Cure Research for Adrenoleukodystrophy

Cure Research discussion for Adrenoleukodystrophy:

People with ALD accumulate high levels of saturated, very long chain fatty acids in their brain and adrenal cortex because the fatty acids are not broken down by an enzyme in the normal manner. So, when the ALD gene was discovered in 1993, it was a surprise that the corresponding protein was in fact a member of a family of transporter proteins, not an enzyme. It is still a mystery as to how the transporter affects the function the fatty acid enzyme and, for that matter, how high levels of very long chain fatty acids cause the loss of myelin on nerve fibers.

More recently, all the transporters related to ALD protein have been found in the yeast Saccharomyces cerevisiae, and a mouse model for the human disease has been developed. These and other molecular biology approaches should further our understanding of ALD and hasten our progress toward effective therapies (Source: Genes and Disease by the National Center for Biotechnology)

Adrenoleukodystrophy Treatment: Book Excerpts

• Treatment - Paraplegia
• Treatment (Tx) - Adrenal crisis
• Treatment - Adrenal hypofunction
• Treatment - Creutzfeldt-Jakob disease
• Treatment (Tx) - Encephalitis
• Treatment - West Nile encephalitis
• Treatment - Adrenal hypofunction
• Treatment - Creutzfeldt-Jakob disease
• Treatment - Encephalitis
• Treatment - West Nile encephalitis
• Patient counseling - Skin, bronze
• Emergency Actions - Muscle spasticity
• Nursing considerations - Muscle spasticity [Muscle hypertonicity]
• Nursing considerations - Gait, spastic [Hemiplegic gait]

Clinical Trials for Adrenoleukodystrophy

Some of the clinical trials for Adrenoleukodystrophy include:

• Study of Glyceryl Trierucate and Glyceryl Trioleate (Lorenzo's Oil) Therapy in Male Children With Adrenoleukodystrophy - This study is currently recruiting patients (Current: 23 Nov 2006) - glyceryl trierucate,glyceryl trioleate
• Study of Bile Acids in Patients With Peroxisomal Disorders - This study is not yet open for patient recruitment (Current: 23 Nov 2006) - chenodeoxycholic acid,cholic acid,ursodiol
• Randomized Study of Beta Interferon and Thalidomide in Patients With Adrenoleukodystrophy - This study has been completed (Current: 23 Nov 2006) - glyceryl trierucate,glyceryl trioleate,interferon beta,thalidomide
• Study of Pulmonary Complications in Pediatric Patients With Storage Disorders Undergoing Allogeneic Hematopoietic Stem Cell Transplantation - This study is no longer recruiting patients (Current: 23 Nov 2006)
• Study of Oral Cholic Acid in Patients With Inborn Errors of Bile Acid Synthesis - This study has been completed (Current: 23 Nov 2006)
• more trials...»

 » Next page: Statistics about Adrenoleukodystrophy

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