A genetic digestive intolerance to gluten in the diet caused by damage to the intestinal villi with an underlying autoimmune cause. Celiac is believed to be one of the most under-diagnosed and thus misdiagnosed conditions in America. Although the diagnosis rate is about 1 in 5000, the actual estimated prevalence may be as high as 1 in 250. Celiac disease is poorly understood by many American doctors, and may be misdiagnosed as various other digestive disorders such as irritable bowel syndrome (IBS).
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The US based website ClinicalTrials.gov lists information on both federally and privately supported clinical trials using human volunteers.
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Prevention information for Celiac Disease has been compiled from various data sources and may be inaccurate or incomplete. None of these methods guarantee prevention of Celiac Disease.
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Celiac disease is a digestive disease that damages the small intestine and interferes with absorption of nutrients from food. People who have celiac disease cannot tolerate a protein called gluten, which is found in wheat, rye, barley, and possibly oats. When people with celiac disease eat foods containing gluten, their immune system responds by damaging the small intestine. Specifically, tiny fingerlike protrusions, called villi, on the lining of the small intestine are lost. Nutrients from food are absorbed into the bloodstream through these villi. Without villi, a person becomes malnourished--regardless of the quantity of food eaten.
Because the body's own immune system causes the damage, celiac disease is considered an autoimmune disorder. However, it is also classified as a disease of malabsorption because nutrients are not absorbed. Celiac disease is also known as celiac sprue, nontropical sprue, and gluten-sensitive enteropathy. (Source: excerpt from Celiac Disease: NIDDK)
A malabsorption syndrome that is precipitated by the ingestion of GLUTEN-containing foods, such as wheat, rye, and barley. It is characterized by INFLAMMATION of the SMALL INTESTINE, loss of MICROVILLI structure, failed INTESTINAL ABSORPTION, and MALNUTRITION. - (Source - Diseases Database)
A disorder in children and adults; inability to tolerate wheat protein (gluten); symptoms include foul-smelling diarrhea and emaciation; often accompanied by lactose intolerance - (Source - WordNet 2.1)
Ophanet, a consortium of European partners,
currently defines a condition rare when it affects 1 person per 2,000.
They list Celiac Disease as a "rare disease".
Source - Orphanet
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