferiprone Alone or in Combination With Desferrioxamine in Iron Overloaded Transfusion-Dependent Patients - This study is currently recruiting patients (Current: 23 Nov 2006) - Deferiprone (L1),Desferrioxamine
• Study With Deferiprone and/or Desferrioxamine in Iron Overloaded Patients - This study is no longer recruiting patients (Current: 23 Nov 2006) - Deferiprone (L1),Desferrioxamine
• Safety and Efficacy of Deferasirox (ICL670) in Patients With Iron Overload Resulting From Hereditary Hemochromatosis - This study is currently recruiting patients (Current: 23 Nov 2006) - deferasirox
• A Study Assessing the Efficacy and Safety of Deferasirox in Patients With Transfusion-Dependent Iron Overload - This study is currently recruiting patients (Current: 23 Nov 2006) - Deferasirox
• Deferoxamine for the Treatment of Hemochromatosis - This study is no longer recruiting patients (Current: 23 Nov 2006)
• Statistical Basis for Hemochromatosis Screening - This study has been completed (Current: 23 Nov 2006)
• Hemochromatosis--Genetic Prevalence and Penetrance - This study has been completed (Current: 23 Nov 2006)
• Stroke With Transfusions Changing to Hydroxyurea (SWiTCH) - This study is no longer recruiting patients (Current: 23 Nov 2006) - Hydroxyurea
• Research Network for Neonatal Diseases Induced by Tissular Fetomaternal Alloimmunization - This study is currently recruiting patients (Current: 23 Nov 2006)
• Haemochromatosis:Phlebotomy Versus Erythrocytapheresis Therapy - This study is currently recruiting patients (Current: 23 Nov 2006)
• A 1-Year Extension Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Effects on Liver Iron Concentration of Deferasirox and Deferoxamine in Children and Adults With Sickle Cell Disease and Transfusional Hemosiderosis - This study is no longer recruiting patients (Current: 23 Nov 2006) - Deferasirox
• Expanded Access of Deferasirox to Patients With Congenital Disorders of Red Blood Cells and Chronic Iron Overload. - This study is currently recruiting patients (Current: 23 Nov 2006) - Deferasirox
• Study of Deferasirox in Iron Overload From Beta-Thalassemia Unable to Be Treated With Deferoxamine or Chronic Anemias - This study is no longer recruiting patients (Current: 23 Nov 2006) - Deferasirox
• Safety of ICL670 Vs. Deferoxamine in Sickle Cell Disease Patients With Iron Overload Due to Blood Transfusions - This study is no longer recruiting patients (Current: 23 Nov 2006) - ICL670,deferoxamine
• Safety & Efficacy of ICL670 Vs. Deferoxamine in Beta-Thalassemia Patients With Iron Overload Due to Blood Transfusions - This study has been completed (Current: 23 Nov 2006) - ICL670,deferoxamine

Drugs used in Clinical Trials for Hemochromatosis

The format for each of the following is:

• The drug,
• followed by the name of the trial,
• followed by whether the trial is recruiting patients,
  - The trial may not have started and not yet recruiting, or the trial may have started and do not need any more recruitements, or the trial may be completed.
  - Note**: Please follow the link to determine the current trial status.

ClinicalTrials.gov has listed the following drugs in trials for Hemochromatosis:

