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Diseases » Addison's Disease » Treatments
 

Treatments for Addison's Disease

Treatments for Addison's Disease

The list of treatments mentioned in various sources for Addison's Disease includes the following list. Always seek professional medical advice about any treatment or change in treatment plans.

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Treatment of Addison's disease involves replacing, or substituting, the hormones that the adrenal glands are not making. Cortisol is replaced orally with hydrocortisone tablets, a synthetic glucocorticoid, taken once or twice a day. If aldosterone is also deficient, it is replaced with oral doses of a mineralocorticoid, called fludrocortisone acetate (Florinef)), which is taken once a day. Patients receiving aldosterone replacement therapy are usually advised by a doctor to increase their salt intake. Because patients with secondary adrenal insufficiency normally maintain aldosterone production, they do not require aldosterone replacement therapy. The doses of each of these medications are adjusted to meet the needs of individual patients.

During an addisonian crisis, low blood pressure, low blood sugar, and high levels of potassium can be life threatening. Standard therapy involves intravenous injections of hydrocortisone, saline (salt water), and dextrose (sugar). This treatment usually brings rapid improvement. When the patient can take fluids and medications by mouth, the amount of hydrocortisone is decreased until a maintenance dose is achieved. If aldosterone is deficient, maintenance therapy also includes oral doses of fludrocortisone acetate. (Source: excerpt from Addison's Disease: NIDDK)

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Book Excerpts: Treatment of Addison's Disease

Treatments of Addison's Disease: Online Medical Books

16 MEDICAL BOOKS ONLINE! Review excerpts from medical books online, free, without registration, for more information about the treatments of Addison's Disease.

Adrenal crisis: Treatment (Tx)
(Professional Guide to Diseases (Eighth Edition))

Replacement of corticosteroids, I.V. fluids, potassium, insulin

» READ BOOK EXCERPT ONLINE »

Source: Professional Guide to Diseases (Eighth Edition), 2005

Adrenal hypofunction: Treatment
(Professional Guide to Diseases (Eighth Edition))

For all patients with primary or secondary adrenal hypofunction, corticosteroid replacement, usually with cortisone or hydrocortisone (both of which also have a mineralocorticoid effect), is the primary treatment and must continue throughout life. Adrenal hypofunction may also necessitate treatment with I.V. desoxycorticosterone, a pure mineralocorticoid, or oral fludrocortisone, a synthetic mineralocorticoid; both prevent dangerous dehydration and hypotension.

Adrenal crisis requires prompt I.V. bolus administration of hydrocortisone. Later, doses are given I.M. or are diluted with dextrose in saline solution and given I.V. until the patient’s condition stabilizes.

With proper treatment, adrenal crisis usually subsides quickly; the patient’s blood pressure should stabilize, and water and sodium levels should return to normal. After the crisis, maintenance doses of hydrocortisone preserve physiologic stability.

» READ BOOK EXCERPT ONLINE »

Source: Professional Guide to Diseases (Eighth Edition), 2005

Adrenal hypofunction: Treatment
(Handbook of Diseases)

For all patients with primary or secondary adrenal hypofunction, lifelong corticosteroid replacement, usually with cortisone or hydrocortisone (both of which also have a mineralocorticoid effect) is the primary treatment.

For patients with Addison’s disease, treatment with oral fludrocortisone, a synthetic mineralocorticoid, is necessary to prevent dangerous dehydration, hypotension, and electrolyte disturbances with hyponatremia and hyperkalemia. (See Avoiding adrenal crisis.)

For those with adrenal crisis, prompt I.V. bolus administration of 100 mg of hydrocortisone is key. Later, 50- to 100-mg doses are given I.M. or are diluted with dextrose in saline solution and given I.V. until the patient’s condition stabilizes; up to 300 mg/day of hydrocortisone and 3 to 5 L of I.V. saline solution are required during the acute stage of adrenal crisis.

With proper treatment, adrenal crisis usually subsides quickly; the patient’s blood pressure stabilizes, and water and sodium levels return to normal. After the crisis, maintenance doses of hydrocortisone preserve physiologic stability.

» READ BOOK EXCERPT ONLINE »

Source: Handbook of Diseases, 2003



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