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Causes of Anemia, Iron-Deficiency

Anemia, Iron-Deficiency Causes: Book Excerpts

Related information on causes of Anemia, Iron-Deficiency:

As with all medical conditions, there may be many causal factors. Further relevant information on causes of Anemia, Iron-Deficiency may be found in:

Causes of Anemia, Iron-Deficiency: Online Medical Books

16 MEDICAL BOOKS ONLINE! Review excerpts from medical books online, free, without registration, for more information about the causes of Anemia, Iron-Deficiency.

Iron deficiency anemia: Causes and incidence
(Professional Guide to Diseases (Eighth Edition))

Iron deficiency anemia may result from:

❑ inadequate dietary intake of iron (less than 1 to 2 mg/day), such as in prolonged unsupplemented breast-feeding or bottle-feeding of infants or during periods of stress such as rapid growth in children and adolescents

❑ iron malabsorption, such as in chronic diarrhea, partial or total gastrectomy, chronic diverticulosis, and malabsorption syndromes, such as celiac disease and pernicious anemia

❑ blood loss secondary to drug-induced GI bleeding (from anticoagulants, aspirin, and steroids) or due to heavy menses, hemorrhage from trauma, GI ulcers, esophageal varices, or cancer

❑ pregnancy, which diverts maternal iron to the fetus for erythropoiesis

❑ intravascular hemolysis-induced hemoglobinuria or paroxysmal nocturnal hemoglobinuria

❑ mechanical erythrocyte trauma caused by a prosthetic heart valve or vena cava filters.

A common disease worldwide, iron deficiency anemia affects 10% to 30% of the adult population of the United States. It occurs most commonly in premenopausal women, infants (particularly premature or low-birth-weight neonates), children, and adolescents (especially girls). Persons who are at increased risk for iron deficiency include those of low socioeconomic status who don’t get a well-balanced diet that includes iron-rich foods.

» READ BOOK EXCERPT ONLINE »

Source: Professional Guide to Diseases (Eighth Edition), 2005

Iron deficiency anemia: Causes
(Handbook of Diseases)

Iron deficiency anemia may result from:

❑ inadequate dietary intake of iron (less than 2 mg/day) — for example, during prolonged, unsupplemented periods of breast- or bottle-feeding (not eating solid foods after age 6 months) and during periods of stress, such as rapid growth in children and adolescents

❑ iron malabsorption, as in chronic diarrhea, partial or total gastrectomy, and malabsorption syndromes such as celiac disease

❑ blood loss secondary to drug-induced GI bleeding (from anticoagulants, aspirin, or steroids) or due to heavy menses, hemorrhage from trauma, a GI ulcer, cancer, or bleeding varices

❑ pregnancy, which diverts maternal iron to the fetus for erythropoiesis

❑ intravascular hemolysis-induced hemoglobinuria or paroxysmal nocturnal hemoglobinuria

❑ mechanical erythrocyte trauma caused by a prosthetic heart valve or vena cava filters.

Iron deficiency anemia is most common in premenopausal women, infants (particularly premature and low-birth-weight infants), children, and adolescents (especially girls).

» READ BOOK EXCERPT ONLINE »

Source: Handbook of Diseases, 2003

Iron Deficiency Anemia: Iron Deficiency Anemia - risk factors
(The 5-Minute Pediatric Consult)

  • Low socioeconomic status
  • Certain ethnic groups (such as southeast Asian) may be at increased risk due to dietary practices.

Iron Deficiency Anemia - pathophysiology

  • Iron is required for oxygen transport by hemoglobin.
  • Iron is absorbed primarily in the duodenum.
  • Iron deficiency develops because of an inadequate supply or increased demand for iron, or a combination of these.
  • Sequential stages of iron deficiency:
    • Depletion of iron stores: Reflected by low serum ferritin and absent bone marrow stores (Prussian blue staining)
    • Iron-deficient erythropoiesis: Near-normal number of red blood cells produced, but they have abnormal hemoglobin synthesis with wide distribution in RBC size
    • Iron deficiency anemia: Microcytosis evident

Iron Deficiency Anemia - etiology

  • Causes of inadequate supply include dietary deficiency and malabsorption:
    • Dietary deficiency in infants and young children results from introduction of cow’s milk prior to age 12 months, exclusive breast-feeding beyond age 6 months without iron supplementation, and excessive cow’s milk intake (>24 oz/d).
    • Malabsorption results from surgical resection of intestine, celiac disease
    • Certain foods impair iron absorption (tannins in tea and coffee, phytates).
  • Causes of increased demand include rapid growth and blood loss:
    • Periods of rapid growth include infancy (especially low-birth-weight infants) and adolescence.
    • GI blood loss is most common and includes cow’s milk enteropathy (seen in infants), inflammatory bowel disease (IBD), and bleeding from Meckel diverticulum.
    • Other etiologies of blood loss include perinatal loss, menorrhagia, pulmonary hemosiderosis, and hematuria.

» READ BOOK EXCERPT ONLINE »

Source: The 5-Minute Pediatric Consult, 2008


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