Articles » Botulism: DBMD

Botulism: DBMD

Article title: Botulism: DBMD

Conditions: Botulism, Wound botulism (type of Botulism food poisoning), Infant botulism

Source: DBMD

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Botulism

 

   

Clinical Features	A neuroparalytic illness characterized by symmetric, descending flaccid paralysis of motor and autonomic nerves, always beginning with the cranial nerves. Symptoms include double vision, blurred vision, drooping eyelids, slurred speech, difficulty swallowing, dry mouth, and muscle weakness. If untreated, illness might progress to cause descending paralysis of respiratory muscles, arms and legs. Botulinum antitoxin (supplied by CDC) can prevent progression of illness and shorten symptoms in severe botulism cases if administered early.
Etiologic Agent	A potent neurotoxin produced from Clostridium botulinum, an anaerobic, spore-forming bacterium.
Incidence	In 1999, 174 cases of botulism were reported to the CDC. Of these, 26 were foodborne, 107 were infant botulism, and 41 were cases of wound botulism.
Sequelae	Death can result from respiratory failure. About 5% die. Recovery takes months. Those who survive may have fatigue and shortness of breath for years.
Transmission	Foodborne botulism follows ingestion of toxin produced in food by C. botulinum. The most frequent source is home-canned foods, prepared in an unsafe manner. Wound botulism occurs when C. botulinum spores germinate within wounds. Intestinal colonization botulism occurs when C. botulinum spores germinate and produce toxin in the gastrointestinal tract.
Risk Groups	All persons. Intestinal colonization botulism usually occurs in infants, and is often called infant botulism. Injection drug users are at increased risk for wound botulism.
Surveillance	In collaboration with state health departments, CDC maintains intensive surveillance for botulism in the United States. Every case of foodborne botulism is treated as a public health emergency because the responsible food, whether homemade or commercial, might still be available for consumption and could make unsuspecting persons ill.
Trends	Other vehicles of transmission include homemade salsa, baked potatoes cooked in aluminum foil, cheese sauce, garlic in oil, and traditionally prepared salted or fermented fish in Alaska. Wound botulism related to the use of black-tar heroin has increased, especially in California.
Challenges	Prompt recognition of clinical syndrome by physicians.
Opportunities	Clinician education. Consumer education about home canning. Educating Alaska natives about proper fermentation techniques. Applying tools of molecular biology.
	December 2001

 
 
 

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