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Typhoid fever is caused by salmonella typhi and can be a severe infection. A detailed history of the nature of the fever, duration, spikes, aggravating and relieving factors must be asked for. Blood culture remains the main investigative modality. The nature of the fever is similar to that of several other conditions such as brucellosis, malaria, respiratory tract infection, malaria, endocarditis, typhus and liver amoebiasis, hence chances of misdiagnosing typhoid fever are present. However prognosis for recovery is good for most patients.
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