• Deferasirox - Safety and Efficacy of Deferasirox (ICL670) in Patients With Iron Overload Resulting From Hereditary Hemochromatosis - This study is currently recruiting patients (Current: 23 Nov 2006)
• Deferiprone (L1) - Study Using Deferiprone Alone or in Combination With Desferrioxamine in Iron Overloaded Transfusion-Dependent Patients - This study is currently recruiting patients (Current: 23 Nov 2006)
• Deferiprone (L1) - Study With Deferiprone and/or Desferrioxamine in Iron Overloaded Patients - This study is no longer recruiting patients (Current: 23 Nov 2006)
• Deferoxamine - Evaluation of Subcutaneous Desferrioxamine as Treatment for Transfusional Hemochromatosis - This study has been completed (Current: 23 Nov 2006)
• Desferrioxamine - Study Using Deferiprone Alone or in Combination With Desferrioxamine in Iron Overloaded Transfusion-Dependent Patients - This study is currently recruiting patients (Current: 23 Nov 2006)
• Desferrioxamine - Study With Deferiprone and/or Desferrioxamine in Iron Overloaded Patients - This study is no longer recruiting patients (Current: 23 Nov 2006)
• Hydroxyurea - Stroke With Transfusions Changing to Hydroxyurea (SWiTCH) - This study is no longer recruiting patients (Current: 23 Nov 2006)
• Arginine - Thalassemia (Cooley's Anemia) Clinical Research Network (TCRN) - This study is currently recruiting patients (Current: 23 Nov 2006)
• Chelation Therapy - Chelation Therapy of Iron Overload With Pyridoxal Isonicotinoyl Hydrazone - This study has been completed (Current: 23 Nov 2006)
• Combination Iron Chelation Therapy - Combination Iron Chelation Therapy - This study has been completed (Current: 23 Nov 2006)
• Deferasirox - A 1-Year Extension Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Effects on Liver Iron Concentration of Deferasirox and Deferoxamine in Children and Adults With Sickle Cell Disease and Transfusional Hemosiderosis - This study is no longer recruiting patients (Current: 23 Nov 2006)
• Deferasirox - A Study Assessing the Efficacy and Safety of Deferasirox in Patients With Transfusion-Dependent Iron Overload - This study is currently recruiting patients (Current: 23 Nov 2006)
• Deferasirox - An Extension Study of Iron Chelation Therapy With Deferasirox in -Thalassemia Patients With Transfusional Iron Overload - This study is no longer recruiting patients (Current: 23 Nov 2006)
• Deferasirox - Expanded Access of Deferasirox to Patients With Congenital Disorders of Red Blood Cells and Chronic Iron Overload. - This study is currently recruiting patients (Current: 23 Nov 2006)
• Deferasirox - Extension Study of Iron Chelation Therapy With Deferasirox in -Thalassemia and Other Patients With Rare Chronic Anemia and Transfusional Iron Overload - This study is no longer recruiting patients (Current: 23 Nov 2006)
• Deferasirox - Extension Study of Iron Chelation Therapy With Deferasirox in Patients With Transfusional Iron Overload - This study is no longer recruiting patients (Current: 23 Nov 2006)
• Deferasirox - Iron Chelation Therapy With Deferasirox in -Thalassemia Major Pediatric Patients With Transfusional Iron Overload - This study is no longer recruiting patients (Current: 23 Nov 2006)
• Deferasirox - Safety and Efficacy of Deferasirox (ICL670) in Patients With Iron Overload Resulting From Hereditary Hemochromatosis - This study is currently recruiting patients (Current: 23 Nov 2006)
• Deferasirox - Study for the Treatment of Transfusional Iron Overload in Myelodysplastic Patients - This study is currently recruiting patients (Current: 23 Nov 2006)
• Deferasirox - Study of Deferasirox Relative to Subcutaneous Deferoxamine in Sickle Cell Disease Patients - This study is currently recruiting patients (Current: 23 Nov 2006)
• Deferasirox - Study of Deferasirox for Treatment of Transfusional Iron Overload in Myelodysplastic Patients - This study is currently recruiting patients (Current: 23 Nov 2006)
• Deferasirox - Study of Deferasirox in Iron Overload From Beta-Thalassemia Unable to Be Treated With Deferoxamine or Chronic Anemias - This study is no longer recruiting patients (Current: 23 Nov 2006)
• Deferiprone (Ferriprox, L1) - Compassionate Use of Deferiprone - This study is not yet open for patient recruitment (Current: 23 Nov 2006)
• Deferiprone (L1) - Study Using Deferiprone Alone or in Combination With Desferrioxamine in Iron Overloaded Transfusion-Dependent Patients - This study is currently recruiting patients (Current: 23 Nov 2006)
• Deferiprone (L1) - Study With Deferiprone and/or Desferrioxamine in Iron Overloaded Patients - This study is no longer recruiting patients (Current: 23 Nov 2006)
• Deferiprone - Thalassemia (Cooley's Anemia) Clinical Research Network (TCRN) - This study is currently recruiting patients (Current: 23 Nov 2006)
• Deferoxamine - Evaluation of Subcutaneous Desferrioxamine as Treatment for Transfusional Hemochromatosis - This study has been completed (Current: 23 Nov 2006)
• Deferoxamine - Safety & Efficacy of ICL670 Vs. Deferoxamine in Beta-Thalassemia Patients With Iron Overload Due to Blood Transfusions - This study has been completed (Current: 23 Nov 2006)
• Deferoxamine - Safety of ICL670 Vs. Deferoxamine in Sickle Cell Disease Patients With Iron Overload Due to Blood Transfusions - This study is no longer recruiting patients (Current: 23 Nov 2006)
• Deferoxamine - Thalassemia (Cooley's Anemia) Clinical Research Network (TCRN) - This study is currently recruiting patients (Current: 23 Nov 2006)
• Desferal (deferoxamine) - Efficacy Study in Removing Excess Iron From the Heart - This study has been completed (Current: 23 Nov 2006)
• Desferrioxamine - Study Using Deferiprone Alone or in Combination With Desferrioxamine in Iron Overloaded Transfusion-Dependent Patients - This study is currently recruiting patients (Current: 23 Nov 2006)
• Desferrioxamine - Study With Deferiprone and/or Desferrioxamine in Iron Overloaded Patients - This study is no longer recruiting patients (Current: 23 Nov 2006)
• Ferriprox (deferiprone) - Efficacy Study in Removing Excess Iron From the Heart - This study has been completed (Current: 23 Nov 2006)
• Hydroxyurea - Stroke With Transfusions Changing to Hydroxyurea (SWiTCH) - This study is no longer recruiting patients (Current: 23 Nov 2006)
• ICL670 - Safety & Efficacy of ICL670 Vs. Deferoxamine in Beta-Thalassemia Patients With Iron Overload Due to Blood Transfusions - This study has been completed (Current: 23 Nov 2006)
• ICL670 - Safety of ICL670 Vs. Deferoxamine in Sickle Cell Disease Patients With Iron Overload Due to Blood Transfusions - This study is no longer recruiting patients (Current: 23 Nov 2006)
• Pamidronate - Thalassemia (Cooley's Anemia) Clinical Research Network (TCRN) - This study is currently recruiting patients (Current: 23 Nov 2006)
• Ribavirin - Thalassemia (Cooley's Anemia) Clinical Research Network (TCRN) - This study is currently recruiting patients (Current: 23 Nov 2006)

The trial data on this page has been sourced from

• The U.S. National Library of Medicine (NLM) together with ClinicalTrials.gov

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